Investigating Dystophinopathy-associated Cardiovascuvar Failure

• Project/Area Number: 17K07092
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: The University of Tokyo
• Principal Investigator: Kimura Koichi 東京大学, 医科学研究所, 特任助教 (50596236)
• Co-Investigator(Kenkyū-buntansha): 大門 雅夫 東京大学, 医学部附属病院, 講師 (80343094)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 筋ジストロフィー / 心筋症 / 自律神経 / 自律神経制御 / 脳・神経 / 循環器・高血圧 / 臨床

Outline of Final Research Achievements

This project consists of 2 animal model studies and 1 clinical study. [Dog model experiments] After the presence of tachycardia and autonomic nerve abnormality was confirmed, the treatment effect of heart rate and autonomic nerve suppression was evaluated. Unfortunately, echocardiography and pathological findings did not show expected results. [Rat model experiments] After the presence of tachycardia and cardiac dysfunction was confirmed, the oral medication was administered. However, side effects of decreased appetite and decreased activity appeared before the treatment benefits achieved for their heart failure. [Multicenter clinical study] Although the approval of ethics committee in each facility and the acquisition of patients' consents proceeded smoothly, the clinical study was temporarily suspended due to COVID-19 pandemic.

Academic Significance and Societal Importance of the Research Achievements

本研究は、筋ジストロフィーという難病、またそれにともなう心筋症に対してより有効な治療法を開発するものである。現在、筋ジストロフィー患者にとって心不全が最も主要な死因であるため、動物モデルおよび臨床研究を通して、その治療法の検討を進める意義は非常にに大きい。今回、自律神経の抑制を通した心不全治療法の確立を試みたが、動物実験では十分な治療効果を得られる前に副作用の出現を認めた。また臨床研究は順調に進捗したものの研究年度後半における新型コロナウイルスの流行により一時中断を余儀なくされた。一方で、この研究によって得られた心不全に関する知見は学術的意義の大きいものであり、複数の成果論文として報告した。

Research Products

• [Journal Article] Relationship Between Mitral Leaflet Size and Coaptation and Their Associated Factors in Patients with Normal Left Ventricular Size and Systolic Function (2021)
  • Author(s): Xu Boqing、Daimon Masao、Kawata Takayuki、Nakao Tomoko、Hirokawa Megumi、Sawada Naoko、Kimura Koichi、Yamanaka Yuko、Morita Hiroyuki、Komuro Issei、Yatomi Yutaka
  • Journal Title: International Heart Journal Volume: 62 Issue: 1 Pages: 95-103
  • DOI: 10.1536/ihj.20-148
  • NAID: 130007977828
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2021-01-30
  • Peer Reviewed / Open Access
• [Journal Article] Dental pulp stem cells can improve muscle dysfunction in animal models of Duchenne muscular dystrophy (2021)
  • Author(s): Nitahara-Kasahara Yuko、Kuraoka Mutsuki、Guillermo Posadas Herrera、Hayashita-Kinoh Hiromi、Maruoka Yasunobu、Nakamura-Takahasi Aki、Kimura Koichi、Takeda Shin’ichi、Okada Takashi
  • Journal Title: Stem Cell Research & Therapy Volume: 12 Issue: 1 Pages: 78-78
  • DOI: 10.1186/s13287-020-02099-3
  • Peer Reviewed
• [Journal Article] Impact of insulin resistance on subclinical left ventricular dysfunction in normal weight and overweight/obese japanese subjects in a general community (2021)
  • Author(s): Hirose Kazutoshi、Nakanishi Koki、Daimon Masao、Sawada Naoko、Yoshida Yuriko、Iwama Kentaro、Yamamoto Yuko、Ishiwata Jumpei、Hirokawa Megumi、Koyama Katsuhiro、Nakao Tomoko、Morita Hiroyuki、Di Tullio Marco R.、Homma Shunichi、Komuro Issei
