| Project/Area Number |
17K10314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Osone Akira 獨協医科大学, 医学部, 非常勤講師 (20194152)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ビタミンD / 軽度認知障害 / アルツハイマー病 / 二重盲検法 / 頭部血流検査 / 頭部MRI / 神経心理学的検査 / RCT / SPECT / 介入研究 / Conversion / Reversion / 頭部SPECT / Vitamin D / 脳神経疾患 / 薬剤反応性 / 老化 |
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| Outline of Final Research Achievements |
Forty patients with MCI were recruited fin the primary study and randomized, double-blind, placebo-controlled trial compering Vitamin D supplements (1000 IU/d) group with placebo group. The patients were investigated each 3-months for a year with a battery of neuropsychological tests comprising MMSE, ADAS-J cog, CDR, NPI, and FAB, along with magnetic resonance imaging, single-photon emission computed tomography at baseline and at one year later.
Vitamin D group (n = 17) showed improvement of right anterior cerebral artery flow (p =0.02) and right posterior insular part of right middle cerebral artery flow (p =0.04) compared with placebo group (n = 14), however, there was no significant improvement in terms of cognitive function or brain MRI imaging. Conclusion: Our results suggested positive effect of Vitamin D supplement for specific regional cerebral blood flow; improvement of executive functioning or somatosensory information.
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| Academic Significance and Societal Importance of the Research Achievements |
二重盲検法によりビタミンDの認知機能低下抑制に関する有効性を実証した研究である。すなわち，ビタミンDを投与した軽度認知障害患者がプラセボを投与した群と比較し，特定部位の脳血流の改善を示す可能性を示唆した研究である。
一般に高齢者では血中のビタミンD濃度が低下していることが知られており，今後は安全・安価で入手可能なビタミンDを摂取することにより認知機能低下抑制が図られる可能性を示した点に社会的な意義がある。
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