Screening of cancer cell 3D invasion inhibitors from microbial metabolites

• Project/Area Number: 17K01967
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Aichi Medical University
• Principal Investigator: Umezawa Kazuo 愛知医科大学, 医学部, 教授 (70114402)
• Co-Investigator(Kenkyū-buntansha): 小出 直樹 愛知医科大学, 医学部, 教授 (50308962)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: がん細胞 / 三次元培養 / 遊走 / 浸潤 / NF-kappa B / I-kappa B kinase / ketomycin / DHMEQ / 転移 / 放線菌 / スクリーニング / IKK-beta / 生理活性物質 / 微生物 / 阻害剤

Outline of Final Research Achievements

In the present research, we have screened low molecular weight compounds that inhibit cancer cell migration from microbial culture filtrates and our own chemical library, then, we have evaluated their effect on three-dimensional (3D) invasion. As a result, we found NF-kappa B inhibitor DHMEQ, migracinal that is a novel derivative of migracin, terfestatin D that is novel microbial metabolite, and a known antibiotic ketomycin as inhibitors of two-dimensional (2D) migration and invasion. Among them, DHMEQ and ketomycin were found to inhibit 3D invasion of cancer cells, and we looked into the mechanism of inhibition. The mechanistic study has shown that ketomycin is a new inhibitor of I-kappa B kinase.

Academic Significance and Societal Importance of the Research Achievements

学術的意義として、新規化合物p-terphenyl glycosideのterfestatin Dとmigracinalを発見し、ketomycinに新規活性を見出した。一方、DHMEQや浸潤を阻害するconophyllineにおいては疾患に関与する多くの新規活性を見出した。社会的意義として、ほとんどの成果を論文および学会発表して知見を社会に広めた。また、海外の大学と多くの共同研究を行って研究のグローバル化を推進させた。さらに3D浸潤は2D浸潤より臨床上の転移に近いモデルとされ、3D浸潤を阻害するDHMEQとketomycinは毒性の少ない抗がん剤として発展する可能性がある。

Research Products

• [Int'l Joint Research] Poznan University of Medical Sciences(ポーランド)
• [Int'l Joint Research] Shenzhen University/Shenyang Pharmaceutical University(中国)
• [Int'l Joint Research] Queensland University of Technology(オーストラリア)
• [Int'l Joint Research] University of Halle(ドイツ)
• [Int'l Joint Research] University of San Francisco(ブラジル)
• [Int'l Joint Research] Poznan University of Medical Sciences(ポーランド)
• [Int'l Joint Research] Shenzhen University/Shenyang Pharmaceutical University(中国)
• [Int'l Joint Research] University of Bergen(ノルウェー)
• [Int'l Joint Research] Bashkortostan State Medical University(ロシア連邦)
• [Int'l Joint Research] University of Bergen(Norway)
• [Int'l Joint Research] Shenyang Pharmaceutical University/Shenzhen University(China)
• [Int'l Joint Research] University of Freiburg(Germany)
• [Journal Article] Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin (2020)
  • Author(s): K. Umezawa, Y. Lin
  • Journal Title: BBA-Proteins and Proteomics 1868 (2020) 140412 Volume: in press
  • Peer Reviewed
• [Journal Article] Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin (2020)
  • Author(s): L. Wang, M. Li, Y. Lin, S. Du, Z. Liu, J. Ju, H. Suzuki, M. Sawada, K. Umezawa
  • Journal Title: J. Antibiot. Volume: in press Issue: 9 Pages: 622-629
  • DOI: 10.1038/s41429-020-0302-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Direct and indirect anticancer activity of plant-derived alkaloid conophylline (2020)
  • Author(s): K. Umezawa, K. Shirabe
  • Journal Title: Critical Reviews in Oncogenesis Volume: in press Issue: 2 Pages: 67-72
  • DOI: 10.1615/critrevoncog.2020034129
  • Peer Reviewed
• [Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model (2020)
