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Effects of neutralizing (pro)renin receptor antibody on the podocytes injury in diabetic nephropathy

Research Project

Project/Area Number 17H07058
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKagawa University (2018)
International University of Health and Welfare (2017)

Principal Investigator

Rahman Md Asadur  香川大学, 医学部, 助教 (30807285)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsPodocyte injury / Diabetic nephropathy / (P)RR antibody / High glucose / Wnt-β-catenin signaling / Wnt-β-catenin
Outline of Final Research Achievements

In vitro studies were conducted to determine the protective effects of (P)RR monoclonal antibodies (mAb) in podocyte injury. The gene expression data revealed that high glucose intervention reduced the mRNA expression of nephrin compared to the osmotic control group, although the level of gene expression was very small. In contrary, (P)RR mAb treatment caused the increase expression of nephrin mRNA, suggestive of the reduced podocyte injury. In case of podocin and synaptopodin the expression level is unsatisfactory. Therefore, we tried to establish the podocyte injury model in the human immortalized podocyte, AB 8/13 cells. Gene expression of podocin, nephrin and synaptopodin in this human podocyte cell line were also not satisfactory. Therefore, the podocin data are in line with our hypothesis that (P)RR mAb has the potential to protect the podocytes against injurious effects.

Academic Significance and Societal Importance of the Research Achievements

The podocin gene expression data suggests the protective effects of(P)RR mAb on high glucose-induced podocyte injury, therefore the study will link a translational approach to clinical benefits.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (4 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin?angiotensin system2019

    • Author(s)
      Rahman Asadur、Hasan Arif Ul、Kobori Hiroyuki
    • Journal Title

      Hypertension Research

      Volume: Epub ahead of print Issue: 6 Pages: 00-00

    • DOI

      10.1038/s41440-019-0223-9

    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases2018

    • Author(s)
      Asadur Rahman, Arif Ul Hasan, Akira Nishiyama and Hiroyuki Kobori
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 2 Pages: 1-21

    • DOI

      10.3390/ijms19020400

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Antiproliferative effects of polyclonal antibody against (pro)renin receptor in pancreatic ductal adenocarcinoma cells2018

    • Author(s)
      Asadur Rahman, Yuki Shibayama, Arif Ul Hasan, Hirofumi Hitomi, Daisuke Nakano, Hiroyuki Kobori, Akira Nishiyama
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neutralization of (pro)renin receptor and inhibition of autophagy on the metastasis of breast carcinoma cells2018

    • Author(s)
      Asadur Rahman, Arif Ul Hasan, Katsuya Miyake, Akira Nishiyama and Hiroyuki Kobori
    • Organizer
      第8回 国際医療福祉大学学会学術大会スケジュール
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-08-25   Modified: 2020-03-30  

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