Development of the novel therapy for psoriasis

• Project/Area Number: 17K10224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: Matsuzaki Yasushi 弘前大学, 医学部附属病院, 講師 (50322946)
• Co-Investigator(Kenkyū-buntansha): 澤村 大輔 弘前大学, 医学研究科, 教授 (60196334)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 乾癬 / 間葉系幹細胞 / 表皮水疱症 / 間葉系細胞 / 線維芽細胞 / 免疫学

Outline of Final Research Achievements

ASCs inhibit the production of Th17-associated cytokines, such as IL-17A and TNF-α, and minimize the psoriatic skin changes induced by IMQ. The administration of ASCs inhibits systemic IMQ-induced inflammation. In this study, we have proven the potential clinical application of allogeneic or autogenic ASCs for the treatment of psoriasis through a process that differs considerably from existing biological therapies.

Academic Significance and Societal Importance of the Research Achievements

間葉系幹細胞により乾癬様皮疹の改善を確認できた。間葉系幹細胞の持つ炎症部位に優先的に集まるホーミング効果、その集まった局所で生じる免疫抑制効果に焦点を当て乾癬治療に応用する研究は国内外になく、学術的意義は大きい研究である。患者自身の細胞である間葉系幹細胞を用いるので大きな副作用もなく、実用されれば乾癬の治療法の一つとなり、患者にとって有益である。