  • Author(s): S. Morita, K. Shinoda, T. Yoshida, M. Shimoda, Y. Kanno, R. Mizuno, H. Kono, H. Asanuma, K. Nakagawa, K. Umezawa, M. Oya
  • Journal Title: BMC Pharmacology and Toxicology Volume: in press
  • DOI: 10.21203/rs.2.21990/v2
  • Peer Reviewed
• [Journal Article] Anti-Inflammatory effect of Dehydroxymethylepoxyquinomicin, a nuclear factor-kappa B inhibitor, on endotoxin-induced uveitis in rats in vivo and in vitro (2019)
  • Author(s): Y. Ando, H. Keino, A. Kudo, A. Hitrakata, A. A. Okada, K. Umezawa
  • Journal Title: Occular Immunology & Inflammation Volume: in press Issue: 2 Pages: 240-248
  • DOI: 10.1080/09273948.2019.1568502
  • Peer Reviewed
• [Journal Article] The JAK/STAT3 and NF-kappa B signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells (2019)
  • Author(s): K. Shiraiwa, M. Mitsutake, Y. Nakazawa, T. Ogi, K. Suzuki, V. Saenko, K. Umezawa, S. Yamashita, K. Tsukamoto
  • Journal Title: Thyroid Volume: in press Issue: 5 Pages: 674-682
  • DOI: 10.1089/thy.2018.0212
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Growth inhibitory effects of dipotassium glycyrrhizinate in glioblastoma cell lines by targeting microRNAs through the NF-κB signaling pathway (2019)
  • Author(s): G. A. Bonafe, J. S. dos Santos, J. V. Ziegler, K. Umezawa, M. L. Ribeiro, T. Rocha, M. M. Ortega
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 13
  • DOI: 10.3389/fncel.2019.00216
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Causes and mechanisms of peritoneal fibrosis and possible application of NF-κB inhibitor for prevention and treatment (2019)
  • Author(s): A. Breborowicz, K. Umezawa
  • Journal Title: Journal of Medical Science Volume: 88 Issue: 2 Pages: 102-108
  • DOI: 10.20883/jms.352
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation (2019)
  • Author(s): H. Fu, M. Alabdullah, J. Grosmann, F. Spieler, R. Abdosh, V. Lutz, K. Kalies, K. Knopp, K. Rieckmann, S. Koch, M. Nutsias, C. Pilowski, J. Dutzmann D. Sedding, S. Huttelmaier, K. Umezawa, K. Werdan, H. Loppnow
  • Journal Title: Cell Death and Disease Volume: 10 Issue: 12 Pages: 880-880
  • DOI: 10.1038/s41419-019-2109-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC (2019)
  • Author(s): S.-L. Ryan, S. Beard, M. P. Barr, K. Umezawa, S. Heavey, P. Godwin, S. G. Gray, D. Cormican, S. P. Finn, K. A. Gately, A. M. Davies, E. W. Thompson, D. J. Richard, K. J. O’Byrne, M. N. Adams, A.-M. Baird
  • Journal Title: Lung Cancer Volume: 135 Pages: 217-227
  • DOI: 10.1016/j.lungcan.2019.07.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion (2019)
  • Author(s): Y. Lin, Y. Chen, T. Ukaji, S. Okada, K. Umezawa
  • Journal Title: J. Antibiot. Volume: 72 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts (2019)
  • Author(s): N. Ishii, K. Araki, T. Yokobori, K. Hagiwara, G. Dolgormaa, T. Yamanaka, T. Handa, M. Tsukagoshi, T. Igarashi, A. Watanabe, N. Kubo, N. Harimoto, A. Masamune, K. Umezawa, H. Kuwano, K. Shirabe
  • Journal Title: Cancer Science Volume: 10 Issue: 1 Pages: 334-434
  • DOI: 10.1111/cas.13874
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum (2019)
  • Author(s): H. He, X. Gao, X. Wang, X. Li, X. Jiang, Z. Xie, K. Ma, J. Ma, K. Umezawa, Y. Zhang
  • Journal Title: International Immunopharmacology Volume: 71 Pages: 43-51
  • DOI: 10.1016/j.intimp.2019.03.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-kappa B inhibition (2018)
  • Author(s): X. Jiang, H. He, Z. Xie, H. Wen, X. Li, Xin Li, J. Ma, K. Umezawa, Y. Zhang
