Study of the function and formation of sexually dimorphic nucleus
| Project/Area Number |
17K08567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 性的二型核 / 性ホルモン / 性分化 / 性差 / 思春期 / カルビンディン |
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| Outline of Final Research Achievements |
Nucleus exhibiting morphological sex differences are called sexual dimorphic nucleus. Physiological functions and formation mechanisms of sexually dimorphic nuclei are being studied for a long time; however, they have not yet been understood completely. The current study using rodent models showed that the sexually dimorphic nucleus of the preoptic area is involved in the control of sexual behavior. It was also found that testicular androgens and ovarian estrogens during the puberty play an important role in the formation of sexually dimorphic nuclei.
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| Academic Significance and Societal Importance of the Research Achievements |
性的二型核は、実験動物だけでなくヒトの脳にも存在する。本研究の成果は、単に実験動物の脳の性差を明らかにするのでなく、ヒトの脳の性差の理解に資するものである。本研究の成果を社会に発信することで、こころの性に関する理解が深まり、性的マイノリティに対する差別と偏見が無くなることが期待される。また、幾つかの神経疾患の罹患率には性差がある。このことは、疾患の発症メカニズムに性差があることを示唆しており、本研究の成果が疾患発症機構の解明に役立つ。
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Report
(5 results)
Research Products
(60 results)
