Creation of Suparmolecular Catalyts by Design of Functionalized Molecular Blocks and Reaction Field

• Project/Area Number: 17K08225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tokyo University of Science
• Principal Investigator: Aoki Shin 東京理科大学, 薬学部生命創薬科学科, 教授 (00222472)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 超分子 / 自己集積 / 酵素モデル / リン酸エステル / 加水分解 / 触媒 / 二相系溶媒 / リン酸モノエステル / 二相系 / 亜鉛錯体 / 銅イオン / 金属錯体

Outline of Final Research Achievements

The progress of supramolecualr chemistry based on the artificial molecular assembly is remarkable. However, the examples of supermolecules having a catalytic function are limited. In this study, we constructed an enzyme-like active center by the three-dimensional assembly of molecular building blocks Typically, we designed and synthesized the supramolecular complexes, which possess a metal active center and catalytic functional groups, by the combination of a bis(zinc-cyclen) complex having only one long-chain alkyl group, chemically modified barbital derivatives, and copper ions in two-phase solvent systems. It was found that the hydrolysis reaction of phosphate monoester was accelerated by the supramolecular complexes in a catalytic manner.

Academic Significance and Societal Importance of the Research Achievements

自然界に存在する酵素は、特定の基質を認識して反応し、触媒回転するが、触媒機構は不明である。本研究は、酵素モデルを様々な分子部品を組わ合わせて自己集積させて構築すること、二相系溶媒（有機溶媒／水）によって反応を行ったこと、二相系の人工的反応であるにも関わらず、天然酵素と同様の速度論的法則（Michaelis-Menten速度論）に従うこと、反応が触媒回転することなどを明らかにした。天然酵素による触媒的反応機構の物理化学的理解の一端になるものと考えられる。

Research Products

• [Journal Article] One-Pot Synthesis of Cyclic Oligosaccharides by the Polyglycosylation of Monothioglycosides (2020)
  • Author(s): Hidetoshi Someya, Takehito Seki, Gota Ishigami, Taiki Itoh, Yutaka Saga, Yasuyuki Yamada, Shin Aoki
  • Journal Title: Carbohydrate Research Volume: 487 Pages: 107888-107888
  • DOI: 10.1016/j.carres.2019.107888
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unprecedented Formation of Palladium(II)-Pyrazole Based Thiourea from Chromone Thiosemicarbazone and [PdCl2(PPh3)2]: Interaction with Biomolecules and Apoptosis through Mitochondrial Signaling Pathway (2020)
  • Author(s): H. Jebiti, C. Balachandran, M. Muthu T. Y. Arun, N. S. P. Bhuvanesh, S. Aoki, and R. Karvembu
  • Journal Title: J. Inorg. Biochem Volume: 205 Pages: 110988-110988
  • DOI: 10.1016/j.jinorgbio.2019.110988
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Iron Oxide Nanoparticle Core-Sell Magnetic Microspheres: Applications toward Targeted Drug Delivery (2020)
  • Author(s): S. Ayyanaar, M. P. Kesavan, C. Balachandran, S. Rasala, S. Aoki, J. Rajesh, T. Webster, G. Rajagopal
  • Journal Title: Nanomed. Nanotech. Biol. Med., Volume: 24
  • Peer Reviewed / Open Access
• [Journal Article] Simple and Convenient Method for the Isolation, Culture, and Re-collection of Cancer Cells from Blood by Using Glass-Bead Filters (2019)
  • Author(s): B. Shashni, H. Matsuura, R. Saito, T. Hirata, S. Ariyasu, K. Nomura, H. Takemura, K. Akimoto, N.Aikawa, A. Yasumori and S. Aoki,
  • Journal Title: ACS Biomater. Sci. Eng. Volume: 5 Issue: 2 Pages: 438-452
  • DOI: 10.1021/acsbiomaterials.8b01335
  • Peer Reviewed / Open Access
• [Journal Article] Stereoselective aldol reactions of dihydroxyacetone derivatives catalyzed by chiral Zn2+ complexes (2019)
  • Author(s): Yasuda Masato、Saga Yutaka、Tokunaga Takuya、Itoh Susumu、Aoki Shin
  • Journal Title: Tetrahedron Volume: 75 Issue: 6 Pages: 757-777
