Diagnostic and therapeutic algorithm and biomarkers of chronic cough
| Project/Area Number |
17K09621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
Niimi Akio 名古屋市立大学, 医薬学総合研究院(医学), 教授 (30252513)
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| Co-Investigator(Kenkyū-buntansha) |
金光 禎寛 名古屋市立大学, 医薬学総合研究院(医学), 助教 (20765268)
竹村 昌也 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (30378707)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性咳嗽 / 咳喘息 / GERD / バイオマーカー / 胃食道逆流症 / 副鼻腔気管支症候群 / 感染後咳嗽 / 内科 / アレルギー・ぜんそく |
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| Outline of Final Research Achievements |
Analysis of 312 patients with prolonged or chronic cough revealed a very high prevalence of GERD (46%) as compared with previous studies in Japan, and its relevance to the treatment refractoriness of cough（Kanemitsu et al. Allergol Int 2019）. FSSG questionnaire was useful in the diagnosis of these GERD patients（Kurokawa et al. J Asthma 2021）. Capsaicin cough reflex sensitivity was significantly associated with the clinical features of severe asthma suggested by ATS/ERS in consecutive 157 patients with asthma（Kanemitsu et al. Am J Respir Crit Care Med 2020）. Involvement of GERD in asthma pathophysiology was clarified with a use of HARQ questionnaire（Kurokawa et al. Allergol Int 2022）.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性咳嗽はQOL低下や就労困難も来す重要な臨床的課題であるが、専門医も対応に難渋する。「咳嗽に関するガイドライン」に拠ると病歴、身体所見、臨床検査に基づく「治療前診断」（疑い診断）に対して特異的治療を行い、奏功したら「治療後診断」（確定診断）とするが、実際には信頼性の高い治療前診断手段は少なく、手探りで薬剤を選択し、効果を試している現状がある。
今回明らかにした胃食道逆流症の重症化への寄与、診断における質問票の有用性は非専門医も含めた日常診療に資するところが大きい。また咳受容体感受性亢進の寄与は慢性咳嗽のみならず喘息の重症化機序解明と新規治療の開発に有益な知見をもたらすものである。
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Report
(6 results)
Research Products
(73 results)
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[Journal Article] Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.2019
Author(s)
Cui S, Ito I, Nakaji H, Iwata T, Matsumoto H, Oguma T, Tajiri T, Nagasaki T, Kanemitsu Y, Izuhara H, Mishima M, Niimi A.
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Journal Title
Respir Physiol Neurobiol.
Volume: 263
Pages: 1-8
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Clinical impact of gastroesophageal reflux disease in patients with subacute/chronic cough.2019
Author(s)
Kanemitsu Y Kurokawa R, Takeda N, Takemura M, Fukumitsu K, Asano T, Yap MSJ, Suzuki M, Fukuda S, Ohkubo H, Maeno K, Ito Y, Oguri T, Niimi A.
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tiotropium Attenuates Refractory Cough and Capsaicin Cough Reflex Sensitivity in Patients with Asthma.2018
Author(s)
Fukumitsu K, Kanemitsu Y, Asano T, Takeda N, Ichikawa H, Yap JMG, Fukuda S, Uemura T, Takakuwa O, Ohkubo H, Maeno K, Ito Y, Oguri T, Nakamura A, Takemura M, Niimi A
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Journal Title
J Allergy Clin Immunol Pract
Volume: 印刷中
Issue: 5
Pages: 613-620
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies.2017
Author(s)
Sonnappa S, McQueen B, Postma DS, Martin RJ, Roche N, Grigg J, Guilbert T, Gouder C, Pizzichini E, Niimi A, Phipatanakul W, Chisholm A, Dandurand RJ, Kaplan A, Israel E, Papi A, van Aalderen WMC, Usmani OS, Price DB.
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Journal Title
J Allergy Clin Immunol Pract
Volume: 印刷中
Issue: 3
Pages: 907-915.e7
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Serum periostin as a useful biomarker of comorbid chronic rhinosinusitis in patients with asthma2017
Author(s)
Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuk Fukumitsu e, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, and Akio Niimi
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Journal Title
Annals of the American Thoracic Society
Volume: 印刷中
Issue: 5
Pages: 667-675
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 最新呼吸器内科・外科学2019
Author(s)
新実彰男、編集伊達 洋至、平井 豊博
Total Pages
902
Publisher
メディカルレビュー社
ISBN
9784779223150
Related Report
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[Book] 今日の治療指針2017
Author(s)
新実彰男
Total Pages
1999
Publisher
医学書院
ISBN
9784260028080
Related Report
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[Book] 私の治療2017
Author(s)
新実彰男
Total Pages
1734
Publisher
日本医事新報社
ISBN
9784784946501
Related Report
