| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we focused on the molecular structure of bioactive polyunsaturated fatty acids for drug discovery research based on stable equivalents of resolvins and started this research for the purpose of developing a tool to analyze the mechanism of action of resolvins using chemical probes.
Two units of resolvin E2 (CP-RvE2) with cyclopropane, which is a stable equivalent of resolvin E2, and a new azide unit were prepared. We succeeded in synthesizing 18-azidopropoxy-CP-RvE2 and 20-azidopropoxy-CP-RvE2 using the Sonogashira coupling as the key reaction.
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