  • DOI: 10.1016/j.tet.2018.12.060
  • Peer Reviewed / Open Access
• [Journal Article] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Phosphatases Formed from a Monoalkylated Dizinc(II) Complex, Cyclic Diimide Units, and Copper(II) in Two-Phase Solvent System (2019)
  • Author(s): Rahman Akib Bin、Imafuku Hiroki、Miyazawa Yuya、Kafle Ananda、Sakai Hideki、Saga Yutaka、Aoki Shin
  • Journal Title: Inorganic Chemistry Volume: 58 Issue: 9 Pages: 5603-5616
  • DOI: 10.1021/acs.inorgchem.8b03586
  • Peer Reviewed / Open Access
• [Journal Article] Highly Active Copper(I) Complexes of Aroylthiourea Ligands Against Cancer Cells; Synthetic and Biological Studies (2019)
  • Author(s): Kumaramangalam Jeyalakshmi, Jebiti Haribabu, Chandrasekar Balachandran, Eswaramoorthi Narmatha, Nattamai S. P. Bhuvanesh, Shin Aoki, and Ramasamy Karvembu
  • Journal Title: New Journal of Chemistry Volume: none Issue: 7 Pages: 3188-3198
  • DOI: 10.1039/c8nj04246b
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Complexes Formed by the Self-Assembly of a Hydrophobic Bis(Zn2+-cyclen) Complex, Copper, and Barbital Units That Are Functionalized with Amino Acids in a Two-Phase Solvent System (2019)
  • Author(s): Yuya Miyazawa, Akib Bin Rahaman, Yutaka Saga, Hiroki Imafuku, Yosuke Hisamatsu, Shin Aoki
  • Journal Title: Micromachines Volume: 10 Issue: 7 Pages: 452-452
  • DOI: 10.3390/mi10070452
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Design, synthesis, and anticancer activity of iridium(III) complex-peptide hybrids that contain hydrophobic acyl groups at the N-terminus of the peptide units (2019)
  • Author(s): Naito Kana、Yokoi Kenta、Balachandran Chandrasekar、Hisamatsu Yosuke、Aoki Shin
  • Journal Title: Journal of Inorganic Biochemistry Volume: 199 Pages: 110785-110785
  • DOI: 10.1016/j.jinorgbio.2019.110785
  • Peer Reviewed
• [Journal Article] Evaluation of Zn2+ Coordination Structures in Chiral Zn2+ Complexes Based on Shape Measurement Factors: Relationships between Catalytic Activity and the Coordination Structure (2019)
  • Author(s): Shin Aoki, Chiharu Kikuchi, Yuichi Kitagawa, Yasuchika Hasegawa, Syotaro Sonoike, Yutaka Saga, Miho Hatanaka
  • Journal Title: Eur. J. Org. Chem. Volume: 44 Issue: 44 Pages: 4740-4751
  • DOI: 10.1002/ejic.201900934
  • Peer Reviewed / Open Access
• [Journal Article] NHC Catalyzed Green Synthesis of Functionalized Chromones: DFT Mechanistic Insights and in vitro Activities in Cancer Cells (2019)
  • Author(s): N. Murugesh, J. Haribabu, K. Arumugam, C. Balachandran, R.Swaathy, S. Aoki, A. Sreekanth, R. Karvembu, and S. Vedachalam
  • Journal Title: New J. Chem. Volume: none Issue: 34 Pages: 13509-13525
  • DOI: 10.1039/c9nj02650a
  • Peer Reviewed / Open Access
• [Journal Article] A New Class of beta-Pyrrolidino-1,2,3-triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological and Docking Studies (2019)
  • Author(s): K. Easwaramoorthi, J. A. Rajendran, K. C. Rao, C. Balachandran, Y. Arun, S. M. Mahalingam, N. Arumugam, A. I. Almansour, R. S. Kumar, D. M. Al-thamili, S. Aoki,
  • Journal Title: Molecules Volume: 24 Issue: 19 Pages: 3501-3501
  • DOI: 10.3390/molecules24193501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Design and Green Synthesis of Novel Benzotriazoloquinolinyl Spirooxindolopyrrolizidines: Antimycobacterial and Antiproliferative Studies (2019)
  • Author(s): V. Pogaku, V. S. Krishna, C. Balachandran, K. Rangan, D. Sriram, S. Aoki, S. Basavoju
