Construction of Photoreceptor Cell for Understanding Retinal Diseases which can Evaluate Ion Concentration and Energy Homeostasis
| Project/Area Number |
17K01380
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Ritsumeikan University |
|---|
Principal Investigator |
Amano Akira 立命館大学, 生命科学部, 教授 (60252491)
|
|---|
| Project Period (FY) |
2017-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 生体モデリング・フィジオーム / 加齢黄斑変性症 / 網膜細胞数理モデル / 視細胞電気生理モデル / 視細胞モデル / 双極細胞モデル / 光電位変換機構 / 網膜電図 / 双極細胞 / 視細胞 / エネルギー代謝 / 細胞モデル |
|---|
| Outline of Final Research Achievements |
In this research, we have constructed mathematical models of the cells in retina, that converts light signal to the neuron activities. Most of the proposed models of cells in retina are aimed to analyze how the visual perception is realized, however in this research, we have focused on the construction of mathematical models aimed to analyze retinal diseases. Since some of the retinal diseases are related with the lack of energy supply in retinal cells, thus the models were constructed to evalute energy consumption under various light conditions.
|
| Academic Significance and Societal Importance of the Research Achievements |
網膜に関連する細胞モデルは，従来は，どのような仕組みで視覚が実現されているかという科学的な観点からの研究が主であったのに対し，本研究では，網膜に起因する眼疾患の病態，病因，遺伝的変異の解析を目的とする細胞モデルの構築を行った．この結果，網膜におけるエネルギー不足に起因する疾患の評価に必要となる，網膜のエネルギー消費を計算できるモデルを構築することができた．このモデルを用いることで，暗時および光刺激時に網膜で消費されるエネルギーを計算することが可能になり，網膜の保護のために，どのような照明条件が適切かといった臨床に関わる問題を解析することができるようになった．
|
Report
(6 results)
Research Products
(83 results)
-
-
-
-
-
[Journal Article] Evaluation of critical flicker-fusion frequency measurement methods using a touchscreen-based visual temporal discrimination task in the behaving mouse2018
Author(s)
Nomura, Y., Ikuta, S., Yokota, S., Mita, J., Oikawa, M., Matsushima, H., Amano, A., Shimonomura, K., Seya, Y., & Koike, C.
-
Journal Title
Neuroscience Research
Volume: -
Pages: 1-6
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] ヒト多能性幹細胞由来心筋細胞のシミュレーションモデル開発によるペースメーカー機転の多重メカニズム解析2020
Author(s)
糀谷泰彦, 幸田茂也, 姫野友紀子, 牧山武, 山本雄大, ウリヤンハイ イミン, 吉永大介, 柏麻美, 天野晃, 野間昭典, 木村剛
Organizer
第97回日本生理学会大会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Significance of cell-specific precise computer simulation using new mathematical models of human induced pluripotent stem cell derived cardiomyocyte in drug testing.2018
Author(s)
Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Fumika Yokoi, Sayako Hirose, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano.
Organizer
European Society of Cardiology Congress 2018 (ESC2018)
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
