| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Recent studies suggest that RNA-binding regulates localization and functions of various chromatin proteins. Here we investigated physical and functional interaction of RNA and MPP8, which is a component of the transcriptional repressor complex called HUSH complex. We found that MPP8 possesses the RNA-binding activity and it interacts with transcripts from a subset of ZNF genes. Furthermore, there was a relatively strong correlation between MPP8-ZNF transcript interaction and nuclear retention of the transcripts. These results indicate that MPP8 or HUSH complex may post-transcriptionally regulate a subset of ZNF genes, implying a novel function of MPP8.
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