Clinical significance of chiral amino acid analysis in diabetic nephropathy/diabetic kidney disease
Project/Area Number |
17K08979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Kanazawa University |
Principal Investigator |
SHIMIZU Miho 金沢大学, 保健管理センター, 助教 (10547136)
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Project Period (FY) |
2017-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 糖尿病性腎症 / 糖尿病性腎臓病 / アミノ酸光学異性体 |
Outline of Final Research Achievements |
Analysis of the association between estimated glomerular filtration (eGFR) rate and albuminuria at baseline or during follow-up and risk of end-stage kidney disease showed the utility of eGFR slope in type 2 diabetes with diabetic nephropathy/diabetic kidney disease as a surrogate endpoint for the renal outcome. Analyses of renal structural-functional relationships and outcomes showed that the impact of hypertension and renal arteriosclerosis on renal and cardiovascular outcomes and the impact of low hemoglobin level and interstitial fibrosis/tubular atrophy on renal outcome and mortality in type 2 diabetes with biopsy-proven diabetic nephropathy. Furthermore, the clinical significance of chiral amino acid analysis in type 2 diabetes with diabetic nephropathy/diabetic kidney disease was suggested.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、糖尿病性腎症/糖尿病性腎臓病の臨床評価に有用な代替エンドポイント、組織機能連関が腎・心血管・生命予後に及ぼす影響に加えて、生体サンプルにおけるアミノ酸光学異性体測定の臨床的意義が示された。本研究の成果が、糖尿病性腎症/糖尿病性腎臓病の腎病変進展抑制ならびに予後改善に繋がることが期待される。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS.2018
Author(s)
Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima K, Matsui M, Yamauchi H, Gohda T, Fukami K et al
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Journal Title
Clin Exp Nephrol
Volume: 22
Issue: 2
Pages: 377-387
DOI
Related Report
Peer Reviewed / Open Access
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