Development of novel preventive method for cisplatin-induced nephrotoxicity with drug-drug interaction
| Project/Area Number |
17K08412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University (2019)
Mie University (2017-2018) |
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Principal Investigator |
OKUDA Masahiro 大阪大学, 医学部附属病院, 教授 (70252426)
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| Co-Investigator(Kenkyū-buntansha) |
岩本 卓也 三重大学, 医学部附属病院, 准教授 (30447867)
水野 聡朗 三重大学, 医学部附属病院, 講師 (60378411)
池村 健治 三重大学, 医学部附属病院, 薬剤師 (70513935)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | シスプラチン / 腎障害 / 有機カチオントラスポータ２ / プロトンポンプ阻害薬 / ランソプラゾール / 有機カチオントランスポータ２ / 有機アニオントランスポータ３ / 薬物間相互作用 / OCT2 / PPI |
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| Outline of Final Research Achievements |
Our study demonstrated that co-administration of lansoprazole (LPZ), a proton pump inhibitor, ameliorated cisplatin (CDDP)-induced nephrotoxicity by decreased renal accumulation of CDDP through inhibition of organic cation transporter 2 (OCT2) in the kidney. Therefore, the present findings provided important information for the establishment of novel protective approaches to minimize CDDP-induced nephrotoxicity.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、長年にわたり回避することが困難であったシスプラチンの腎障害に対する支持療法構築に向けた有用な新知見であると考えられる。さらに、臨床への還元を意識し、安全性が認められている既存薬から新たな使用方法を見つけ出すドラッグリポジショニングという研究概念も兼ね揃えており、社会的意義の高い研究である。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.2019
Author(s)
Tachibana Ryota, Umekawa Takashi, Yoshikawa Kento, Owa Takao, Magawa Shoichi, Furuhashi Fumi, Tsuji Makoto, Maki Shintaro, Shimada Kyoko, Kaneda K. Michiko, Nii Masafumi, Tanaka Hiroaki, Tanaka Kayo, Kamimoto Yuki, Kondo Eiji, Kato Ineko, Ikemura Kenji, Okuda Masahiro, et al.
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 234-234
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study.2017
Author(s)
Ikemura K, Oshima K, Enokiya T, Okamoto A, Oda H, Mizuno T, Ishinaga H, Muraki Y, Iwamoto T, Takeuchi K, Katayama N, Okuda M
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Journal Title
Cancer Chemotherapy and Pharmacology
Volume: 印刷中
Issue: 5
Pages: 943-949
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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