| Project/Area Number |
17K09725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
垣見 和宏 東京大学, 医学部附属病院, 特任教授 (80273358)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 慢性腎臓病 / 免疫チェックポイント機構 / 免疫チェックポイント / 人工透析学 / 免疫不全 |
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| Outline of Final Research Achievements |
Blood samples were collected and stored for 40 hemodialysis patients, 2 renal cancer patients, and 2 bladder cancer patients, and a QOL survey was conducted from 38 hemodialysis patients.
In the QOL survey, KDQOL-SF was used to compare the renal disease-specific scale and the comprehensive scale (SF-36) for 9 analyzable hemodialysis-introduced patients and 17 patients over 1 year after hemodialysis induction. With a renal disease-specific scale of 4 items and a comprehensive scale of 5 items, the average value of item scores was significantly higher in patients who had been on dialysis for more than 1 year after dialysis induction.
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| Academic Significance and Societal Importance of the Research Achievements |
QOL調査の結果から、血液透析導入となる保存期腎不全の状態よりも、血液透析導入1年後の患者でQOLが低下していることが示唆されたため、血液透析導入後も腎不全の持続によりQOLの低下が進行することが推定された。腎代替療法として9割以上で血液透析が選択される日本の治療において、QOLをいかに維持するかを考慮する必要がある。
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