  • Journal Title: Cardiovascular Diabetology Volume: 20 Issue: 1 Pages: 22-22
  • DOI: 10.1186/s12933-020-01201-6
  • Peer Reviewed
• [Journal Article] Relation of Body Mass Index to Adverse Right Ventricular Mechanics (2021)
  • Author(s): Nakanishi Koki、Daimon Masao、Yoshida Yuriko、Ishiwata Jumpei、Sawada Naoko、Hirokawa Megumi、Kaneko Hidehiro、Nakao Tomoko、Mizuno Yoshiko、Morita Hiroyuki、Di Tullio Marco R.、Homma Shunichi、Komuro Issei
  • Journal Title: The American Journal of Cardiology Volume: 144 Pages: 137-142
  • DOI: 10.1016/j.amjcard.2020.12.069
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Surgical treatment for infective endocarditis in the ageing society: a nationwide retrospective study in Japan (2021)
  • Author(s): Kiriyama Hiroyuki、Kaneko Hidehiro、Itoh Hidetaka、Kamon Tatsuya、Morita Kojiro、Jo Taisuke、Fujiu Katsuhito、Daimon Masao、Takeda Norifumi、Morita Hiroyuki、Yasunaga Hideo、Komuro Issei
  • Journal Title: Open Heart Volume: 8 Issue: 1 Pages: e001627-e001627
  • DOI: 10.1136/openhrt-2021-001627
  • Peer Reviewed
• [Journal Article] Risk factors including preoperative echocardiographic parameters for post-induction hypotension in general anesthesia (2021)
  • Author(s): Tarao Kentaroh、Daimon Masao、Son Kyongsuk、Nakanishi Koki、Nakao Tomoko、Suwazono Yasushi、Isono Shiroh
  • Journal Title: Journal of Cardiology Volume: 21 Issue: 3 Pages: 230-236
  • DOI: 10.1016/j.jjcc.2021.03.010
  • Peer Reviewed
• [Journal Article] 核酸治療薬の普及とBecker型筋ジストロフィー心筋症 (2021)
  • Author(s): 木村公一、大門雅夫、森田啓行、瀬口理、瀬川和彦、青木吉嗣
  • Journal Title: 心臓 Volume: 53 Pages: 69-70
• [Journal Article] 遺伝子治療時代の筋ジストロフィー心筋症 (2021)
  • Author(s): 木村公一、大門雅夫、青木吉嗣
  • Journal Title: 医学のあゆみ Volume: 277 Pages: 406-412
• [Journal Article] High Prevalence of Left Ventricular Non-Compaction and Its Effect on Chemotherapy-Related Cardiac Dysfunction in Patients With Hematological Diseases (2020)
  • Author(s): Hirano M, Kimura K, Ishigaki T, Nojima M, Daimon M, Morita H, Takenaka K, Xu B, Sawada N, Hirokawa M, Komuro I, Morisaki T, Yotsuyanagi H, Kawamata T, Yokoyama K, Konuma T, Kato S, Yasui H, Nagamura-Inoue T, Uchimaru K, Takahashi S, Imai Y, Tojo A.
  • Journal Title: Circulation Journal Volume: 84 Issue: 11 Pages: 1957-1964
  • DOI: 10.1253/circj.CJ-20-0344
  • NAID: 130007928999
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-10-23
  • Peer Reviewed / Open Access
• [Journal Article] Frequency of Clinical Monitoring of Serum Concentrations of Digoxin, Potassium, and Creatinine, and Recording of Electrocardiograms in Digoxin-Treated Patients: A Japanese Claims Database Analysis (2020)
  • Author(s): Ooba Nobuhiro、Sente Ayaka、Abe Megumi、Watanabe Fumiyuki、Tsutsumi Daisuke、Nakamura Kiminobu、Nakayama Toshimitsu、Kimura Koichi、Fukuoka Noriyasu
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 43 Issue: 5 Pages: 913-916
  • DOI: 10.1248/bpb.b19-01116
  • NAID: 130007839281
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2020-05-01
  • Peer Reviewed
• [Journal Article] Comparison Between Healthcare-Associated and Community-Acquired Infective Endocarditis at Tertiary Care Hospitals in Japan (2020)
