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Quantification and biological backgrounds of depressive mixed state

Research Project

Project/Area Number 17K10311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Kondo Tsuyoshi  琉球大学, 医学(系)研究科(研究院), 教授 (40215455)

Co-Investigator(Kenkyū-buntansha) 三原 一雄  琉球大学, 医学(系)研究科(研究院), 客員研究員 (30302029)
甲田 宗良  琉球大学, 医学(系)研究科(研究院), 助教 (50736189)
新里 輔鷹  琉球大学, 医学(系)研究科(研究院), 助教 (20838057)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords抑うつ性混合状態 / 定量的評価 / 破壊的な感情/行動 / 重症度 / 双極性 / 若年 / スクリーニング / 内発的な不安定さ / 脆弱な応答性 / うつ病エピソード / DMX-12 / 破壊的感情/行動 / 混合うつ病 / 混合性特徴 / DMX-5 / 探索的因子分析 / 脆弱な反応・応答性 / 神経生理 / 神経免疫
Outline of Final Research Achievements

Depressive mixed state (DMX) in patients with major depressive episode was examined using the 12-item quantification scale for DMX (DMX-12) developed by us. Main DMX symptoms were hypersensitivity, racing/crowded thought, distractibility, overreaction, and inner tension. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX, especially with disruptive emotion/behavior symptoms.
Selected 8 symptoms from the DMX-12 may be helpful in screening of DMX with considerable severity since it well differentiates individuals with mixed depression or mixed features during major depressive episode from non-mixed patients, with the same cut-off and excellent sensitivity/negative predictive value.

Academic Significance and Societal Importance of the Research Achievements

過少診断されやすい抑うつ性混合状態が、我々が開発したDMX-12により重症度が数値化され、一定の重症度を持った抑うつ性混合状態のスクリーニングが可能となった点で、臨床的な診断意義は大きい。
本スクリーニングの使用により、陰性例では十分な抗うつ薬治療を安全に進め、陽性例では抑うつ性混合状態の診断的な面接に進み、抗うつ薬を回避した薬物選択(気分安定薬や非定型抗精神病薬の導入)を合理的に選択することが可能となり、治療の質の向上や薬効判定にも寄与する点で社会的意義も大きい。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (34 results)

All 2021 2020 2019 2018 2017 2016

All Journal Article (16 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 13 results,  Open Access: 7 results) Presentation (16 results) Book (2 results)

  • [Journal Article] The 12-Item Self-Rating Questionnaire for Depressive Mixed State (DMX-12) for Screening of Mixed Depression and Mixed Features2020

    • Author(s)
      Shinzato Hotaka、Zamami Yu、Kondo Tsuyoshi
    • Journal Title

      Brain Sciences

      Volume: 10 Issue: 10 Pages: 678-678

    • DOI

      10.3390/brainsci10100678

    • NAID

      120006892755

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A High Plasma Lamotrigine Concentration at Week 2 as a Risk Factor for Lamotrigine-Related Rash.2020

    • Author(s)
      Suzuki Takeshi, Mihara Kazuo, Nagai Goyo, Kagawa Shoko, Nakamura Akifumi, Nemoto Kenji, Kondo Tsuyoshi
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: - Issue: 4 Pages: 631-635

    • DOI

      10.1097/ftd.0000000000000733

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Psychopathology and clinical outcome of first-visit outpatients under 20 years old exhibiting a psychotic state2020

    • Author(s)
      Takao Ishibashi、Hotaka Shinzato、Yu Zamami、Morihiro Shimabukuro、Tsuyoshi Kondo
    • Journal Title

      Ryukyu Medical Journal

      Volume: 1~4 Pages: 29-40

    • NAID

      120007170392

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Public recognition of and attitudes toward suicidality: a study of various factors affecting gatekeeper capability2020

    • Author(s)
      Teizo Kuba、Yuzuru Nakamoto、Munenaga Koda、Hiroshi Fukuhara、Satoshi Michishita、Takashi Yakushi、Osamu Tanaka、Tsuyoshi Kondo
    • Journal Title

      Ryukyu Medical Journal

      Volume: 1~4 Pages: 1-14

    • NAID

      120007170395

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 初診時に精神病症状を呈する20歳未満の患者の特徴2020

    • Author(s)
      近藤毅
    • Journal Title

      児童青年精神医学とその近接領域

      Volume: 61 Pages: 215-220

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Development of the 12-item questionnaire for quantitative assessment of depressive mixed state (DMX-12).2019

    • Author(s)
      Shinzato Hotaka, Koda Munenaga, Nakamura Akifumi, Kondo Tsuyoshi
    • Journal Title