  • Journal Title: Immunopharmacology and Immunotoxicology Volume: in press Issue: 1 Pages: 32-39
  • DOI: 10.1080/08923973.2018.1510962
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model. (2018)
  • Author(s): Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
  • Journal Title: Mol Med Rep Volume: 18 Pages: 5279-5285
  • DOI: 10.3892/mmr.2018.9533
  • Peer Reviewed / Open Access
• [Journal Article] Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice (2018)
  • Author(s): T. Ohashi, Y. Nakade, M. Ibusuki, R Kitano, T. Yamauchi, S. Kimoto, T. Inoue, Y. Kobayashi, N. Ishii, Y. Sumida, K. Ito, H. Nakao, K. Umezawa, M. Yoneda
  • Journal Title: PLOS One Volume: electronic Issue: 1 Pages: e0210068-e0210068
  • DOI: 10.1371/journal.pone.0210068
  • Peer Reviewed / Open Access
• [Journal Article] The plant alkaloid conophylline inhibits matrix formation of fibroblasts (2018)
  • Author(s): T. Tezuka, A. Ota, S. Karnan, K. Matsuura, K. Yokoo, Y. Hosokawa, D. Vigetti, A. Passi, S. Hatano, K. Umezawa, H. Watanabe
  • Journal Title: J. Biol. Chem. Volume: 293 Pages: 20214-20226
  • Peer Reviewed
• [Journal Article] Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegerative disease models (2018)
  • Author(s): K. Umezawa, I. Kojima, S. Simizu, Y. Lin, H. Fukatsu, N. Koide, Y. Nakade and M. Yoneda
  • Journal Title: Human Cell Volume: 31 Pages: 95-101
  • Peer Reviewed
• [Journal Article] Inhibition of late and early phases of cancer metastasis by NF-κB inhibitor DHMEQ derived from microbial bioactive metabolite epoxyquinomicin: A review. (2018)
  • Author(s): Y. Lin, T. Ukaji, N. Koide and K. Umezawa
  • Journal Title: Int. J. Mol. Sci. Volume: - Issue: 3 Pages: 729-729
  • DOI: 10.3390/ijms19030729
  • Peer Reviewed
• [Journal Article] DTCM-glutarimide delays growth and radiosensitizes glioblastoma. (2018)
  • Author(s): G. BM. Roberto, H. H. Paiva, L. E. B. deSouza, J. A. Pezuk, G. M. Vieira, H. F. deOliveira, K. Umezawa, L. G. Tone and M. S. Brassesco
  • Journal Title: Anti-cancer Agents in Medicinal Chemistry Volume: - Issue: 9 Pages: 1323-1329
  • DOI: 10.2174/1871520618666180423105740
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rational design, synthesis and in vitro evaluation of novel exo-methylene butyrolactone salicyloylamide as NF-κB inhibitor. (2017)
  • Author(s): K. Sidthipong, J. Ma, W. L. Yu, Y. F. Wang, S. Kobayashi, S. Kishino , N. Koide, T. Yokochi, K. Kato, S. Okada and K. Umezawa
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 27 Pages: 562-567
  • Peer Reviewed
• [Journal Article] Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. (2017)
  • Author(s): T. Ikezoe, J. Yang, C. Nishioka, K. Umezawa and A. Yokoyama
  • Journal Title: Bone Marrow Transplantation Volume: 52 Pages: 245-251
  • Peer Reviewed
• [Journal Article] Inhibition of MMP-2-mediated cellular invasion by NF-kappa B inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis. (2017)
  • Author(s): T. Ukaji, Y. Lin, S. Okada and K. Umezawa
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 485 Pages: 76-81
  • Peer Reviewed
• [Journal Article] Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis. (2017)
  • Author(s): M. El-Salhy, K. Umezawa, J. G. Hatlebakk and O. H. Gilja
  • Journal Title: Mol. Med. Reports Volume: 15 Pages: 2106-2112
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice. (2017)
