| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Methyl mercury chloride was orally administered to ICR mice. Administration of half the amount of methylmercury that causes typical toxicity in mice induced oxidative stress, activation of astrocytes, protein expression of aquaporin and edema, specifically in periaqueductal gray matter. The amount of mercury accumulated in this region was similar to that in the cerebral cortex and cerebellum, where the effects of methylmercury toxicity were not observed. These results revealed that the periaqueductal gray matter was particularly vulnerable to methylmercury. We are currently investigating the relationship between sex steroid hormones and sex differences in toxicity to this new toxicity and other neurotoxicity.
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