| Project/Area Number |
17K08081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
Taniguchi Takako 宮崎大学, 産業動物防疫リサーチセンター, 助教 (50500097)
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| Co-Investigator(Kenkyū-buntansha) |
三澤 尚明 宮崎大学, 産業動物防疫リサーチセンター, 教授 (20229678)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Helicobacter cinaedi / Ⅵ型分泌装置 / TssG遺伝子 / 動物感染実験 / 抗生物質 / 薬剤感受性試験 / マウス腸管定着モデル / 抗菌薬 / 再燃 / T6SS / ヒト腸管上皮細胞 / 付着・侵入能 |
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| Outline of Final Research Achievements |
Helicobacter cinaedi causes bacteremia and inflammation of subcutaneous tissue in humans. To clarify the role of the type VI secretion system (T6SS) in H. cinaedi, the pathogenicity of a mutant strain harboring a deletion in a T6SS-related gene, TssG, was compared for pathogenicity with that of a wild-type strain. In addition, mice infected with H. cinaedi were administered some antimicrobials orally to establish a useful treatment method. Although the suggested that suggested that combined administration of ABPC and MINO or administration of IPM/CS alone would be effective for eliminating H. cinaedi, further studies to establish an ideal administration method will be required.
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| Academic Significance and Societal Importance of the Research Achievements |
H. cinaediによるヒト菌血症や軟部組織の炎症などは、抗菌薬の投与により寛解するが、30～60％の患者で再燃するという報告もあり、有効な治療法は確立していない。病原因子の分泌装置としての機構であるⅥ型分泌装置（T6SS）の関連遺伝子(TssG)は、病原性への関与が低いことが示唆されたが、H. cinaedi感染マウスを用いた抗生物質投与試験において、今後の有効な治療法に繋がる新な知見が得られた。
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