  • Journal Title: New J. Chem. Volume: 43 Issue: 44 Pages: 17511-17520
  • DOI: 10.1039/c9nj03802g
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Size-Based Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted by a Cell-Recognition PC Software (2018)
  • Author(s): Shashni B, Ariyasu S, Takeda R, Suzuki T, Shiina S, Akimoto K, Maeda T, Aikawa N, Abe R, Osaki T, Itoh N, Aoki S.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Issue: 4 Pages: 487-503
  • DOI: 10.1248/bpb.b17-00776
  • NAID: 130006602538
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Stereospecific Synthesis of Tris-heteroleptic Tris-cyclometalated Iridium(III) Complexes via Different Heteroleptic Halogen-Bridged Iridium(III) Dimers and Their Photophysical Properties (2018)
  • Author(s): Yuichi Tamura, Yosuke Hisamatsu, Ayami Kazama, Kenji Yoza, Kyouhei, Sato, Reiko Kuroda, Shin Aok
  • Journal Title: Inorganic Chemistry Volume: 57 Issue: 8 Pages: 4571-4589
  • DOI: 10.1021/acs.inorgchem.8b00323
  • Peer Reviewed
• [Journal Article] Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides (2018)
  • Author(s): Hidehisa Someya, Taiki Itoh, Mebae Kato, and Shin Aoki
  • Journal Title: Journal of Visualized Experiments (JoVE) Volume: none Issue: 137
  • DOI: 10.3791/57897
  • Peer Reviewed
• [Journal Article] Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-type Cell Death (2018)
  • Author(s): Abdullah-Al Masum, Yosuke Hisamatsu, Kenta Yokoi, and Shin Aoki
  • Journal Title: Bioinorganic Chemistry and Applications Volume: 2018 Pages: 1-18
  • DOI: 10.1155/2018/7578965
  • Peer Reviewed / Open Access
• [Journal Article] Design and Synthesis of a Luminescent Iridium Complex-Peptide (IPH) that Detects Cancer Cells and Induces Their Apoptosis (2018)
  • Author(s): Abdullah-Al Masum, Kenta Yokoi, Yosuke Hisamatsu, Kana Naito, Babita Shashni, and Shin Aoki,
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 26 Issue: 17 Pages: 4804-4816
  • DOI: 10.1016/j.bmc.2018.08.016
  • Peer Reviewed
• [Journal Article] Design and Synthesis of Boron Containing Monosaccharides by the Hydroboration of D-Glucal for Use in Boron Neutron Capture Therapy (BNCT) (2018)
  • Author(s): Taiki Itoh, Kei Tamura, Hiroki Ueda, Tomohiro Tanaka, Kyouhei Satoh, Reiko Kuroda, and Shin Aoki
  • Journal Title: Bioorganic & Medicinal Chemistry Volume: 26 Issue: 22 Pages: 5922-5933
  • DOI: 10.1016/j.bmc.2018.10.041
  • Peer Reviewed
• [Journal Article] A chemical modulator of p53 transactivation that acts as a radioprotective agonist. (2018)
  • Author(s): Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi and Toshiya Inaba
  • Journal Title: Molecular Cancer Therapeutics Volume: 17 Issue: 2 Pages: 432-442
  • DOI: 10.1158/1535-7163.mct-16-0554
  • NAID: 120006552353
  • Peer Reviewed / Open Access
• [Journal Article] Concise and Versatile Synthesis of Sulfoquinovosyl Acyl Glycerol Derivatives for Biological Applications (2017)
  • Author(s): Tomohiro Tanaka, Yasuhiro Sawamoto, and Shin Aoki
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 65 Issue: 6 Pages: 566-572
  • DOI: 10.1248/cpb.c17-00135
  • NAID: 130005686027
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Design, Synthesis and Anticancer Activity of Cyclometalated Tris(ppy) Iridium (III) Complexes Having the Cationic Peptides at the 4’-Position of Ppy Ligand (ppy = 2-phenylpyridine) (2017)
  • Author(s): Kenta Yokoi, Yosuke Hismaatsu and Shin Aoki
