| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Recently several physical techniques are reported to open lipid bilayers of cellular membranes for biomedical applications. We designed a new molecular motor (1) with Ru(bpy)3 chromophore which rotates by visible light irradiation. We expected that the rotation would be occurred by intramolecular energy transfer from the triplet excited state of Ru(bpy)3 to the motor part.
In the process of the synthesis of 1, we revealed a new pathway for thermal E-Z isomerization in the molecular motors. Stable (E)-9a directly converts to stable (Z)-9c without photoisomerization. The three-step rotation mechanism has the advantage that rotation can be controlled by UV irradiation with a single fixed wavelength.
When (E)-1a was irradiated with 452 nm light, photoisomerization to (Z)-1c was occurred at about 80%. While photoisomerization of (Z)-1c at same conditions was occurred at about 50%. Further studies about the application to open lipid bilayers of cellular membranes is now in progress.
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