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Evaluation of canine newly developed obsesity treatment using fecal microbiome analysis

Research Project

Project/Area Number 17K08111
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

Mori Akihiro  日本獣医生命科学大学, 獣医学部, 准教授 (60549559)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糞便 / マイクロバイオーム / 犬 / プロバイオティクス / プレバイオティクス / ドッグフード / マイクロバイオ-ム / 肥満
Outline of Final Research Achievements

The impact of four commercially available prescription diet regimens on the fecal microbiome in healthy dogs were evaluated. The diet regimens used were as follows: weight-loss diet, low-fat diet, renal diet, and anallergenic diet. In the results, commercial prescription diet influences the fecal microbiome in healthy dogs. Next, this study investigated the effect of a commercially available digestive enzyme and probiotic preparation on fecal microbiomes of 11 healthy, client-owned, pet dogs. We have found that a digestive enzyme and probiotic preparation can influence the fecal microbiomes of healthy, client-owned, pet dogs.

Academic Significance and Societal Importance of the Research Achievements

本研究では様々な市販の療法食が健康な犬の腸内細菌叢に与える影響について調査した。療法食には様々な組成のものがあり、それぞれの療法食が特徴的な腸内細菌叢に変化させることがわかった。これは、食事やプロバイオティクスおよびプレバイオティクスを給与することにより、犬の腸内細菌叢をコントロールできる可能性を示した。消化器疾患やアレルギー疾患などの犬に多いとされる疾患を腸内細菌叢に着目することにより、未然に予防ができるかもしれないということを示した、最初の研究になると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Comparison of the effects of four commercially available prescription diet regimens on the fecal microbiome in healthy dogs2019

    • Author(s)
      MORI Akihiro、GOTO Ai、KIBE Ryoko、ODA Hitomi、KATAOKA Yasushi、SAKO Toshinori
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 12 Pages: 1783-1790

    • DOI

      10.1292/jvms.19-0055

    • NAID

      130007775519

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary size alteration and adverse effects of radiation therapy performed in 9 dogs with pituitary-dependent hypercortisolism2018

    • Author(s)
      Sawada Harumi、Mori Akihiro、Lee Peter、Sugihara Shiho、Oda Hitomi、Sako Toshinori
    • Journal Title

      Research in Veterinary Science

      Volume: 118 Pages: 19-26

    • DOI

      10.1016/j.rvsc.2018.01.001

    • Related Report
      2018 Research-status Report
  • [Journal Article] Time-action profiles of insulin degludec in healthy dogs and its effects on glycemic control in diabetic dogs2018

    • Author(s)
      ODA Hitomi、MORI Akihiro、ISHII Satoko、SHONO Saori、ONOZAWA Eri、SAKO Toshinori
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 11 Pages: 1720-1723

    • DOI

      10.1292/jvms.17-0714

    • NAID

      130007521208

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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