| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The number of patients with allergic diseases is now increasing. Th2 cytokines are known to play essential roles in the development of allergic immune responses. In the current study, we investigated the roles of the secretion-regulating protein Rab27 in Th2 cytokine signaling, and found that Rab27 regulates many pathways related to Th2 cytokine signal transduction. Our results imply that Rab27 functions as a master regulator in allergic immune responses.
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