Analysis of adverse effects of acetylcholinergic pesticides focused on the induction of host defense reaction and immune disruption
| Project/Area Number |
17K00547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Nagoya University |
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Principal Investigator |
Kawabe Tsutomu 名古屋大学, 医学系研究科(保健), 教授 (20378219)
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| Co-Investigator(Kenkyū-buntansha) |
松島 充代子 名古屋大学, 医学系研究科(保健), 講師 (10509665)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 農薬 / ネオニコチノイド系農薬 / マクロファージ / T細胞 / ネオニコチノイド / アセチルコリン作動系農薬 / アセタミプリド / 肺胞マクロファージ / 有機リン系農薬 |
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| Outline of Final Research Achievements |
In this study, we investigated the effects of acetylcholinergic pestcides, particularly neonicotinoid pesticides, on the induction of host defense reaction and functions of macrophages and T cells. We showed that acetamiprid modulated the function of alveolar macrophages. Briefly, acetamiprid inhibited the levels of inflammatory cytokine mRNA expression and phagocytosis induced by imiquimod, a ligand of TLR7, in alveolar macrophages, while acetamiprid exhibited little effect on the induction of host defense reaction including HO-1 expression and autophagy. Moreover, acetamiprid did not affect T-cell activation. These results suggested the possibility that acetamiprid could influence the host defense reaction in the lung.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで神経系への影響が中心に解析されてきたAch作動系農薬が免疫系に与える影響について検討した。免疫応答は賦活化するとアレルギー性疾患や自己免疫疾患を発症させ、抑制されると免疫不全状態として感染症や免疫監視機構の減弱化による悪性腫瘍の発症に繋がる。ACh作動系農薬が及ぼす免疫応答の撹乱作用を明らかにできれば、新たな神経系と免疫系のネットワークを構築でき、また農薬をもとにした治療薬の開発が期待できる。
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Report
(4 results)
Research Products
(47 results)
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[Presentation] Modification of allergic inflammation in murine model of allergic conjunctivitis without CD40 signal.2019
Author(s)
Ko Iwaki, Miyoko Matsushima, Mikiko Kawabe, Masako Mizutani, Yuka Tsubosaki, Masahiro Takekoshi, Kyohka Tanaka, Goki Inoue, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe
Organizer
IUIS2019
Related Report
Int'l Joint Research
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[Presentation] Quercetin-induced cytoprotective action by modification of cell membrane2019
Author(s)
Miyoko Matsushima, Haruka Nose, Yuto Kusatsugu, Kyohka Tanaka, Masahiro Takekoshi, Yuka Tsubosaki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe
Organizer
IUIS2019
Related Report
Int'l Joint Research
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[Presentation] Effects of diazinon on mast cell activation2018
Author(s)
TANAKA Kyohka, MATSUSHIMA Miyoko, ATSUMI Kazuko, SASOU Kanako, SUGIYAMA Tomoshi, OHDACHI Tomoko, UEYAMA Jun, HASHIMOTO Naozumi, KAWABE Tsutomu
Organizer
18th World Congress of Basic and Clinical Pharmacology
Related Report
Int'l Joint Research
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