Quantification and biological backgrounds of depressive mixed state
| Project/Area Number |
17K10311
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
Kondo Tsuyoshi 琉球大学, 医学(系)研究科(研究院), 教授 (40215455)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
三原 一雄 琉球大学, 医学(系)研究科(研究院), 客員研究員 (30302029)
甲田 宗良 琉球大学, 医学(系)研究科(研究院), 助教 (50736189)
新里 輔鷹 琉球大学, 医学(系)研究科(研究院), 助教 (20838057)
|
|---|
| Project Period (FY) |
2017-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 抑うつ性混合状態 / 定量的評価 / 破壊的な感情/行動 / 重症度 / 双極性 / 若年 / スクリーニング / 内発的な不安定さ / 脆弱な応答性 / うつ病エピソード / DMX-12 / 破壊的感情/行動 / 混合うつ病 / 混合性特徴 / DMX-5 / 探索的因子分析 / 脆弱な反応・応答性 / 神経生理 / 神経免疫 |
|---|
| Outline of Final Research Achievements |
Depressive mixed state (DMX) in patients with major depressive episode was examined using the 12-item quantification scale for DMX (DMX-12) developed by us. Main DMX symptoms were hypersensitivity, racing/crowded thought, distractibility, overreaction, and inner tension. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX, especially with disruptive emotion/behavior symptoms.
Selected 8 symptoms from the DMX-12 may be helpful in screening of DMX with considerable severity since it well differentiates individuals with mixed depression or mixed features during major depressive episode from non-mixed patients, with the same cut-off and excellent sensitivity/negative predictive value.
|
| Academic Significance and Societal Importance of the Research Achievements |
過少診断されやすい抑うつ性混合状態が、我々が開発したDMX-12により重症度が数値化され、一定の重症度を持った抑うつ性混合状態のスクリーニングが可能となった点で、臨床的な診断意義は大きい。
本スクリーニングの使用により、陰性例では十分な抗うつ薬治療を安全に進め、陽性例では抑うつ性混合状態の診断的な面接に進み、抗うつ薬を回避した薬物選択（気分安定薬や非定型抗精神病薬の導入）を合理的に選択することが可能となり、治療の質の向上や薬効判定にも寄与する点で社会的意義も大きい。
|
Report
(5 results)
Research Products
(34 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.2017
Author(s)
Takamatsu G, Katagiri C, Tomoyuki T, Shimizu-Okabe C, Nakamura W, Nakamura-Higa M, Hayakawa T, Wakabayashi S, Kondo T, Takayama C, Matsushita M.
-
Journal Title
Biochem Biophys Res Commun.
Volume: 482
Issue: 4
Pages: 1327-1333
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