  • Author(s): Kiriyama Hiroyuki、Daimon Masao、Nakanishi Koki、Kaneko Hidehiro、Nakao Tomoko、Morimoto-Ichikawa Ryoko、Miyazaki Sakiko、Morita Hiroyuki、Daida Hiroyuki、Komuro Issei
  • Journal Title: Circulation Journal Volume: 84 Issue: 4 Pages: 670-676
  • DOI: 10.1253/circj.CJ-19-0887
  • NAID: 130007815600
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-03-25
  • Peer Reviewed / Open Access
• [Journal Article] Age-Dependent Echocardiographic and Pathologic Findings in a Rat Model with Duchenne Muscular Dystrophy Generated by CRISPR/Cas9 Genome Editing (2020)
  • Author(s): Sugihara Hidetoshi、Kimura Koichi、Yamanouchi Keitaro、Teramoto Naomi、Okano Tomoko、Daimon Masao、Morita Hiroyuki、Takenaka Katsu、Shiga Takanori、Tanihata Jun、Aoki Yoshitsugu、Inoue-Nagamura Tokiko、Yotsuyanagi Hiroshi、Komuro Issei
  • Journal Title: International Heart Journal Volume: 61 Issue: 6 Pages: 1279-1284
  • DOI: 10.1536/ihj.20-372
  • NAID: 130007945853
  • Peer Reviewed / Open Access
• [Journal Article] Are there gender differences in the association between body mass index and left ventricular diastolic function? A clinical observational study in the Japanese general population (2020)
  • Author(s): Hirokawa Megumi、Daimon Masao、Kozuma Kayoko、Shinozaki Tomohiro、Kimura Koichi、Nakao Tomoko、Nakanishi Koki、Sawada Naoko、Ishiwata Jumpei、Yoshida Yuriko、Kato Tomoko S、Mizuno Yoshiko、Morita Hiroyuki、Yatomi Yutaka、Komuro Issei
  • Journal Title: Echocardiography Volume: 37 Issue: 11 Pages: 1749-1756
  • DOI: 10.1111/echo.14866
  • Peer Reviewed
• [Journal Article] Left Ventricular End-Diastolic Diameter and Cardiac Mortality in Duchenne Muscular Dystrophy (2020)
  • Author(s): Segawa Kazuhiko、Sugawara Norio、Maruo Kazushi、Kimura Koichi、Komaki Hirofumi、Takahashi Yuji、Sasaki Masayuki
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 16 Pages: 171-178
  • DOI: 10.2147/ndt.s235166
  • NAID: 120007132750
  • Peer Reviewed
• [Journal Article] Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy (2020)
  • Author(s): Teramoto Naomi、Sugihara Hidetoshi、Yamanouchi Keitaro、Nakamura Katsuyuki、Kimura Koichi、Okano Tomoko、Shiga Takanori、Shirakawa Taku、Matsuo Masafumi、Nagata Tetsuya、Daimon Masao、Matsuwaki Takashi、Nishihara Masugi
  • Journal Title: Disease Models & Mechanisms Volume: 13 Issue: 9 Pages: 044701-044701
  • DOI: 10.1242/dmm.044701
  • Peer Reviewed / Open Access
• [Journal Article] Association of arterial stiffness with left atrial structure and phasic function: a community-based cohort study (2020)
  • Author(s): Yoshida Yuriko、Nakanishi Koki、Daimon Masao、Ishiwata Jumpei、Sawada Naoko、Hirokawa Megumi、Kaneko Hidehiro、Nakao Tomoko、Mizuno Yoshiko、Morita Hiroyuki、Di Tullio Marco R.、Homma Shunichi、Komuro Issei
  • Journal Title: Journal of Hypertension Volume: 38 Issue: 6 Pages: 1140-1148
  • DOI: 10.1097/hjh.0000000000002367
  • NAID: 40022090409
  • Peer Reviewed
• [Journal Article] Serum uric acid level and subclinical left ventricular dysfunction: a community-based cohort study. (2020)
  • Author(s): Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