  • Author(s): X. Jiang, B. Wei, Y. Lan, C. Dai, Y. Gu, J. Ma, X. Liu, K. Umezawa and Y. Zhang
  • Journal Title: Immunopharmacology and Immunotoxicology Volume: 39:3 Pages: 157-164
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel p-terphenyl glycoside with a rare 2,6-dideoxy- hexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration. (2017)
  • Author(s): L. Wang, M. Li, J. Tang, Y. Y. Lin, K. Sidthipong, N. Sumida, N. Kushida and K. Umezawa
  • Journal Title: J. Antibiot. Volume: 70 Pages: 987-990
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Conophylline inhibits non-alcoholic steatohepatitis in mice. (2017)
  • Author(s): Y. Nakade, K. Sakamoto, T. Yamauchi, Tadahisa Inoue, Y. Kobayashi, T. Yamamoto, N. Ishii, T. Ohashi; Y. Sumida; K. Ito, H. Nakao, Y. Fukuzawa, K. Umezawa and M. Yoneda
  • Journal Title: PLOS One Volume: 12(6)
  • Peer Reviewed
• [Journal Article] The microenvironmental stromal cells abrogate NF-κB inhibitor induced apoptosis in chronic lymphocytic leukemia (2017)
  • Author(s): C-P. Simon-Gabriel, K. Foerster, M. Benkisser-Petersen, D. Bleckmann, N. Thornton, K. Umezawa, S. Decker, C. Dierks, M. Burger, H. Veelken, R. Claus, J. Duyster, K. Zirlik
  • Journal Title: Hematologica Volume: - Issue: 1 Pages: 136-147
  • DOI: 10.3324/haematol.2017.165381
  • Peer Reviewed
• [Journal Article] Molecular design of sugar-free migracin analog migracinal that inhibits ovarian cancer cell migration and invasion. (2017)
  • Author(s): T. Ukaji, N. Koide, Y. Lin, K. Banno, S. Gantsev and K. Umezawa
  • Journal Title: Creative Surgery and Oncology Volume: 7 (4) Pages: 16-20
  • Int'l Joint Research
• [Journal Article] The unfolded protein response mediated by PERK is casually related to the pathogenesis of intervertebral disc degeneration. (2017)
  • Author(s): T. Fujii, N. Fujita, S. Suzuki, K. Watanabe, T. Tsuji, K. Ishii, T. Takaki, K. Umezawa, T. Miyamoto, K. Horiuchi, M. Matsumoto, M. Nakamura
  • Journal Title: Journal of Orthopaedic Research Volume: - Issue: 5 Pages: 1334-1345
  • DOI: 10.1002/jor.23787
  • Peer Reviewed
• [Presentation] クマササ含有成分および誘導体によるLPSに誘導される炎症反応の抑制 (2020)
  • Author(s): 林音知、深津仁見、小嶋しおり、梅澤一夫、小出直樹
  • Organizer: 第93回日本細菌学会
• [Presentation] 深海カビAspergillusが産生するcyclopeninによる炎症誘起因子発現の抑制とハエ学習障害モデルの改善。 (2019)
  • Author(s): 林音知、王立岩、Wu Yanhua、小出直樹、梅澤一夫
  • Organizer: 新規素材探索研究会第18回セミナー
• [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる細胞の遊走・浸潤および炎症性サイトカイン産生の抑制。 (2019)
  • Author(s): Lin Yinzhi、杉浦信夫、小嶋しおり、小出直樹、梅澤一夫
  • Organizer: 第14回日本ケミカルバイオロジー学会
• [Presentation] 新しいI-κB kinase β阻害剤ketomycinによる乳がん細胞の遊走・浸潤およびヒト臍帯静脈内皮細胞管腔形成の抑制。 (2019)
  • Author(s): Lin Yinzhi、小嶋しおり、梅澤一夫
  • Organizer: 第23回がん分子標的治療学会
• [Presentation] クマササ含有成分および誘導体によるLPS作用の阻害。 (2019)
  • Author(s): Lin Yinzhi、深津仁見、小嶋しおり、梅澤一夫、小出直樹
  • Organizer: 第65回トキシンシンポジウム
• [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫の細胞浸潤抑制と抗がん剤感受性の増強。 (2019)
  • Author(s): Lin Yinzhi、小出直樹、梅澤一夫
  • Organizer: 第78回日本癌学会
• [Presentation] Role of peritoneal NF-κB on cancer and inflammation (2019)
  • Author(s): Kazuo Umezawa
  • Organizer: Medical Forum in Shymkent, Kazakhstan
  • Int'l Joint Research / Invited
• [Presentation] Inhibition of titanium dioxide nanoparticle-induced inflammatory reaction by NF-κB inhibitor DHMEQ in human macrophage-like cells (2018)