  • Journal Title: European Journal of Inorganic Chemistry Volume: (44) Issue: 44 Pages: 5295-5309
  • DOI: 10.1002/ejic.201700846
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis of Disaccharide Nucleosides Utilizing the Temporary Protection of the 2’,3’-cis-Diol of Ribonucleosides by a Boronic Ester (2017)
  • Author(s): Hidehisa Someya, Taiki Itoh, and Shin A
  • Journal Title: Molecules Volume: 22 Issue: 10 Pages: 1650-1650
  • DOI: 10.3390/molecules22101650
  • Peer Reviewed / Open Access
• [Presentation] 672.Design and Synthesis of Artificial Phosphatases Formed by the Self-Assembly of Monoalkylated Dizinc(II) Complex, Copper, and Diimide Units Functionalized with Lewis Acid or Crown Ether Moities (2020)
  • Author(s): Akib Bin Rahman, Yuya Miyazawa, and Shin Aoki
  • Organizer: 7th International Postgraduate Conference on Pharmaceutical Sciences 2020 (iPoPS2020)、2/27~2/28、2020, Noda, Japan
  • Invited
• [Presentation] Design and Synthesis of Supramolecular Complexes Formed by the Self-Assembly of Monoalkylated Dizinc(II) Complex, Copper, and Diimide Units with Lewis Acid or Crown Ether Moieties (2020)
  • Author(s): Akib Bin Rahman, Yuya Miyazawa, and Shin Aoki
  • Organizer: Akib Bin Rahman, Yuya Miyazawa, and Shin Aoki
  • Invited
• [Presentation] 2.モノアルキル化された二核亜鉛錯体と有機分子ブロックの自己集積による超分子ホスファターゼの設計・合成とリン酸モノエステル加水分解活性 (2019)
  • Author(s): 青木 伸、Akib Bin Rahman、宮澤 有哉、嵯峨 裕
  • Organizer: 第17回ホストゲスト・超分子化学シンポジウム
• [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Peptide Hybrids for the Induction of Cancer Cell Death (2019)
  • Author(s): Shin Aoki
  • Organizer: The 9th World Congress on Chemistry and Medicinal Chemistry (WCC2019)
  • Int'l Joint Research / Invited
• [Presentation] 23.Design, Synthesis, and Phosphatase Activities of Supramolecular Complexes Inspired by an Active Center of Alkaline Phosphatase (2019)
  • Author(s): Yuya Miyazawa, Yutaka Saga, Akib Bin Rahman, Hiroki Imafuku, Shin Aoki
  • Organizer: 錯体化学会第69回討論会
• [Presentation] 25.Design and Synthesis of Metallosupramoelcular Catalysts in Two-Phase Solvent Systems that Mimic Natural Enzymes (2019)
  • Author(s): Shin Aoki
  • Organizer: 7th Asian Congress on Coordination Chemistry (ACCC7)
  • Int'l Joint Research / Invited
• [Presentation] 646.Design and Synthesis of Tetrakis(Zn2+-cyclen) Complex Bridged with an Alkyl Chain for the Contruction of Supramolecular Phosphatase by Self-Assembly with Barbital and Copper(II) (2019)
  • Author(s): Yuka Kobayashi, Akib Bin Rahman, Yuya Miyazawa, Yutaka Saga, and Shin Aoki
  • Organizer: 7th Asian Congress on Coordination Chemistry (ACCC7)
  • Int'l Joint Research
• [Presentation] 659.Design & Synthesis of Supramolecular Phosphatases Based on Self-Assembly of Molecular Building Blocks & Mechanistic Study by Means of Imaging of Reaction Mixtures (2019)
  • Author(s): Akib Bin Rahman, Yuya Miyazawa, Ananda Kafle, Hideki Sakai, Yutaka Saga, and Shin Aoki
  • Organizer: 東京理科大学総合研究院イメージングフロンティアセンターシンポジウム
• [Presentation] Development of New Boron Compounds for Biomedical Sciences by Means of Traditional rRactions of Sugar Derivatives (2019)
  • Author(s): Shin Aoki, Taiki Itoh, Hidehisa Someya, Hiroki Ueda, Kosuke Mizuno
  • Organizer: 2019 International Biomedical Interface Symposium (2019IBMI)
  • Invited
• [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes Based on Post-Complexation Functionalization for Photochemistry and Chemical Biology (2019)
  • Author(s): Shin Aoki
  • Organizer: Invited Seminar at National Tsing Hua University
