| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
When animals encounter a novel object, they carefully approach and assess the risk of the object, which is called risk assessment behavior. The present study using mice revealed that the perifornical area of the anterior hypothalamus (PeFA) is involved in the regulation of risk assessment and burying behaviors toward a novel object. BTBR mice are an inbred mouse strain with autism-like behaviors including increased burying activity as a rodent behavioral marker for repetitive-stereotypic behavior. BTBR mice showed decreased ratio of risk assessment (sniffing) to duration of stay near the object. Furthermore,
the brain structure of the projection target of PeFA neurons was different from that of control animals.
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