| Project/Area Number |
17J00868
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
AGGARWAL MAYANK 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC2)
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| Project Period (FY) |
2017-04-26 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2017: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Dopamine / Ventral Tegmental Area / Kamin Blocking / Nucleus Accumbens Shell / Inhibitory inputs / Classical Conditioning / Predicted Reward / Reduciton of Dopamine / Kamin Blocking Effect / Reduction of Dopamine |
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| Outline of Annual Research Achievements |
Rewards induce a transient increase in dopamine neuron firing rate. This reward induced dopamine response is diminished when the reward is predictable. The reduction in the dopamine response evoked by predicted rewards is necessary for the Kamin Blocking Effect (KBE).
KB refers to the blocking of the formation of an association between a cue (blocked cue) and a temporally contiguous reward if, during the conditioning procedure, the cue is presented simultaneously with another cue (blocking cue) which has previously been conditioned using the same reward.
Research conducted in the previous fiscal year found that output of the nucleus accumbens (NAc) and inhibitory inputs to the dopamine neurons during the compound cue conditioning phase played an important role in KBE. This suggested that the output of the accumbens may exert control over the inhibitory input to the dopamine neurons to produce the reduction in dopamine response to the predicted reward. However, such control would need to be learnt during the conditioning of the blocking cue. In this fiscal year, the output of the nucleus accumbens was inhibited during the conditioning of the blocking cue. This manipulation abolished the KBE, supporting the inference drawn from the previously conducted experiments. It was also found that only sign trackers, and not goal trackers, exhibit the KBE.
Ongoing: i) Writing of a thesis towards the completion of my PhD degree; and ii) Writing of papers encompassing the foregoing results.
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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