| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Extracellular matrix alters according to the tissues and its development. The actin-binding proteins involved in cell morphology and cell migration have a role in the functional and morphological changes of the cells depend on the differences in the extracellular matrix. One molecule that localizes at the intracellular membrane site adhesion to the extracellular matrix, bound to FILIP, one of the actin-binding proteins, and decreased in the existence of FILIP. The inhibition of ROCK function blocked the decease of this molecule under the existence of FILIP. The blockage effect altered depends on the difference in the extracellular matrix. The extracellular matrix did not influence the growth rate of the brain-derived cells that have stemness. The cell density is important for the growth rate of the cells.
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