      Neuropsychiatry Disease and Treatment

      Volume: 15 Pages: 1983-1991

    • DOI

      10.2147/ndt.s215478

    • NAID

      120006768441

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] うつ病の寛解・回復後の治療:再発予防に向けた薬物維持療法と減薬・休薬の基準2019

    • Author(s)
      近藤毅
    • Journal Title

      臨床精神薬理

      Volume: 22 Pages: 783-790

    • Related Report
      2019 Research-status Report
  • [Journal Article] Relationship Between UGT1A4 and UGT2B7 Polymorphisms and the Steady-State Plasma Concentrations of Lamotrigine in Patients With Treatment-Resistant Depressive Disorder Receiving Lamotrigine as Augmentation Therapy2019

    • Author(s)
      Suzuki Takeshi、Mihara Kazuo、Nagai Goyo、Kagawa Shoko、Nakamura Akifumi、Nemoto Kenji、Kondo Tsuyoshi
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 41 Issue: 1 Pages: 86-90

    • DOI

      10.1097/ftd.0000000000000577

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of attitudes towards ambiguity on subclinical depression and anxiety in healthy individuals2019

    • Author(s)
      Enoki Hiroyuki、Koda Munenaga、Nishimura Sayako、Kondo Tsuyoshi
    • Journal Title

      Health Psychology Open

      Volume: 6 Issue: 1 Pages: 1-7

    • DOI

      10.1177/2055102919840619

    • NAID

      120006768440

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] “抑うつ性混合状態”をどう見極めるか2018

    • Author(s)
      近藤毅
    • Journal Title

      九州神経精神医学

      Volume: 64 Pages: 30-32

    • Related Report
      2018 Research-status Report
  • [Journal Article] A Partial Response at Week 4 Can Predict Subsequent Outcome during Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder: A Preliminary Study2018

    • Author(s)
      Nagai Goyo、Mihara Kazuo、Kagawa Shoko、Nakamura Akifumi、Suzuki Takeshi、Nemoto Kenji、Kondo Tsuyoshi
    • Journal Title

      Neuropsychobiology

      Volume: 76 Issue: 4 Pages: 187-192

    • DOI

      10.1159/000489967

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Both serum brain-derived neurotrophic factor and interleukin-6 levels are not associated with therapeutic response to lamotrigine augmentation therapy in treatment-resistant depressive disorder2017

    • Author(s)
      Kagawa S, Mihara K, Suzuki T, Nagai G, Nakamura A, Nemoto K, Kondo T
    • Journal Title

      Neuropsychobiology

      Volume: 75 Issue: 3 Pages: 145-150

    • DOI

      10.1159/000484665

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Usefulness of an educational lecture focusing on improvement in public awareness of and attitudes toward depression and its treatments2017

    • Author(s)
      Yakushi T, Kuba T, Nakamoto Y, Fukuhara H, Koda M, Tanaka O, Kondo T
    • Journal Title

      BMC Health Service Research

      Volume: 17 Issue: 1

    • DOI

      10.1186/s12913-017-2071-0

    • NAID

      120006768439

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.2017

    • Author(s)
      Takamatsu G, Katagiri C, Tomoyuki T, Shimizu-Okabe C, Nakamura W, Nakamura-Higa M, Hayakawa T, Wakabayashi S, Kondo T, Takayama C, Matsushita M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 482 Issue: 4 Pages: 1327-1333

    • DOI

      10.1016/j.bbrc.2016.12.036

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Attitudes towards ambiguity in Japanese healthy volunteers2017

    • Author(s)
      Enoki H, Koda M, Saito A, Nishimura S, Kondo T
    • Journal Title

      Current Psychology

      Volume: 36 Issue: 4 Pages: 1-11

    • DOI

      10.1007/s12144-017-9569-9

    • NAID

      120006772190

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of an optimal dose of aripiprazole in the treatment of schizophrenia from plasma concentrations of aripiprazole plus its active metabolite dehydroaripiprazole at week 1.2016

    • Author(s)
      Nagai G, Mihara K, Nakamura A, Nemoto K, Kagawa S, Suzuki T, Kondo T
    • Journal Title

      Therapeutic Drug Monitoring

      Volume: 39 Issue: 1 Pages: 62-65

    • DOI

      10.1097/ftd.0000000000000358

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 抑うつ性混合状態と自閉スペクトラム症との関連2019

    • Author(s)
      新里輔鷹、栗原雄大、石橋孝勇、甲田宗良、中村明文、近藤毅
    • Organizer
      日本精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 20歳未満の統合失調症関連障害の後方視的分析2019

