| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Analysis of the localization of DGKepsilon (DGKe) in the central nervous system revealed that DGKe was expressed in hippocampus, cerebral cortex and striatal projection neurons, but not in interneurons. We also newly reported that DGKzeta (DGKz) localizes to the nuclei of outer hair cells in the cochlea and translocates from the nucleus to the cytoplasm by acoustic stimulation. It was revealed that DGKgamma (DGKg) is localized in the Golgi apparatus and DGKe is expressed in the endoplasmic reticulum in zona glomerulosa cells of the adrenal gland. The abundant expression of DGK isozymes in the peripheral organs as well as central nervous system and the localization changes upon external stimulation suggest that this enzyme may have an important role in cell function.
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