The influence of resistin SNPs on glucose intolerance in general population
| Project/Area Number |
17K08985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川村 良一 愛媛大学, 医学系研究科, 講師 (90533092)
大沼 裕 東京女子医科大学, 医学部, 准教授 (00294794)
大澤 春彦 愛媛大学, 医学系研究科, 教授 (90294800)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / レジスチン / 一塩基多型(SNP) / 環境因子 / メチル化 / 生活習慣病 / 糖尿病新規発症 / インスリン抵抗性 / SNP / 遺伝学 |
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| Outline of Final Research Achievements |
To investigate the effect of epigenetics on glucose intolerance, we evaluated the association between DNA methylation status of CpG SNP-420 in resistin promoter and serum resistin levels in the general population with normal glucose tolerance. When SNP-420 was G/G genotype, CpG methylation was not observed, as the result, serum resistin levels were higher in subject with G/G genotype than C/C and C/G genotype. Furthermore, even in the subjects with normal glucose tolerance, BMI and insulin resistance were deteriorated in G/G genotype regardless of age and sex. These results suggest that, when the resistin CpG SNP-420 is G/G genotype, the lifestyle intervention from juvenile seems to be useful as a risk reduction of the onset of diabetes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、通常の健診では血糖が正常と判定されている一般住民が将来糖尿病に進展するリスク因子を明らかにすることができた。レジスチンプロモータのCpG-SNP420がG/G型の場合、生活環境による遺伝子転写抑制がないため、加齢や生活習慣によらない耐糖能異常発症のリスクであると思われる。更に、この集団において、ニューラルネットワークから得られた予測因子を組み合わせれば、より正確に将来糖尿病を発症する者を絞り込むことができると考えられる。従って、住民全員を対象とした生活指導から、これらの対象者に集中して早期から生活介入を行えば、費用対効果にすぐれた個別化予防医療となり得ると思われる。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES-DM study.2019
Author(s)
Sugimoto K, Tabara Y, Ikegami H, Takata Y, Kamide K, Ikezoe T, Kiyoshige E, Makutani Y, Onuma H, Gondo Y, Ikebe K, Ichihashi N, Tsuboyama T, Matsuda F, Kohara K, Kabayama M, Fukuda M, Katsuya T, Osawa H, Hiromine Y, Rakugi H.
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Journal Title
J Diabetes Investig.
Volume: 10:
Issue: 6
Pages: 1471-1479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association Between Heart Rate Variability and Home Blood Pressure: The Toon Health Study.2018
Author(s)
Saito I, Takata Y, Maruyama K, Eguchi E, Kato T, Shirahama R, Tomooka K, Kawamura R, Sano M, Tabara Y, Osawa H, Tanigawa T.
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Journal Title
Am J Hypertens.
Volume: 31
Issue: 10
Pages: 1120-1126
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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