Research Products

• [Journal Article] Partial spontaneous regression of pediatric large fibroblastic connective tissue nevus (2020)
  • Author(s): Takahashi Mika、Matsuzaki Yasushi、Nakano Hajime、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 1 Issue: 6 Pages: 12-12
  • DOI: 10.1111/1346-8138.15320
  • Peer Reviewed / Open Access
• [Journal Article] Dipeptidyl peptidase‐4 inhibitor‐associated anti‐laminin‐γ1 (p200) pemphigoid in a patient with psoriasis vulgaris (2019)
  • Author(s): Minakawa Satoko、Matsuzaki Yasushi、Hashimoto Takashi、Ishii Norito、Nishie Wataru、Kayaba Hiroyuki、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 1
  • DOI: 10.1111/1346-8138.15126
  • Peer Reviewed / Open Access
• [Journal Article] Pediculus humanus capitis: Pyrethroid resistance and utility of scanning electron microscopy (2019)
  • Author(s): Minakawa Satoko、Matsuzaki Yasushi、Yamaguchi Sayaka、Takahashi Kenzo、Kayaba Hiroyuki、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 11
  • DOI: 10.1111/1346-8138.15009
  • Peer Reviewed / Open Access
• [Journal Article] Two cases of ichthyosis and their EPR analyses of stratum corneum (2019)
  • Author(s): S. Minakawa, Y. Mastuzaki, K. Nakagawa, T. Kaneko, E. Akasaka, D. Sawamura
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: - Issue: 3 Pages: 1-3
  • DOI: 10.1002/cia2.12057
  • Peer Reviewed / Open Access
• [Journal Article] The first Japanese case of familial porphyria cutanea tarda diagnosed by a UROD mutation (2019)
  • Author(s): Matsui Akinobu、Akasaka Eijiro、Rokunohe Daiki、Matsuzaki Yasushi、Sawamura Daisuke、Nakano Hajime
  • Journal Title: Journal of Dermatological Science Volume: 93 Issue: 1 Pages: 65-67
  • DOI: 10.1016/j.jdermsci.2018.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Pyoderma gangrenosum triggered by switching from adalimumab to secukinumab (2018)
  • Author(s): Jin Kayo、Matsuzaki Yasushi、Akasaka Eijiro、Nakano Hajime、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 3
  • DOI: 10.1111/1346-8138.14611
  • Peer Reviewed / Open Access
• [Journal Article] Spontaneous remission of methotrexate-associated lymphoproliferative disorder with Epstein-Barr virus type II latency. (2018)
  • Author(s): Matsuzaki Y, Minakawa S, Sagara C, Takiyoshi N, Nakano H, Sawamura D.
  • Journal Title: Eur J Dermatol Volume: 23 Pages: 693-694
  • Peer Reviewed
• [Journal Article] Cutaneous collagenous vasculopathy induced by the vascular endothelial growth factor receptor inhibitor axitinib (2018)
  • Author(s): Matsuzaki Yasushi、Takahashi Mika、Minakawa Satoko、Jin Kayo、Nakano Hajime、Sawamura Daisuke
  • Journal Title: International Journal of Dermatology Volume: 57 Issue: 12
  • DOI: 10.1111/ijd.14243
  • Peer Reviewed / Open Access
• [Journal Article] Thymus and activation-regulated chemokine elevation and lymphocytosis in a case of diffuse large B-cell lymphoma (2018)
  • Author(s): Minakawa Satoko、Nakajima Koji、Kaneko Takahide、Matsuzaki Yasushi、Takahata Takenori、Itabashi Chieko、Kayaba Hiroyuki、Sawamura Daisuke
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: 1 Issue: 1 Pages: 41-43
  • DOI: 10.1002/cia2.12005
  • Peer Reviewed / Open Access
• [Journal Article] Irreversible bilateral cyanosis of the hands caused by hypothenar hammer syndrome with systemic sclerosis (2018)
  • Author(s): Jin K, Matsuzaki Y, Akasaka E, Fukui T, Sagara C, Nakano H, Sawamura D
  • Journal Title: Eur J Dermatol Volume: 28 Issue: 4 Pages: 525-526
  • DOI: 10.1684/ejd.2018.3311
  • Peer Reviewed
• [Journal Article] Tuberculous granuloma developed 9 years after bacillus Calmette-Gu?rin vaccination in a patient with immunodeficiency (2018)
  • Author(s): Minakawa Satoko、Matsuzaki Yasushi、Terui Kiminori、Kayaba Hiroyuki、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 11
  • DOI: 10.1111/1346-8138.14468
  • Peer Reviewed / Open Access
• [Journal Article] Effcts of halothane anesthesia on electrocardiogram parameters. (2017)
  • Author(s): Nozaki S, Ogata Y, Yonekura M, Han C, Niwa H, Kushikata T, Hirota K, Matsuzaki Y, Tomita H, Imaizumi T, Itagaki S, Sawamura D, Murakami M.
  • Journal Title: Hirosaki Med J Volume: 67 Pages: 129-135
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus ?in?Japan, particularly in Ishigaki, Okinawa (2017)
  • Author(s): Takadama S, Nakaminami H, Aoki S, Akashi M, Wajima T, Ikeda M, Mochida A, Shimoe F, Kimura K, Matsuzaki Y, Sawamura D, Inaba Y, Oishi T, Nemoto O, Baba N, Noguchi N
  • Journal Title: J Infect Chemother. Volume: 23 Issue: 11 Pages: 800-803
  • DOI: 10.1016/j.jiac.2017.04.016
  • Peer Reviewed / Open Access
• [Journal Article] Successful treatment of Kyrle disease with narrowband ultraviolet B (2017)
