| Project/Area Number |
17K09467
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka Metropolitan University (2022)
Osaka City University (2017-2021) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | がん / 膵臓 / miRNA / メチル化 / エクソソーム / 内科 / 腫瘍 / 癌 |
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| Outline of Final Research Achievements |
Pancreatic cancer is an incurable cancer with a poor prognosis, and it is important to detect early-stage pancreatic cancer or patients who develop pancreatic carcinoma. Patients with intraductal papillary mucinous neoplasm (IPMN), which is considered a precancerous lesion of the pancreas, have a high frequency of not only pancreatic carcinogenesis but also carcinogenesis of other organs. Now, since miRNAs in exosomes, which are intercellular signaling molecules, exist in blood in a stable state, their analysis can reveal information about the cell from which they are released and may be effective in detecting IPMN patients who develop cancer. In addition, the genome-wide methylation analysis revealed genes that are highly methylated in cancerous lesions and only infrequently methylated in normal and non-cancerous lesions.
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| Academic Significance and Societal Importance of the Research Achievements |
膵癌は予後不良の難治癌である。定期的に人間ドックを受診しているにも関わらず、切除不能な膵癌が見つかることがあり、早期膵癌や膵発癌する受診者を正確に見つけることが重要である。膵臓の前癌病変と言われる膵管内乳頭粘液腫瘍(IPMN)では、膵発癌のみではなく他臓器発癌の頻度が高い。IPMN患者は発癌率が数%/年と高頻度であり、癌発見率(担癌比率)が0.3%と低い人間ドック受診者を対象にするよりも、医療経済的にも注目できる。また、IPMN患者は、決して稀な疾患ではない。血液から癌細胞由来のエクソソームを適切に分離することで超早期癌の診断ができ、発癌するIPMN患者を発見するのに有効と考えられた。
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