| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The aim of this study is to identify islet antigen-specific T cell responses in the three subtypes of type 1 diabetes (T1D); acute onset (AT1D), slowly progressive (SP1D), and fulminant T1D (FT1D); and to induce the responsible antigen-specific regulatory T cells. We found that islet antigen-specific Th1 responses were up-regulated in AT1D and FT1D, and the specific Tr1 cell responses were diminished in FT1D. Furthermore, FT1D displayed the highest frequencies of islet antigen-specific CD8 T cells among the three subtypes of T1D. We are currently trying the induction of the antigen-specific regulatory T cells by using autologous dendritic cells that were differentiated from monocyte by using cytokines and educated with the responsible antigen peptides.
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