  • Author(s): Matsuzaki Y, Yokoyama S, Rokunohe A, Minakawa S, Nakano H, Sawamura D.
  • Journal Title: J Dermatol Volume: 印刷中 Issue: 6 Pages: 721-722
  • DOI: 10.1111/1346-8138.13525
  • Peer Reviewed / Open Access
• [Journal Article] Psoriasis Area and Severity Index is closely related to serum C-reactive protein level and neutrophil to lymphocyte ratio in Japanese patients (2017)
  • Author(s): Minakawa Satoko、Kaneko Takahide、Matsuzaki Yasushi、Yamada Masahiro、Kayaba Hiroyuki、Sawamura Daisuke
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 10
  • DOI: 10.1111/1346-8138.13942
  • Peer Reviewed / Open Access
• [Journal Article] Successful treatment of low-dose methotrexate in combination with systemic steroids for juvenile multiple and symmetrical circumscribed morphea (2017)
  • Author(s): Jin K、Matsuzaki Y、Akasaka E、Korekawa A、Nakano H、Sawamura D
  • Journal Title: The Journal of Dermatology Volume: 44 Issue: 10
  • DOI: 10.1111/1346-8138.13943
  • Peer Reviewed / Open Access
• [Journal Article] Incontinentia pigmenti in a male (XY) infant with long-term follow up over 8 years (2017)
  • Author(s): Matsuzaki Y, Rokunohe A, Minakawa S, Nomura K, Nakano H, Ito E, Sawamura D
  • Journal Title: The Journal of Dermatology Volume: 45 Issue: 1 Pages: 100-103
  • DOI: 10.1111/1346-8138.14002
  • Peer Reviewed / Open Access
• [Journal Article] Modulation of Stimulator of Interferon Genes (STING) Expression by Interferon-γ in Human Keratinocytes (2017)
  • Author(s): Nishikawa Y, Matsuzaki Y, Kimura K, Rokunohe A, Nakano H, Sawamura D
  • Journal Title: Biochemical Genetics Volume: 56 Issue: 1-2 Pages: 93-102
  • DOI: 10.1007/s10528-017-9832-7
  • Peer Reviewed / Open Access
• [Journal Article] A randomized double-blind trial of intravenous (2016)
  • Author(s): Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, et al.
  • Journal Title: J Dermatol Sci Volume: 85（2） Issue: 2 Pages: 77-84
  • DOI: 10.1016/j.jdermsci.2016.11.003
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of ultrasonography in the diagnosis of ischaemic fasciitis. (2016)
  • Author(s): Kaneko T, Rokunohe D, Takiyoshi N, Minakawa S, Nakano H, Sawamura D
  • Journal Title: Clin Exp Dermatol Volume: 41 Issue: 6 Pages: 502-505
  • DOI: 10.1111/ijd.12380
  • Peer Reviewed / Open Access
• [Presentation] Dipeptidyl peptidase-Ⅳ阻害薬関連水疱性類天疱瘡と鑑別を要した抗ラミニンγ1類天疱瘡の1例 (2020)
  • Author(s): 皆川智子，松﨑康司，中野 創，澤村大輔，萱場広之，西江 渉，石井文人，橋本 隆
  • Organizer: 第41回水疱症研究会
• [Presentation] アプレミラストで満足度が改善した乾癬性関節炎の1例 (2019)
  • Author(s): 皆川智子、松﨑康司、中野 創、澤村大輔、中澤 満、萱場広之
  • Organizer: 日本皮膚科学会青森地方会第388回例会
• [Presentation] 皮膚クリプトコッカス症の1例 (2019)
  • Author(s): 松井彰伸、六戸大樹、松﨑康司、中野 創、澤村大輔
  • Organizer: 日本皮膚科学会青森地方会第388回例会
• [Presentation] Autoimmune reaction targeted for the C-terminal domain of BP230 induces experimental bullous pemphigoid in mice (2019)
  • Author(s): Yasushi Matsuzaki, Eiko Makita, Tomohisa Fukui, Hajime Nakano, Daisuke Sawamura
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Int'l Joint Research
• [Presentation] 尋常性乾癬に合併した抗ラミニンγ 1(p200)類天疱瘡の1例 (2019)
  • Author(s): 皆川智子、松崎康司、中野 創、澤村大輔、萱場広之、西江 渉、石井文人、橋本 隆
  • Organizer: 日本皮膚科学会青森地方会第387回例会
• [Presentation] アタマジラミ症の1例 (2019)
  • Author(s): 皆川智子、松﨑康司、中野 創、澤村大輔、山口さやか、高橋健造
  • Organizer: 第46回皮膚かたち研究学会学術大会
• [Presentation] 皮膚における類天疱瘡抗原1の機能的役割の解析 (2018)
  • Author(s): 松﨑康司、牧田瑛子、福井智久、中野 創、澤村大輔
  • Organizer: 第25回分子皮膚科学フォーラム
• [Presentation] 当科通院中の乾癬患者におけるPASIとDLQIに影響を与える因子の検討. (2018)
  • Author(s): 皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、山邊佑樹、齋藤紀先、 萱場広之
  • Organizer: 日本皮膚科学会東北六県合同地方会学術大会第382回例会
• [Presentation] 膠原病で見られる皮膚症状 (2018)
  • Author(s): 松﨑康司
  • Organizer: 第29回青森県リウマチ懇話会
  • Invited
• [Presentation] 遺伝性角化異常症2例のスピンラベル法による角質解析 (2018)
  • Author(s): 皆川智子、松﨑康司、赤坂英二郎、金子高英、今 淳、中野 創、澤村大輔、中川公一、野村和夫、松木哲文
  • Organizer: 日本皮膚科学会青森地方会第383回例会
• [Presentation] DPP-4阻害薬内服中に発症した水疱性類天疱瘡の1例 (2018)
  • Author(s): 皆川智子、松崎康司、中野 創、澤村大輔、橋本 隆、 石井文人、西江 渉
  • Organizer: 日本皮膚科学会青森地方会第385回例会
• [Presentation] ミルメシア様外観を呈した踵部悪性黒色腫 (2018)
  • Author(s): 原 憲司、会津隆幸、滝吉典子、金子高英、松﨑康司、中野 創、澤村大輔、北村英夫
  • Organizer: 日本皮膚科学会青森地方会第385回例会
• [Presentation] BCGによる皮膚結核性肉芽腫の1例 (2017)
  • Author(s): 皆川智子、松﨑康司、中野 創、澤村大輔、照井君典、萱場広之
  • Organizer: 青森地方会第379回例会
• [Presentation] 皮膚科新薬の効果と最近経験した興味深い症例 (2017)
  • Author(s): 松﨑康司
  • Organizer: 第124回弘前皮膚科専門医会
• [Presentation] 当科でアプレミラストを導入した9例の検討. (2017)
  • Author(s): 皆川智子、松﨑康司、金子高英、中野 創、澤村大輔、齋藤紀先、萱場広之
  • Organizer: 青森地方会第380回例会
• [Presentation] 当科通院中の乾癬患者におけるPASIスコアとDLQIの相関性についての検討 (2017)
  • Author(s): 皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、齋藤紀先、萱場広之
  • Organizer: 第32回日本乾癬学会学術大会
• [Presentation] 葉状魚鱗癬の1例 (2017)
  • Author(s): 皆川智子、金子高英、松﨑康司、中川公一、今 淳、中野 創、野村和夫、Bijan Ahvazi、Peter M.Steinert、澤村大輔
  • Organizer: 第44回皮膚かたち研究学会学術大会