Structure-function analysis of a vacuolar membrane factor that controls selective autophagy
| Project/Area Number |
17K07319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
Fujioka Yuko 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 (80399964)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | オートファジー / 蛋白質 |
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| Outline of Final Research Achievements |
In this study, we studied the structure and function of Vac8, a component of the PAS that mediates autophagy initiation. Our results show that the PAS is a complex with liquid-like properties (droplets) and that Vac8 acts as a link between the PAS and the vacuolar membrane via Atg13. Additionally, we suggested that the roles of Vac8 and Atg13 in PAS tethering to the vacuole are common between starvation-induced autophagy and the Cvt pathway although the components of the starvation PAS and the selective PAS functioning in the Cvt pathway were known to be different.
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| Academic Significance and Societal Importance of the Research Achievements |
オートファジーがどのように引き起こされるのかを理解することは、それ自体が科学の発展に寄与するだけでなく、オートファジーの機能不全が関与する、神経変性疾患をはじめとする各種疾患の治療法、治療薬の開発をする上で重要な基盤となる。本研究成果によって、オートファジーの始動機構の一端を明らかにすることができたが、今後も引き続き研究を進めていく予定である。
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Report
(4 results)
Research Products
(9 results)