  • Invited
• [Presentation] ell Death Induction of Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and Mechanism (2019)
  • Author(s): 青木 伸、横井 健汰、内藤 佳奈、Chandrasekar Balachandran
  • Organizer: 日本化学会第99春季年会
• [Presentation] Mechanistic Study of Cell Death of Cancer Cells Induced by Cyclometalated Iridium(III)-Peptide Hybrids (IPHs) (2019)
  • Author(s): Chandrasekar Balachandran, Kenta Yokoi, Kana Naito, Shin Aoki
  • Organizer: 日本薬学会第139年会
• [Presentation] アミノ酸で修飾したバルビタール誘導体・二核亜鉛錯体・銅イオンの自己集積型超分子の設計、合成とphosphatase活性 (2019)
  • Author(s): 宮澤 有哉、Akib Bin Rahman、今福 浩輝、嵯峨 裕、青木 伸
  • Organizer: 日本薬学会第139年会
• [Presentation] 新規二核亜鉛錯体、イミド誘導体、銅から成る自己集積的多核銅錯体の構築と反応活性 (2018)
  • Author(s): 嵯峨 裕、宮澤 有哉、青木 伸
  • Organizer: 第16回ホストゲスト・超分子化学シンポジウム
• [Presentation] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Phosphatase Formed from Monoalkylated Dizinc(II) Complex, Diimide Units & Copper(II) in Two-Phase Solvent System (2018)
  • Author(s): Akib Bin Rahman, Hiroki Imafuku, Yuya Miyazawa, Yutaka Saga, Shin Aoki
  • Organizer: 第16回ホストゲスト・超分子化学シンポジウム
• [Presentation] がん細胞死誘導活性を有するシクロメタレート型Ir(III)錯体;ペプチドハイブリッドの設計とメカニズム解析 (2018)
  • Author(s): 内藤 佳奈、久松 洋介、横井 健汰、吉原利忠、飛田成史、青木 伸
  • Organizer: 日本ケミカルバイオロジー学会第12回年会
• [Presentation] シクロメタレート型イリジウム（III）錯体－塩基性ペプチドハイブリッドのがん細胞死誘導活性に対するペプチドの影響 (2018)
  • Author(s): 青木 伸、横井 健汰、内藤 佳奈、Abdullah-Al Masum、久松 洋介
  • Organizer: 第28回金属の関与する生体関連反応シンポジウム
• [Presentation] Selective Synthesis of Tris-cyclometalated Tris-Heteroleptic Iridium(III) Complexes Based on Zn2+-Promoted Degradation Reaction of Ir Complexes and Their Photophysical Properties (2018)
  • Author(s): Shin Aoki, Yuichi Tamura, Ayami Kazama, Kennichi Yoza, Kyohei Sato, Reiko Kuroda, Yosuke Hisamatsu
  • Organizer: 錯体化学会第68回討論会
• [Presentation] Asymmetric Aldol Reactions of Acetone and Benzaldehydes Catalyzed by Chiral Zn2+ Complexes: Computational Study of Relationship between Structures and Reactivity of the Complexes (2018)
  • Author(s): Shotaro Sonoike, Shin Aoki, Chiharu Kikuchi, Miho Hatanaka, Yuichi Kitagawa, Yasuchika Hasegawa
  • Organizer: 錯体化学会第68回討論会
• [Presentation] シクロメタレート型イリジウム錯体(Ⅲ)と発光団ハイブリッド錯体の設計・合成と発光特性 (2018)
  • Author(s): 風間 彩水、湯浅 順平、青木 伸
  • Organizer: 錯体化学会第68回討論会
• [Presentation] Design & Synthesis of Cyclometalated Iridium Complexes for Biomedical and Material Sciences (2018)
  • Author(s): Shin Aoki, Yosuke Hisamatsu, Yuichi Tamura, Kenta Yokoi, Kana Naito, Abdullah-Al Masum
  • Organizer: 43rd International Conference on Coordination Chemistry (ICCC2018)
  • Invited
• [Presentation] Design & Synthesis of Boron-Containing Sugar Derivatives for Boron Neutron Capture Therapy (2018)
  • Author(s): Taiki Itoh, Hiroki Ueda, Kei Tamura, Kosuke Mizuno, Yasuhiro Sawamoto, Tomohiro Tanaka, Shin Aoki
  • Organizer: 43rd International Conference on Coordination Chemistry (ICCC2018)
• [Presentation] Design and Synthesis of Supramolecular Phosphatases Mimicking an Active Center of Alkaline Phosphatase (2018)
  • Author(s): Yuya Miyazawa, Akib Bin Rahman, Hiroki Imafuku, Shin Aoki
  • Organizer: 43rd International Conference on Coordination Chemistry (ICCC2018)
• [Presentation] Design & Synthesis of Cyclometalated Iridium Complexes Controlling Apoptosis and Necroptosis (2018)
  • Author(s): Kenta Yokoi, Kana Naito, Abdullah-Al Masum, Shin Aoki
  • Organizer: 43rd International Conference on Coordination Chemistry (ICCC2018)
• [Presentation] Recent Development of Zinc Chemistry; Zinc Supramolecular Chemistry and Zn-promoted Reactions- (2018)
