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The role of inflammation and fibrosis through the malignant process in lung cancer

Research Project

Project/Area Number 17K10793
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionNational Hospital Organization, Kyushu Medical Center (Clinical Institute) (2018-2019)
Kyushu University (2017)

Principal Investigator

Fumihiro Shoji  独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 呼吸器外科医師 (90444851)

Co-Investigator(Kenkyū-buntansha) 豊川 剛二  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 呼吸器腫瘍科医師 (30627261)
岡本 龍郎  大分大学, 医学部, 准教授 (80568626)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 線維性サイトカイン / 炎症性サイトカイン / 炎症性バイオマーカー / 悪性度獲得 / 予後因子 / 間質性肺炎 / 線維化 / 悪性度 / 予後 / 非小細胞肺癌 / 間質性肺炎合併 / 線維化サイトカイン / 間質性肺炎合併肺癌 / 繊維化サイトカイン / 抗炎症 / 抗線維化
Outline of Final Research Achievements

Result①:In lung cancer patients without interstitial pneumonia, IL-6 expression in non-cancerous tissue was high,although VEGF expression in cancerous tissue was high. On the other hand, in lung cancer patients with interstitial pneumonia, IL-6 expression in non-cancerous tissue was also high,although IL-1beta, VEGF and FGF expressions were high in cancerous tissue, respectively. FGF expression in both cancerous and non-cancerous tissue were high in lung cancer patients without interstitial pneumonia. Result②: Preoperative high MLR levels were significantly associated with patient sex, smoking status, and postoperative recurrence. Only preoperative MLR levels were identified as an independent predictor of shorter RFS. Five-year RFS rates in patients with preoperatively high MLR levels were significantly lower than in those with low MLR levels. In subgroup analysis, the high MLR level subgroup with tumors >2 cm had significantly shorter RFS than other subgroups.

Academic Significance and Societal Importance of the Research Achievements

研究①:炎症性・線維性サイトカインの中で、Fibroblast growth factor (FGF)は間質性肺炎合併肺癌及び非合併肺癌における悪性度獲得メカニズム獲得のKey因子となる可能性が示唆された。従ってFGFをターゲットとした肺癌に対する新規治療への展開も考えられた。
研究②:術前Monocyte-lymphocyte ratio (MLR)値は簡便に算出可能な炎症性バイオマーカーであり、病理病期IA期非小細胞肺癌における術後再発予測因子である。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Complete Blood Cell Count-Derived Inflammatory Biomarkers in Early-Stage Non-Small-Cell Lung Cancer2020

    • Author(s)
      Shoji Fumihiro、Kozuma Yuka、Toyokawa Gouji、Yamazaki Koji、Takeo Sadanori
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 26 Issue: 5 Pages: 248-255

    • DOI

      10.5761/atcs.oa.19-00315

    • NAID

      130007928557

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 病理病期IA期非小細胞肺癌における術前Systemic immune-inflammation indexの意義2019

    • Author(s)
      庄司文裕、上妻由佳、豊川剛二、山﨑宏司、竹尾貞徳
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Preoperative complete blood cell count-derived inflammation biomarkers for postoperative recurrence in early-staged non-small cell lung cancer patients2019

    • Author(s)
      Fumihiro Shoji, Yuka Kozuma, Gouji Toyokawa, Koji Yamazaki and Sadanori Takeo
    • Organizer
      2019 World Conference on Lung Cancer
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 病理病期IA期非小細胞肺癌における術前炎症性バイオマーカーの意義に関する検討2019

    • Author(s)
      庄司文裕、上妻由佳、豊川剛二、山﨑宏司、竹尾貞徳
    • Organizer
      第72回日本胸部外科学会定期学術集会
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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