Analysis of anal function after adipose-derived stem cell transplantation
| Project/Area Number |
17K10638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江口 晋 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80404218)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 肛門括約筋 / 脂肪幹細胞 / 横紋筋再生 / 肛門機能 / 肛門内圧 / 肛門機能再生 / 電気刺激 / 再生医療 / 肛門機能不全 |
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| Outline of Final Research Achievements |
We attempted to improve anal function through adipose-derived stem cell transplantation ｂｙ using anal insufficiency rats. Although anal function improved with the transplantation of adipose-derived stem cells, we were unable to demonstrate histologically the regeneration of muscle tissue.
Considering the difficulty of improving anal function through adipose-derived stem cell transplantation in humans, we attempted to improve anal function through anal sphincter stimulation. In rats, improvement in anal function was observed due to muscle hypertrophy, but this has not yet been applied to humans so far.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の本来の研究の目的は、直腸癌患者に対する肛門温存手術後に生じる患者の肛門機能低下を改善させ、患者のQOLを向上させることにあった。肛門温存手術では、自然肛門が温存される反面、頻便や便の漏出などの肛門機能の低下がしばしば生じる。直腸を再生させる研究は困難と考え、肛門括約筋の再生を試みた。脂肪幹細胞は現在、実用するまでに進歩しているが、クローン病の痔瘻手術の再発予防などへの仕様に限られ、肛門機能の改善に関係する横紋筋の再生には至っていない。我々は、残存肛門括約筋を増強させる方向性に転換し、この方法であれば臨床応用も現実味を帯びてきていると感じている。
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Report
(7 results)
Research Products
(31 results)
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[Journal Article] Clinical impact of laparoscopic surgery and adhesion prevention material for prevention of small bowel obstruction.2022
Author(s)
Yamada T, Hirata K, Ichikawa D, Ikeda M, Fujita F, Eto K, Yukawa N, Kojima Y, Matsuda A, Shimoyama R, Ochiai H, Kumamoto K, Takayama Y, Komono A, Sonoda H, Ohta R, Yokoyama Y, Yoshida H, Kaibori M, Takemasa I.
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Journal Title
Ann Gastroenterol Surg
Volume: 6
Pages: 651-657
Related Report
Peer Reviewed
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[Journal Article] Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study.2022
Author(s)
Fujiyoshi K, Sudo T, Fujita F, Chino A, Akagi K, Takao A, Yamada M, Tanakaya K, Ishida H, Komori K, Ishihara S, Miguchi M, Hirata K, Miyakura Y, Ishikawa T, Yamaguchi T, Tomita N, Ajioka Y, Sugihara K.
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Journal Title
Int J Clin Oncol
Volume: 27
Pages: 1051-1059
Related Report
Peer Reviewed
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[Journal Article] Significance of serum palmitoleic acid levels in inflammatory bowel disease.2021
Author(s)
Akazawa Y, Morisaki T, Fukuda H, Norimatsu K, Shiota J, Hashiguchi K, Tabuchi M, Kitayama M, Matsushima K, Yamaguchi N, Kondo H, Fujita F, Takeshita H, Nakao K, Takeshima F.
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Journal Title
Scientific Report
Volume: 11
Issue: 1
Pages: 16260-16260
DOI
NAID
Related Report
Peer Reviewed / Open Access
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