  • Journal Title: ESC Heart Fail. Volume: - Issue: 3 Pages: 1031-1038
  • DOI: 10.1002/ehf2.12691
  • Peer Reviewed / Open Access
• [Journal Article] Carotid intima-media thickness and subclinical left heart dysfunction in the general population (2020)
  • Author(s): Nakanishi Koki、Daimon Masao、Yoshida Yuriko、Ishiwata Jumpei、Sawada Naoko、Hirokawa Megumi、Kaneko Hidehiro、Nakao Tomoko、Mizuno Yoshiko、Morita Hiroyuki、Di Tullio Marco R.、Homma Shunichi、Komuro Issei
  • Journal Title: Atherosclerosis Volume: 305 Pages: 42-49
  • DOI: 10.1016/j.atherosclerosis.2020.05.019
  • Peer Reviewed
• [Journal Article] Sex-specific difference in the association between arterial stiffness and subclinical left ventricular dysfunction (2020)
  • Author(s): Yoshida Yuriko、Nakanishi Koki、Daimon Masao、Ishiwata Jumpei、Sawada Naoko、Hirokawa Megumi、Kaneko Hidehiro、Nakao Tomoko、Mizuno Yoshiko、Morita Hiroyuki、Di Tullio Marco R、Homma Shunichi、Komuro Issei
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: 28 Issue: 7 Pages: 817-823
  • DOI: 10.1093/ehjci/jeaa156
  • Peer Reviewed
• [Journal Article] Subclinical Hypothyroidism as an Independent Determinant of Left Atrial Dysfunction in the General Population (2020)
  • Author(s): Nakanishi Koki、Daimon Masao、Yoshida Yuriko、Sawada Naoko、Hirose Kazutoshi、Iwama Kentaro、Yamamoto Yuko、Ishiwata Jumpei、Hirokawa Megumi、Kaneko Hidehiro、Nakao Tomoko、Mizuno Yoshiko、Morita Hiroyuki、Di Tullio Marco R、Homma Shunichi、Komuro Issei
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 106 Issue: 4 Pages: 1859-1867
  • DOI: 10.1210/clinem/dgaa730
  • Peer Reviewed
• [Journal Article] Influence of visceral adiposity accumulation on adverse left and right ventricular mechanics in the community. (2019)
  • Author(s): Sawada N, Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Hirokawa M, Nakao T, Morita H, Di Tullio MR, Homma S, Komuro I.
  • Journal Title: Eur J Prev Cardiol. Volume: - Issue: 18 Pages: 2006-2015
  • DOI: 10.1177/2047487319891286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 筋ジストロフィー心筋症－遺伝子治療時代の心不全管理 (2021)
  • Author(s): 木村公一、大門雅夫、森田啓行、松村剛、岡田尚巳、青木吉嗣
  • Organizer: 第7回日本心筋症研究会 シンポジウム
  • Invited
• [Presentation] Links Between Arterial Stiffness and Bone Mineral Density in Japanese General Population (2021)
  • Author(s): Yoshiko Mizuno, Koki Nakanishi, Masao Daimon, Issei Komuro
  • Organizer: 第85回日本循環器病学会学術集会
• [Presentation] The impact of tricuspid annular dilation on the severity of tricuspid regurgitation in patients with persistent atrial fibrillation (2021)
  • Author(s): Yuko Yamamoto, Masao Daimon, Tomoko Nakao, Kouki Nakanishi, Megumi Hirokawa, Jumpei Ishiwata, Yuriko Yoshida, Kentaro Iwama, Kazutoshi Hirose, Yasuhiro Mukai, Issei komuro
  • Organizer: 第85回日本循環器病学会学術集会
• [Presentation] Automatic diagnostic algorithm for cardiac sarcoidosis from echocardiographic video by deep learning (2021)
  • Author(s): Susumu Katsushika, Satoshi Kodera, Nobutaka Kakuda, Hiroki Shinohara, Ryo Matsuoka, Hirotaka Ieki, Yasutomi Higashikuni, Masae Uehara, Katsuhito Fujiu, Masao Daimon, Hiroshi Akazawa, Issei Komuro