  • Author(s): Hitomi Fukatsu, Tamami Ukaji, Saeko Tada-Oikawa, Kiyora Izuoka, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide, Akihiko Ikegami, Sahoko Ichihara, Kazuo Umezawa
  • Organizer: 21st International Symposium on Molecular Medicine
  • Int'l Joint Research
• [Presentation] Amelioration of metabolic syndrome and neurodegenerative disease models by plant-derived alkaloid conophylline (2018)
  • Author(s): Kazuo Umezawa
  • Organizer: 21st International Symposium on Molecular Medicine
  • Int'l Joint Research
• [Presentation] がん細胞の遊走を阻害する放線菌由来ketomycinのスクリーニングと乳がんMDA-MB-231細胞における2Dおよび3D浸潤の抑制 (2018)
  • Author(s): Lin Yinzhi、梅澤一夫
  • Organizer: 第22回がん分子標的治療学会
• [Presentation] 新規NF-κB阻害剤SEMBLによる骨肉腫細胞および線維肉腫細胞に対する抗腫瘍効果 (2018)
  • Author(s): 松尾俊宏，梅澤一夫，松井卓哉，佐藤啓二，河南勝久，出家正隆
  • Organizer: 第91回日本整形外科学会学術総会
• [Presentation] PM2.5モデルTiO2ナノ粒子に誘導されるマクロファージのIL-1 beta産生とNF-kappa B阻害剤DHMEQによる抑制 (2018)
  • Author(s): 深津仁見、梅澤一夫、森田奈央子、内記良一、小松孝行、小出直樹
  • Organizer: 新規素材探索研究会第17回セミナー
• [Presentation] 放線菌由来細胞遊走阻害剤ketomycinの単離と乳がん細胞におけるMMP依存性浸潤の抑制 (2018)
  • Author(s): Lin Yinzhi、Wu Yanhua、梅澤一夫
  • Organizer: 第13回日本ケミカルバイオロジー学会
• [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of 2D and 3D invasion of human breast carcinoma cells (2018)
  • Author(s): Yinzhi Lin, Yanhua Wu, Kazuo Umezawa
  • Organizer: 第77回日本癌学会
• [Presentation] Discovery, mechanism of action, and therapeutic activity of NF-kappa B inhibitor DHMEQ (2018)
  • Author(s): Kazuo Umezawa
  • Organizer: Conference “Future of Oncology is Laid Today”（招待講演）（国際学会）
  • Int'l Joint Research / Invited
• [Presentation] NF-κB阻害剤DHMEQによるナノ粒子誘導IL-1β産生の抑制 (2017)
  • Author(s): 深津仁見、宇梶珠、及川佐枝、出岡、市原佐保、小出直樹、梅澤一夫
  • Organizer: 第12回日本ケミカルバイオロジー学会 2017.6.7-9
• [Presentation] migracin脱糖アルデヒド体migracinalによる卵巣がん細胞遊走・浸潤の抑制 (2017)
  • Author(s): 宇梶珠未、林音知、梅澤一夫
  • Organizer: 第21回がん分子標的治療学会
• [Presentation] NF-κB阻害剤DHMEQによるマウス形質細胞腫SP-2/0細胞のMMP-9およびMMP-13が関与する浸潤の抑制と抗がん剤感受性の増強 (2017)
  • Author(s): Sidthipong Kulrawee、宇梶珠未、梅澤一夫
  • Organizer: 第21回がん分子標的治療学会2017.6.14-16
• [Presentation] NF-κB阻害剤DHMEQによるTiO2ナノ粒子に誘導されるマクロファージ炎症反応の抑制 (2017)
  • Author(s): 宇梶珠未、深津仁見、及川佐枝子、出岡淑、市原佐保子、梅澤一夫、小出直樹
  • Organizer: 第64回トキシンシンポジウム （若手奨励講演）
• [Presentation] Isolation of ketomycin from Streptomyces as an inhibitor of breast cancer cell migration and invasion (2017)
  • Author(s): Yinzhi Lin and Kazuo Umezawa
  • Organizer: 第76回日本癌学会
• [Presentation] Molecular design of sugar-free migracin analog migracinal that inhibits cancer cell migration and invasion (2017)
  • Author(s): Tamami Ukaji, Yinzhi Lin, Naoki Koide, and Kazuo Umezawa
  • Organizer: 第76回日本癌学会
• [Presentation] Inhibition of TiO2 nanoparticle-induced inflammatory reaction in macrophages by NF-κB inhibitor DHMEQ (2017)
  • Author(s): Kazuo Umezawa, Hitomi Fukatsu, Tamami Ukaji and Naoki Koide
  • Organizer: 13th Keio-Yonsei Joint Symposium（招待講演）（国際学会）
  • Int'l Joint Research / Invited
• [Remarks] 愛知医科大学ホームページ
• [Remarks] 梅澤ラボチャンネル
• [Remarks] 愛知医科大学ホームページ
• [Remarks] 梅澤ラボ・チャンネル
• [Remarks] 愛知医科大学ホームページ
• [Remarks] 梅澤ラボ・チャンネル
• [Patent(Industrial Property Rights)] 外用組成物の生産方法 (2018)
  • Inventor(s): 梅澤一夫、小出悠紀子
  • Industrial Property Rights Holder: ブルネエズ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Acquisition Date: 2020
• [Patent(Industrial Property Rights)] マクロライド化合物の毒性のない抗炎症剤・抗転移剤としての新規用途 (2017)
  • Inventor(s): 梅澤一夫、林音知
  • Industrial Property Rights Holder: 愛知医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-193428
  • Filing Date: 2017