| Project/Area Number |
17K10143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
香美 祥二 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (00224337)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | レニン / 進行性腎炎 / Wnt / アンジオテンシン / （プロ）レニン受容体 / 糸球体腎炎 / 循環器・高血圧 |
|---|
| Outline of Final Research Achievements |
We investigated the novel mechanism of glomerular injury via (pro)renin receptor in renin-angiotensin system activation. We found that the expression levels of (pro)renin receptor and Wnt signal in glomeruli are elevated during the course of rat progressive nephritis model. In addition, cultured mesangial cells showed the increased inflammatory cytokine through (pro)renin receptor with Wnt signaling. Those results suggest that the focus on the mechanism in (pro)renin receptor would provide the effective therapeutic strategy in progression of glomerulonephritis.
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| Academic Significance and Societal Importance of the Research Achievements |
研究成果は腎炎が進展する新しい機序を解明したものであり、これらの研究成果を元に従来にないより効果的な治療法が開発されれば腎炎による腎機能悪化を防ぐことができる。人工透析や腎移植に進行する患者に健康な生活をしてもらうことにより医療費を抑制するとともに社会貢献にもつながると期待できる。
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