  • Organizer: 第85回日本循環器病学会学術集会
• [Presentation] 血液疾患患者における左室緻密化障害の合併が化学療法後の心毒性に与える影響 (2020)
  • Author(s): 木村公一、大門雅夫、森田啓行、赤澤宏、中尾倫子、中西弘毅、廣川愛美、澤田直子、石渡惇平、桐山皓行、吉田由理子、廣瀬和俊、岩間健太郎、山本裕子、小室一成
  • Organizer: 第255回日本循環器学会関東甲信越地方会（Clinical Research Award 最優秀賞受賞)
• [Presentation] Comparison between healthcare-associated and community-acquired infective endocarditis at tertiary care hospitals in Japan (2020)
  • Author(s): Masao Daimon, Hiroyuki Kiriyama, Koki Nakanishi, Hidehiro Kaneko, Tomoko Nakao, Ryoko Ichikawa-Morimoto, Sakiko Miyazaki, Hiroyuki Daida, Hiroyuki Morita, Issei Komuro
  • Organizer: 第84回日本循環器病学会学術集会
• [Presentation] Prognostic value of the combined evaluation of right ventricular function by conventional and 2D speckle-tracking echocardiography in patients with non-ischemic dilated cardiomyopathy (2020)
  • Author(s): Jumpei Ishiwata, Masao Daimon, Koki Nakanishi, Tadafumi Sugimoto, Takayuki Kawata, Tomoko Nakao, Megumi Hirokawa, Naoko Sawada, Yuriko Yoshida, Eisuke Amiya, Masaru Hatano, Hiroyuki Morita, Issei Komuro
  • Organizer: 第84回日本循環器病学会学術集会
• [Presentation] Accumulation of visceral adiposity and adverse ventricular mechanics in the community (2020)
  • Author(s): Naoko Sawada, Koki Nakanishi, Masao Daimon, Yuriko Yoshida, Jumpei Ishiwata, Megumi Hirokawa, Tomoko Nakao, Hiroyuki Morita, Issei Komuro
  • Organizer: 第84回日本循環器病学会学術集会
• [Presentation] Arterial Stiffness and Subclinical Left Ventricular Dysfunction in the General Population (2020)
  • Author(s): Yuriko Yoshida, Kouki Nakanishi, Masao Daimon, Tomoko Nakao, Kentaro Iwama, Kazutoshi Hirose, Yuko Yamamoto, Jumpei Ishiwata, Naoko Sawada, Megumi Hirokawa, Hidehiro Kaneko, Yoshiko Mizuno, Hiroyuki Morita, Issei Komuro
  • Organizer: 第84回日本循環器病学会学術集会
• [Presentation] Two-dimensional Speckle Tracking Echocardiography for Diagnosing Chest Pain in the Emergency Room: The Multicenter Prospective Study by A TRAC-SI Group (2020)
  • Author(s): Katsuhisa Ishii, Yusuke Yoshikawa, Eiichi Hyodo, Yoshihiro Seo, Hajime Kihara, Hiroyuki, Watanabe, Masao Daimon, Atsushi Tanaka, Takashi Akasaka, Hiroshi Ito
  • Organizer: 第84回日本循環器病学会学術集会
• [Presentation] 世界各国と比較した健常成人日本人の心エコー図における左室サイズと機能：The WASE studyからの解析結果 (2020)
  • Author(s): 三好達也、大門雅夫、竹内正明
  • Organizer: 第31回日本心エコー図学会学術集会
• [Presentation] 頸動脈内膜中膜複合体厚と潜在性左心機能低下に関する検討 (2020)
  • Author(s): 中西弘毅、大門雅夫、吉田由理子、石渡惇平、澤田直子、廣川愛美、金子英弘、中尾倫子、水野由子、森田啓行、小室一成
  • Organizer: 第31回日本心エコー図学会学術集会
• [Presentation] 生体肺移植ドナー術後に心膜切開後症候群による心膜炎を認めた一例 (2020)
  • Author(s): 井上翔太、大門雅夫、中尾倫子、鈴木博英、佐々木賀津乃、千明真弓、宮崎令子、須藤芳実、中村和奏、矢冨裕
  • Organizer: 第31回日本心エコー図学会学術集会
• [Presentation] ラミンA/C遺伝子変異5症例の心エコー図所見の検討 (2020)
  • Author(s): 山本裕子、大門雅夫、中尾倫子、中西弘毅、廣川愛美、澤田直子、石渡惇平、桐山皓行、吉田由理子、岩間健太郎、廣瀬和俊、小室一成
  • Organizer: 第31回日本心エコー図学会学術集会
• [Presentation] レニン依存性高血圧を呈したNutcracker症候群の１症例 (2020)
  • Author(s): 菅原将代 大門雅夫 千明真弓 井上翔太 久保田ともよ 鈴木博英 中尾倫子 小野佳一 矢冨裕
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] 当院におけるLibman-Sacks心内膜炎9症例の心エコー図所見および臨床像の検討 (2020)
  • Author(s): 井上翔太 大門雅夫 中尾倫子 鈴木博英 菅原将代 千明真弓 久保田ともよ 小野佳一 矢冨裕
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] アスピリン投与中の虚血性心疾患患者における血小板凝集能に対する年齢の影響 (2020)