  • Author(s): Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
  • Invited
• [Presentation] O-Glycosylation Utilizing Boronic Ester for Synthesis of Disaccharide Nucleosides and Oligosaccharides (2018)
  • Author(s): Hidetoshi Someya, Taiki Itoh, Mebae Katoh, Ryota Naoi, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Phosphatase Fomred by Complexation of Monoalkylated Dizinc(II) Complex, Dimide Units & Copper(II) (2018)
  • Author(s): Akib Bin Rahman, Hiroki Imafuku, Yuya Miyazawa, Yutaka Saga, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] Design and Synthesis of Chemical Linkers to Modify Magnetic Beads for Capture and Isolation of Target Cells (2018)
  • Author(s): Makito Kayano, Makito Kayano, Hiroto Kuchiishi, Kazue Matsumoto, Babita Shashni, Reisa Takeda, Yuto Mukai, Ryo Abe, Hideki Sakai, Tomohiro Tanaka, Satoshi Katayose, Nobuko Onoda, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] Design, Synthesis and Biological Evaluation of Boron Carriers based on Glucosamine Scaffolds for Boron Neutron Capture Therapy (2018)
  • Author(s): Hiroki Ueda, Hiroki Ueda, Taiki Itoh, Kosuke Mizuno, Tomohiro Tanaka, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] Design and Synthesis of Molecular Shuttles Driven by Phosphate-Zn(Ⅱ) Coordination (2018)
  • Author(s): Yoshiyuki Sekine, Yutaka Saga, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] Design and Synthesis of Cyclometalated Iridium(III)-Peptide Hybrids Inducing Different Types of Cell Death of Cancer Cells (2018)
  • Author(s): Kenta Yokoi, Kana Naito, Masum, Abdullah-Al, Shin Aoki
  • Organizer: 6th International Postgraduate Conference on Pharmaceutical Sciences 2018 (iPoPS2018)
• [Presentation] アミノ酸で修飾したバルビタール誘導体・二核亜鉛錯体・銅イオンの自己集積型超分子の設計、合成とphosphatase活性 (2018)
  • Author(s): 宮澤 有哉、Akib Bin Rahman、今福 浩輝、嵯峨 裕、青木 伸
  • Organizer: 第62回日本薬学会関東支部大会
• [Presentation] Supramolecular Complexes of a Monoalkylated Bis(Zinc(II)-Cyclen) Complex, Diimide Units & Copper(II) as Catalysts for Hydrolysis of Phosphate Monoester (2018)
  • Author(s): Akib Bin Rahman, Hiroki Imaffuku, Yuya Miyazawa, Shin Aoki
  • Organizer: 第62回日本薬学会関東支部大会
• [Presentation] Development of Boron-containing Monosaccharide Derivatives for Boron Neutron Capture Therapy. (2018)
  • Author(s): Taiki Itoh, Hiroki Ueda, Kei Tamura, Kosuke Mizuno, Balachandran Chandrasekar, Shin Aoki
  • Organizer: The 18th International Congress on Neutron Capture Therapy (ICNCT-18)
• [Presentation] Development of Supramolecular Complexes by Combinatorial Assembly of Functionalized Zinc(II) Complexes, Building Blocks and Metals. (2018)
  • Author(s): Shin Aoki, Akib Bin Rahman, Hiroki Imafuku, Yuya Miyazawa, Yuka Kobayashi, Yutaka Saga
  • Organizer: International Congress on Pure & Applied Chemistry Langkawi (ICPAC Langkawi 2018)
  • Invited
• [Presentation] ボロン酸エステルをヌクレオシド水酸基の一時的保護として利用した位置選択的Ｏ-グリコシル化反応による二糖ヌクレオシドの合成 (2018)
  • Author(s): 染谷英寿、伊藤太基、加藤萌、青木伸
  • Organizer: 第44回反応と合成の進歩シンポジウム
• [Presentation] 47.糖骨格をもつBNCTホウ素キャリアーの設計、合成とがん細胞への移行性 (2018)
  • Author(s): 青木伸、伊藤太基、上田大貴、水野皓輔、鈴木実、櫻井良憲
  • Organizer: 東京理科大学・日本医科大学第5回合同シンポジウム
• [Presentation] Photophysical and Biological Activity of Cyclometalated Iridium(III) Complex-Peptide Conjugates Synthesized by Post-Complexation Functionalization (2018)
  • Author(s): Shin Aoki, Kenta Yokoi, Kana Naito, Abdullah-Al Masum, Ayami Kazama, Yuki Imai, Junpei Yuasa
  • Organizer: 9th Asian Biological Inoganic Chemistry Conference (AsBIC9)
