| Project/Area Number |
17K07392
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Chuo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 減数分裂 / 細胞周期 / 遺伝的組換え / チェックポイント / DNA複製 / 第一減数分裂 / 分裂酵母 / 転写因子 / 遺伝子組換え / 体細胞分裂 / 遺伝子発現 / 生物 / 発現制御 |
|---|
| Outline of Final Research Achievements |
Meiosis generates genetic diversity and is essential for gametogenesis, but there are many unclear points about its regulatory mechanism. In this study, we showed that Cds1 kinase phosphorylates the forkhead transcription factor Mei4 and that phosphorylation is required for checkpoints in the regulation of premeiotic DNA replication and initiation of recombination. Regarding the control mechanism of pre-meiotic DNA replication and first meiotic initiation, we showed that Cds1 phosphorylates Fkh2, a forkhead transcription factor, and that this phosphorylation is required for the checkpoint.
|
| Academic Significance and Societal Importance of the Research Achievements |
減数分裂は遺伝的多様性を生み出し、配偶子形成に必須であるがその制御機構に関しては不明な点が多い。減数分裂において、細胞周期が順序正しく進行するために、チェックポイント機構が必要である。しかし、このチェックポイント機構は、ほとんどの生物で未解明であった。この研究により、その一部が明らかにされた。
|
Report
(5 results)
Research Products
(11 results)