  • Author(s): 中尾倫子、大門雅夫、井上翔太、菅原将代、鈴木博英、西川真子、矢冨裕
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] 動脈スティフネスの亢進が潜在性左室機能障害に及ぼす影響とその性差の検討 (2020)
  • Author(s): 吉田 由理子, 中西 弘毅, 大門 雅夫, 金子 英弘, 中尾 倫子, 水野 由子, 森田 啓行, 小室 一成
  • Organizer: 日本超音波医学会第93回学術集会
• [Presentation] Optimal Indication and Timing of Surgical Treatment of TR: From Cardiologists' Viewpoint (2020)
  • Author(s): 大門雅夫
  • Organizer: 第84回日本循環器病学会学術集会
  • Invited
• [Presentation] TRの手術適応決定に重要な心エコー図所見 (2020)
  • Author(s): 大門雅夫
  • Organizer: 第31回日本心エコー図学会学術集会 シンポジウム
  • Invited
• [Presentation] 日循弁膜症ガイドライン：三尖弁逆流に関する改訂ポイント (2020)
  • Author(s): 大門雅夫
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] Carotid intima-media thickness and subclinical left heart dysfunction in the general population (2020)
  • Author(s): Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio M, Homma S, Komuro I
  • Organizer: European Society of Cardiology Congress 2020
  • Int'l Joint Research
• [Presentation] Sex-specific difference in the association between arterial stiffness and subclinical left ventricular dysfunction (2020)
  • Author(s): Yoshida Y, Nakanishi K, Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y , Morita H, Di Tullio M, Homma S, Komuro I
  • Organizer: European Society of Cardiology Congress 2020
  • Int'l Joint Research
• [Presentation] Diagnostic accuracy of left ventricular diastolic transverse strain imaging by speckle tracking echocardiography for diagnosing chest pain in diabetic patients (2020)
  • Author(s): Ishii K, Yoshikawa Y, Hyodo E, Seo Y, Ishizu T, Kihara H, Daimon M, Tanaka A, Watanabe H, Akasaka T, Ito H, J Yoshikawa J
  • Organizer: European Society of Cardiology Congress 2020
  • Int'l Joint Research
• [Presentation] Association between surgical treatment and in-hospital mortality in patients with infective endocarditis stratified by NYHA classification: a nationwide retrospective study in Japan (2020)
  • Author(s): Kiriyama H, Kaneko H, Kamon T, Itoh H, Jo T, Fujiu K , Daimon, Morita H, Yasunaga H, Komuro I
  • Organizer: European Society of Cardiology Congress 2020
  • Int'l Joint Research
• [Presentation] Visceral fat accumulation and left atrial phasic function in the general population (2020)
  • Author(s): Sawada N, Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Hirokawa M, Koyama K, Nakao T, Mizuno Y, Morita H, Di Tullio M, Homma S, Komuro I
  • Organizer: European Society of Cardiology Congress 2020
  • Int'l Joint Research
• [Presentation] Prognostic Impact of Cardio-Renal Failure in Patients with Duchenne/Becker Muscular Dystrophy: A Prospective Multicenter Cohort Study (2018)
  • Author(s): Koichi Kimura, Masao Daimon, Hiroyuki Morita, Masaru Horio, Takayuki Kawata, Tomoko Nakao, Megumi Hirokawa, Naoko Sawada, NHO Investigators, Katsu Takenaka, and Issei Komuro
  • Organizer: AHA Scientific Sessions 2018
  • Int'l Joint Research
• [Book] 心エコー 二次性心筋症へのトータルアプローチ (2018)
  • Author(s): 木村公一 他
  • Total Pages: 218
  • Publisher: 文光堂
• [Remarks]
  • URL: https://www.u-tokyo.ac.jp/focus/ja/people/k0001_01619.html