  • Invited
• [Presentation] Development of New Methods for Cancer Theranostics in Interdisciplinary Collaboration of Tokyo University of Science (2018)
  • Author(s): Shin Aoki, Babita Shashni, Kazunori Akimoto, Masanori Hayase, Hiroshi Takemura, Atsuo Yasumori, Naoyki Aikawa, Masato Kubo, and Masahiro Motosuke
  • Organizer: International Symposium of Tokyo University of Science, Translational Research (TR) Center -Frontiers in Developmental Strategy for Cancer Therapeutics-
  • Invited
• [Presentation] Design and Synthesis of Diverse Supramolecular Hosts and Catalysts by Assembly of Metal Complex Modules, Organic Builbing Blocks and Metals. (2018)
  • Author(s): Shin Aoki
  • Organizer: Pure and Applied Chemistry International Conference 2018 (PACCON 2018)
  • Int'l Joint Research / Invited
• [Presentation] 異分野連携研究による血液中のがん細胞の検出・捕捉・培養・細胞死誘導法の開発 (2018)
  • Author(s): 青木 伸
  • Organizer: 昭和薬科大学私立大学戦略的研究基盤形成支援事業公開シンポジウム
  • Invited
• [Presentation] リン酸-Zn(Ⅱ)配位結合を利用するロタキサン型分子シャトルの設計と合成 (2018)
  • Author(s): 関根 禎亮、嵯峨 裕、青木 伸
  • Organizer: 日本化学会第98春季年会
• [Presentation] 新規二核亜鉛錯体とバルビタール、銅から成る自己集積的多核銅錯体の構築と反応活性 (2018)
  • Author(s): 嵯峨 裕、宮澤 有哉、青木 伸
  • Organizer: 日本薬学会第138年会
• [Presentation] 不斉亜鉛触媒を用いるアルドール反応の立体選択性発現機構 (2017)
  • Author(s): 畑中 美穂、日下部 彩、青木 伸
  • Organizer: 第20回理論化学会討論会
• [Presentation] Development of New Methods for Diagnosis and Treatment of Cancer in Chemistry, Biochemistry and Material Sciences - Multidisciplinary Approach in Tokyo University of Science- (2017)
  • Author(s): Shin Aoki
  • Organizer: 5th International Postgraduate Conference on Pharmaceutical Sciences 2017 (iPoPS2017)
  • Int'l Joint Research / Invited
• [Presentation] Synthesis of Disaccharide Nucleosides and Oligosaccharides with Thioglycosyl Donors (2017)
  • Author(s): Taiki Itoh, Hidehisa Someya, Mebae Kato, and Shin Aoki
  • Organizer: [5th International Postgraduate Conference on Pharmaceutical Sciences 2017 (iPoPS2017)
• [Presentation] Design and Synthesis of Artificial TRAIL Mimics Based on C3-symmetric and Luminescent Iridium Complexes that are Able to Stain and Induce Cell Death of Cancer Cells (2017)
  • Author(s): Abdullah-Al Masum, Yosuke Hisamasu, Nozomi Suzuki, Shin Aoki（
  • Organizer: 第15回次世代を担う有機化学シンポジウム
• [Presentation] モノアルキル化された二核亜鉛錯体と有機分子ブロックの自己集積による超分子ホスファターゼの設計・合成とリン酸モノエステル加水分解活性 (2017)
  • Author(s): 青木 伸、Akib Bin Rahman、今福 浩輝、宮澤 有哉、久松 洋介
  • Organizer: 第15回ホストゲスト・超分子化学シンポジウム
• [Presentation] モノアルキル化された二核亜鉛錯体と有機ブロック、銅イオンの自己集積化による超分子ホスファターゼの設計と合成 (2017)
  • Author(s): Akib Bin Rahman、Hiroki Imafuku、Yosuke Hisamatsu、Yuya Miyazawa、Shin Aoki
  • Organizer: 第27回金属の関与する生体関連反応シンポジウム (SRM2017)
• [Presentation] 立体選択的アルドール反応のためのクリプタンド型キラル亜鉛錯体触媒の設計と合成 (2017)
  • Author(s): 菊地 千陽、安田 真人、畑中 美穂、北川 裕一、園池 昇太郎、長谷川 靖哉 、青木 伸
  • Organizer: 第27回金属の関与する生体関連反応シンポジウム (SRM2017)
• [Presentation] 11B NMR/MRI of Copper (II) Ions in Vitro Based on the Full Decomposition of o-Carborane Derivatives under Physiological Conditions (2017)
  • Author(s): Shin Aoki, Tomohiro Tanaka, Rikita Araki, Takaomi Saido, Ryo Abe
  • Organizer: International Symposium on Imaging Frontier (ISIF2017)
  • Int'l Joint Research
• [Presentation] Detection and Induction of Cell Death of Cancer Cells by Luminescent Iridium Complexes Having Death Receptor Binding Peptides (2017)
  • Author(s): Abdullah-Al Masum, Yosuke Hisamatsu, Nozomi Suzuki, and Shin Aoki
  • Organizer: 17th Asian Chemical Congress (17ACC)
