| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The diterpenoids distributed in the plants of Thymelaeaceae and Euphorbiaceae families are rich in the chemical and biological diversity. In the present study, we collected plants belonging to Thymelaeaceae and Euphorbiaceae families from Japan and China, and constructed a plant extract library. Further chemical investigations were carried out. As a result, a number of novel diterpenoids with potent anti-HIV activities were isolated. Their structures were established by extensive physicochemical and spectroscopic analyses. Furthermore, semisynthesis of the derivatives of the natural diterpenoids disclosed the structure-activity relationship and provided optimized lead compounds towards novel anti-HIV drug discovery.
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