    • Author(s)
      石橋孝勇、島袋盛洋、近藤毅
    • Organizer
      日本精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 栗原雄大、前上里泰史、新城架乃、石橋孝勇、新里輔鷹、甲田宗良、中井美紀、大鶴卓、近藤毅2019

    • Author(s)
      統合失調症認知機能評価尺度日本語版(BACS-J)を用いたアルコール依存症患者の認知機能の評価
    • Organizer
      日本精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難治性うつ病性障害に対するラモトリギン強化療法患者においてABCG2 C421Aがラモトリギン血漿濃度に与える影響2019

    • Author(s)
      鈴木毅、永井五洋、中村明文、香川祥子、根本健二、三原一雄、近藤毅
    • Organizer
      日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT1A4及びUGT2B7遺伝子多型との関連2019

    • Author(s)
      香川祥子、鈴木毅、永井五洋、中村明文、根本健二、三原一雄、近藤毅
    • Organizer
      日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とABCG2 C421A遺伝子多型との関連2019

    • Author(s)
      永井五洋、鈴木毅、香川祥子、中村明文、根本健二、三原一雄、近藤毅
    • Organizer
      日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Lamotrigineによる難治性うつ病性障害強化療法の治療反応性とAMPA受容体GRM2遺伝子多型との関連性について2019

    • Author(s)
      村明文、永井五洋、香川祥子、鈴木毅、根本健二、三原一雄、近藤毅
    • Organizer
      日本臨床精神神経薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 抑うつ性混合状態の定量評価に向けた自記式評価票(DMX-12)の開発2018

    • Author(s)
      新里輔鷹,栗原雄大,石橋孝勇,甲田宗良,榎木宏之,中村明文,近藤毅
    • Organizer
      第114回日本精神神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抑うつ性混合状態のカテゴリカル診断と自記式評価票(DMX-12)との関連2018

    • Author(s)
      新里輔鷹,栗原雄大,石橋孝勇,甲田宗良,榎木宏之,中村明文,近藤毅
    • Organizer
      第114回日本精神神経学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 治療2週目のlamotrigine血漿濃度高値がlamotrigineによる皮疹発現と関連する2018

    • Author(s)
      永井五洋,鈴木毅,香川祥子,中村明文,三原一雄,近藤毅
    • Organizer
      第28回日本臨床精神神経薬理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 難治性うつ病性障害に対するlamotrigine強化療法においてlamotrigine投与量予測に有用と考えられるnomogramの妥当性を検証する2018

    • Author(s)
      中村明文,永井五洋,香川祥子,鈴木毅,根本健二,三原一雄,近藤毅
    • Organizer
      第28回日本臨床精神神経薬理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 難治性うつ病性障害におけるラモトリギン強化療法の治療反応性とUGT1A4 142T>G遺伝子多型との関連2018

    • Author(s)
      香川祥子,鈴木毅,永井五洋,中村明文,根本健二,三原一雄,近藤毅
    • Organizer
      第28回日本臨床精神神経薬理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 統合失調症治療1週後のaripiprazoleと活性代謝産物血漿濃度から至適投与量を予測する2017

    • Author(s)
      中村明文、永井五洋、根本健二、香川祥子、鈴木毅、三原一雄、近藤毅
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 永井五洋、鈴木毅、香川祥子、中村明文、三原一雄、近藤毅2017

    • Author(s)
      Lamotrigineによる難治性うつ病性障害強化療法の治療反応性とABCB1遺伝子多型との関連性について
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 香川祥子、根本健二、鈴木毅、永井五洋、中村明文、三原一雄、近藤毅2017

    • Author(s)
      年次性うつ病性障害に対するラモトリギン強化療法において治療4週目での症状改善率による治療反応性の予測の可能性について
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 難治性うつ病性障害に対するラモトリギン強化療法患者においてUGT1A4 142T>GとUGT2B7 372A>G、-161C>Tがラモトリギン血漿濃度に与える影響2017

    • Author(s)
      鈴木毅、中村明文、香川祥子、永井五洋、根本健二、三原一雄、近藤毅
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Book] 専門医のための臨床精神神経薬理学テキスト2021

    • Author(s)
      日本臨床精神神経薬理学会専門医制度委員会、下田 和孝、古郡 規雄
    • Total Pages
      448
    • Publisher
      星和書店
    • ISBN
      9784791110742
    • Related Report
      2020 Annual Research Report
  • [Book] 精神科薬物療法に再チャレンジ2020

    • Author(s)
      日本臨床精神神経薬理学会、寺尾 岳
    • Total Pages
      272
    • Publisher
      星和書店
    • ISBN
      9784791110575
    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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