  • Int'l Joint Research
• [Presentation] Development of Regioselective O-Glycosylation reaction for Synthesis of Disaccharide Nucleosides (2017)
  • Author(s): Hidehisa Someya, Taiki Itoh, and Shin Aoki
  • Organizer: 17th Asian Chemical Congress (17ACC)
  • Int'l Joint Research
• [Presentation] Development of Functionalized Iridium Complexes for Biological and Material Sciences (2017)
  • Author(s): Shin Aoki
  • Organizer: 6th Asian Conference on Coordination Chemistry (ACCC6)
  • Int'l Joint Research / Invited
• [Presentation] Selective Cell Death Induction of Cancer Cells of Metal Complexes (2017)
  • Author(s): Jun Jie Zhu, Yosuke Hisamatsu, Shin Aoki
  • Organizer: 6th Asian Conference on Coordination Chemistry (ACCC6)
  • Int'l Joint Research
• [Presentation] Phosphate Monoester Hydrolysis by Supramolecular Phosphatase Formed by Zinc(II) Complex-Organic Block-Cu(II) (2017)
  • Author(s): Akib Bin Rahman, Yosuke Hisamatsu, Hiroki Imafuku, Yuya Miyazawa, Shin Aoki
  • Organizer: 6th Asian Conference on Coordination Chemistry (ACCC6)
  • Int'l Joint Research
• [Presentation] Supramolecular Catalysts by Self-assembly of Metal Complexes & Organic Modules (2017)
  • Author(s): Shin Aoki, Yosuke Hisamatsu, Akib Bin Rahman, Hiroki Imafuku, Yuya Miyazawa
  • Organizer: 18th Tetrahedron Symposium Asia Edition
  • Int'l Joint Research
• [Presentation] Convenient Methods for Detection and Capture of Circulating Tumor Cells (2017)
  • Author(s): Shin Aoki, Babita Shashni, Hidehiko Matsuura, Kenta Nomura, Takuto Maeda, Shota Shiina, Kazunori Akimoto, Hiroshi Takemura, Atsuo Yasumori, et al.
  • Organizer: 9th AFMC International Medicinal and Chemical Symposium (AIMEC2017)
  • Int'l Joint Research
• [Presentation] Predicting Radiation Protection and Toxicity of p53 Targeting Radioprotectors using Machine Learning (2017)
  • Author(s): Masataka Kimura, Shin Aoki and Hayato Ohwada
  • Organizer: IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (IEEE CIBCB 2017)
  • Int'l Joint Research
• [Presentation] シクロメタレート型イリジウム錯体－ペプチドハイブリッドによるがん細胞の検出と細胞死誘導 (2017)
  • Author(s): 青木 伸、Abdullah-Al Masum、久松 洋介、内藤佳奈、横井 健汰
  • Organizer: 2017年光化学討論会
• [Presentation] 亜鉛イオンの配位構造に着目した架橋型キラル亜鉛錯体触媒の設計と合成 (2017)
  • Author(s): 菊地 千陽、安田 真人、畑中 美穂、北川 裕一、園池 昇太郎、長谷川 靖哉 、青木 伸
  • Organizer: 第61回日本薬学会関東支部大会
• [Presentation] シクロメタレート型イリジウム（III）錯体－塩基性ペプチド ハイブリッドのがん細胞死誘導活性に対するペプチド導入位置の影響の検討 (2017)
  • Author(s): 横井 健汰、内藤 佳奈、久松 洋介、青木 伸
  • Organizer: 第61回日本薬学会関東支部大会
• [Presentation] Design and Synthesis of Supramolecular Phosphatases Based on Self-assembly of Monoalkylated Dizinc(II) Complexes, Diimide Units, & Copper(II) for Catalytic Hydrolysis of Phosphate Monoester (2017)
  • Author(s): Akib Bin Rahman, Hiroki Imafuku, Yosuke Hisamatsuu, Yuya Miyazaw, Yutaka Saga, Shin Aoki
  • Organizer: 錯体化学会第67回討論会
• [Presentation] 血中循環がん細胞（CTC）の分離システムの開発 (2017)
  • Author(s): 青木 伸
  • Organizer: BioJapan 2017
  • Invited
• [Presentation] Synthesis of Disaccharide Nucleosides Utilizing the Temporary Protection of the 2’,3’-cis-Diol of Ribonucleosides by a Boronic Ester (2017)
  • Author(s): Hidehisa Someya, Taiki Itoh, Shin Aoki
  • Organizer: International Symposium on Biological Chemistry (ISBC2017)
  • Int'l Joint Research
• [Remarks] 東京理科大学薬学部ホームページ
  • URL: https://www.rs.noda.tus.ac.jp/aokilab/
• [Remarks] 青木研究室ホームページ
  • URL: https://www.rs.noda.tus.ac.jp/aokilab/
• [Remarks] 東京理科大学薬学部生命創薬科学科 青木研究室
  • URL: http://www.rs.noda.tus.ac.jp/aokilab/index.html