| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We examined the anti-neuroinflammatory effects of Go-sha-jinki-Gan (GJG), a herbal medicine used in clinical practice, using a model of central nervous system disease. Using two animal models with different pathological mechanisms, a drug-induced Parkinson's disease model and a experimental autoimmune myelitis model, we confirmed biochemically and pathologically that GJG suppresses the expression of the proinflammatory cytokine TNFα by inhibiting p38 phosphorylation, and then inhibits the activation and aggregation of microglia and astrocytes. These results indicate that GJG inhibits neuroinflammation in the central nervous system by suppressing the phosphorylation of p38 in microglia through oral administration. These results were published in the journal Neurotherapeutics.
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