| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Almost of all insects exemplify the theory of “trade-off” between longevity and reproduction. Among these, Japanese one of the eusocial insects, R. speratus break through that theory and have extraordinary long lifespan with high reproductivity. We hypothesised that long-lived termites have strong oxidative defence mechanisms and investigated. As a result, we found that R. speratus have an excellent antioxidative system. Especially, termite reproductives showed high expression of the antioxidant enzymes as well as injury repair enzymes. These indicates that an efficient antioxidant system positively functions to their longevity.
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| Academic Significance and Societal Importance of the Research Achievements |
長寿を可能にしたシロアリの戦略はヒトとは一見異なるように見える。しかし, 本研究からヒトの老化抑制・健康寿命延長にも応用可能な知見が得られたと我々は考えている。今まで老化・寿命の生物モデルとして扱われてこなかった生物を, 真に長寿命な生物として研究対象として取り扱うことが可能であることを示したことで, 今後のこの分野のブレークスルーが期待できる。
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