| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
A nucleolar stress response mechanism in which abnormal nucleolar function increases the tumor suppressor p53 and suppresses cell proliferation has been identified. In present study, we found that 1) the nucleolar stress response may be a novel mitotic surveillance mechanism that suppresses cell proliferation by mitotic abnormalities, 2) we identified novel compounds that induce the nucleolar stress response and kill tumor cells by increasing P53, and 3) regulators of the nucleolar stress response are involved in the sensitivity of gastric cancer to 5FU treatment.
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