• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Efficiency production of functional lignin degradation product by mimic of degradation mechanism in nature

Research Project

Project/Area Number 17K08166
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental agriculture(including landscape science)
Research InstitutionNiigata University

Principal Investigator

Mikame Keigo  新潟大学, 自然科学系, 准教授 (70571701)

Co-Investigator(Kenkyū-buntansha) 佐藤 伸  青森県立保健大学, 健康科学部, 教授 (40310099)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsリグニン / 酸化分解 / 木材腐朽菌 / 生理活性 / UV吸収 / キノコ廃菌床 / アルドール縮合 / アリドール縮合 / バイオマス / 廃棄物再資源化
Outline of Final Research Achievements

In this study, we study efficiency production of functional lignin degradation products with high added value by mimic of degradation mechanism in nature. The yields of lignin oligomers having long-wavelength UV absorption from white rot fungi treated bamboo greatly increased with alkaline cupric (II) oxidation compared to untreated birch wood. As physiologically activities evaluation of lignin oligomers having long-wavelength UV absorption, administration test of these lignin oligomers to mouse fed a high-fat diet and animal cell culture were conducted. As a result of test, relieving effect of kidney damage and oxidative stress.

Academic Significance and Societal Importance of the Research Achievements

自然界のリグニン分解をmimicした木材腐朽菌前処理後のアルカリ酸化銅分解を行うことにより、生理活性を有する長波長UV吸収リグニン分解物の高効率生成手法を構築した。
リグニンの高付加価値利用は、木質多糖類からの糖化・発酵やリグニンからのフェノール誘導体生産など、技術としては確立されているが、コスト面で進展していないリグノセルロースの利活用も可能となる。これにより炭水化物から石油代替脂肪族化学原料生産、リグニンから芳香族化学原料生産への流れを作ることも可能である。これらの流れは森林資源の新たな利用分野を作り、荒廃が進む日本の森林を蘇らせることにつながることが期待でき、地球温暖化対策へ寄与できる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (13 results)

  • [Journal Article] Facilitation of aldol condensation for lignin alkaline cupric (II) oxidation products having long-wavelength UV absorption2021

    • Author(s)
      Tsuchida Teppei、Watanabe Takashi、Mikame Keigo
    • Journal Title

      Transactions of the Materials Research Society of Japan

      Volume: 46 Issue: 1 Pages: 25-28

    • DOI

      10.14723/tmrsj.46.25

    • NAID

      130007993806

    • ISSN
      1382-3469, 2188-1650
    • Year and Date
      2021-03-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lignin-derived low-molecular-weight oxidized lignophenol stimulates AMP-activated protein kinase and suppresses renal inflammation and interstitial fibrosis in high fat diet-fed mice2020

    • Author(s)
      Sato Shin、Norikura Toshio、Mukai Yuuka、Yamaoka Shin、Mikame Keigo
    • Journal Title

      Chemico-Biological Interactions

      Volume: 318 Pages: 108977-108977

    • DOI

      10.1016/j.cbi.2020.108977

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ソルボリシス反応におけるリグニン分解挙動に及ぼす反応条件と酸触媒の影響2020

    • Author(s)
      橋詰みずき, 小松博幸, 三亀啓吾, 多島 秀男, 山際和明
    • Organizer
      第22回化学工学会学生発表会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高脂肪食を摂取したマウスの腎障害に及ぼす天然リグニン由来低分子リグノフェノールの影響2020

    • Author(s)
      杉澤春奈, 乗鞍敏夫, 三亀啓吾, 山口満里奈, 鹿野綾乃, 高橋なごみ, 山岡伸, 向井友花, 佐藤伸
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Efficiently production of lignin alkaline cupric (Ⅱ) oxidative degradation products with long-wavelength UV absorption capacity by acceleration of aldol condensation reaction2020

    • Author(s)
      T. TSUCHIDA, T.WATANABE K. MIKAME
    • Organizer
      30th Annual Meeting of MRS-J
    • Related Report
      2020 Annual Research Report
  • [Presentation] アルドール縮合反応促進による長波長UV吸収リグニン酸化銅分解物の効率生産2020

    • Author(s)
      土田哲平、渡辺隆司、三亀啓吾
    • Organizer
      第70回日本木材学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生理活性発現を目指したリグニンの分子設計と分解物の機能2020

    • Author(s)
      渡辺くるみ、渡辺隆司、舩岡正光、三亀啓吾
    • Organizer
      第70回日本木材学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The facilitation of aldol condensation for lignin alkaline cupric (II) oxidation products having long-wavelength UV absorption2019

    • Author(s)
      T. Tsutida, T.Watanabe K. Mikame
    • Organizer
      29th Annual Meeting of MRS-J
    • Related Report
      2019 Research-status Report
  • [Presentation] Molecular design for physiologically active compounds from lignin by oxidative degradation2019

    • Author(s)
      K. Watanabe, Y. Kuboi, T.Watanabe, S. Sato, M. Funaoka, K. Mikame
    • Organizer
      29th Annual Meeting of MRS-J
    • Related Report
      2019 Research-status Report
  • [Presentation] 高脂肪食を摂取したマウスの腎障害に及ぼす天然リグニン由来低分子リグノフェノールの影響2019

    • Author(s)
      杉澤春奈, 乗鞍敏夫, 三亀啓吾, 山口満里奈, 鹿野綾乃, 高橋なごみ, 山岡伸, 向井友花, 佐藤伸
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 酸化銅分解による長波長UV吸収リグリンオリゴマーの選択的生産2018

    • Author(s)
      佐藤賢矢、三亀啓吾、渡辺隆司
    • Organizer
      第68回日本木材学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] The effect of alkaline cupric (II) oxidation conditions for lignin oligomers having long-wavelength UV absorption2018

    • Author(s)
      K. Mikame, K. Sato, T.Watanabe
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Derivative of physiologically active compounds from uniformized lignin by oxidative degradation2018

    • Author(s)
      K. Mikame, S Kiuchi Y. Kuboi, T.Watanabe, M. Funaoka
    • Organizer
      第28回日本MRS年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 構造均一化リグニンの酸化分解とその分解物の抗酸化活性2018

    • Author(s)
      三亀啓吾, 木内咲来, 久保井友夏梨, 渡辺隆司, 舩岡正光
    • Organizer
      第69回日本木材学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 酸化銅分解による長波長UV 吸収リグニンオリゴマーの選択的生産2018

    • Author(s)
      佐藤賢矢、三亀啓吾、渡辺隆司
    • Organizer
      第68回 日本木材学会大会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi