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Wnt/b-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Research Project

Project/Area Number 17K10998
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Fujii Tomoko  東京大学, 医学部附属病院, 特任講師 (40793089)

Co-Investigator(Kenkyū-buntansha) 山神 良太  東京大学, 医学部附属病院, 特任臨床医 (00722191)
矢野 文子  東京大学, 医学部附属病院, 特任准教授 (80529040)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords変形性膝関節症 / Wntシグナル / βcatenin / 関節軟骨 / Prg4 / メカニカルストレス / ルブリシン / Wnt-βcatenin / 関節軟骨最表層
Outline of Final Research Achievements

In SFZ-specific β-catenin-knockout mice, OA development was significantly accelerated, which was accompanied by decreased Prg4 expression and SFZ destruction. In contrast, Prg4 expression was enhanced and cartilage degeneration was suppressed in SFZ-specific β-catenin-stabilized mice. In primary SFZ cells, Prg4 expression was downregulated by β-catenin knockout, while it was upregulated by β-catenin stabilization by exon 3 deletion or treatment with CHIR99021. Among Wnt ligands, Wnt5a, Wnt5b, and Wnt9a were highly expressed in SFZ cells, and recombinant human WNT5A and WNT5B stimulated Prg4 expression. Mechanical loading upregulated expression of these ligands and further promoted Prg4 transcription. Moreover, mechanical loading and Wnt/β-catenin signaling activation increased mRNA levels of Creb1, a potent transcription factor for Prg4.

Academic Significance and Societal Importance of the Research Achievements

Wnt-βcateninシグナルの関節軟骨最表層の保持と制御機構への関わりを生理的条件下で解明すべく、それぞれの組織・時期特異的ノックアウトマウスとトランスジェニックマウスについて変形性関節症(OA)モデルを解析した。
そのメカニズムを解明することは、関節軟骨の維持、変性予防効果のあるWnt-βcatenin修飾化合物を同定し、有望なものについてはマウスモデル上での変形性膝関節症の治療効果の検討を行い、OA新規治療候補薬の開発に繋ぐ。
Wnt-βcateninシグナルを臨床応用した場合の効果だけでなく、副作用を予期する上でも必要であり、OAの新規治療法開発に大いに貢献することは間違いない。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (43 results)

All 2020 2019 2018 2017

All Journal Article (31 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 31 results,  Open Access: 14 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Primary culture of mouse adipose and fibrous synovial fibroblasts under normoxic and hypoxic conditions2020

    • Author(s)
      SUGIMOTO Hikaru、MURAHASHI Yasutaka、CHIJIMATSU Ryota、MIWA Satoshi、YANO Fumiko、TANAKA Sakae、SAITO Taku
    • Journal Title

      Biomedical Research

      Volume: 41 Issue: 1 Pages: 43-51

    • DOI

      10.2220/biomedres.41.43

    • NAID

      130007801491

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2020-02-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling2020

    • Author(s)
      Okada Keita、Mori Daisuke、Makii Yuma、Nakamoto Hideki、Murahashi Yasutaka、Yano Fumiko、Chang Song Ho、Taniguchi Yuki、Kobayashi Hiroshi、Semba Hiroaki、Takeda Norihiko、Piao Wen、Hanaoka Kenjiro、Nagano Tetsuo、Tanaka Sakae、Saito Taku
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5425-5425

    • DOI

      10.1038/s41598-020-62463-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering2020

    • Author(s)
      Hamamoto Shuichi、Chijimatsu Ryota、Shimomura Kazunori、Kobayashi Masato、Jacob George、Yano Fumiko、Saito Taku、Chung Ung-il、Tanaka Sakae、Nakamura Norimasa
    • Journal Title

      Journal of Experimental Orthopaedics

      Volume: 7 Issue: 1 Pages: 446-458

    • DOI

      10.1186/s40634-020-00228-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion2019

    • Author(s)
      Murahashi Yasutaka、Yano Fumiko、Chijimatsu Ryota、Nakamoto Hideki、Maenohara Yuji、Amakawa Masahiro、Miyake Yoshihide、Yamanaka Hiroyuki、Iba Kousuke、Yamashita Toshihiko、Tanaka Sakae、Saito Taku
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 20329-20329

    • DOI

      10.1038/s41598-019-56861-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone2019

    • Author(s)
      Xuan Fengjun、Yano Fumiko、Mori Daisuke、Chijimatsu Ryota、Maenohara Yuji、Nakamoto Hideki、Mori Yoshifumi、Makii Yuma、Oichi Takeshi、Taketo Makoto Mark、Hojo Hironori、Ohba Shinsuke、Chung Ung-il、Tanaka Sakae、Saito Taku
    • Journal Title

      Arthritis Research & Therapy

      Volume: 21 Issue: 1 Pages: 247-247

    • DOI

      10.1186/s13075-019-2041-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds2019

    • Author(s)
      Kawata Manabu、Mori Daisuke、Kanke Kosuke、Hojo Hironori、Ohba Shinsuke、Chung Ung-il、Yano Fumiko、Masaki Hideki、Otsu Makoto、Nakauchi Hiromitsu、Tanaka Sakae、Saito Taku
    • Journal Title

      Stem Cell Reports

      Volume: 13 Issue: 3 Pages: 530-544

    • DOI

      10.1016/j.stemcr.2019.07.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation2019

    • Author(s)
      Yano Fumiko、Ohba Shinsuke、Murahashi Yasutaka、Tanaka Sakae、Saito Taku、Chung Ung-il
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 7666-7666

    • DOI

      10.1038/s41598-019-43948-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excessive mechanical loading promotes osteoarthritis through the gremlin-1?NF-κB pathway2019

    • Author(s)
      Chang Song Ho、Mori Daisuke、Kobayashi Hiroshi、Mori Yoshifumi、Nakamoto Hideki、Okada Keita、Taniguchi Yuki、Sugita Shurei、Yano Fumiko、Chung Ung-il、Kim-Kaneyama Joo-ri、Yanagita Motoko、Economides Aris、Canalis Ernesto、Chen Di、Tanaka Sakae、Saito Taku
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1442-1442

    • DOI

      10.1038/s41467-019-09491-5

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of the small compound TD ‐198946 on glycosaminoglycan synthesis and transforming growth factor β3‐associated chondrogenesis of human synovium‐derived stem cells in vitro2019

    • Author(s)
      Chijimatsu Ryota、Yano Fumiko、Saito Taku、Kobayashi Masato、Hamamoto Shuichi、Kaito Takashi、Kushioka Junichi、Hart David A.、Chung Ung‐il、Tanaka Sakae、Yoshikawa Hideki、Nakamura Norimasa
    • Journal Title

      Journal of Tissue Engineering and Regenerative Medicine

      Volume: 13 Issue: 3 Pages: 446-458

    • DOI

      10.1002/term.2795

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multi-layered PLLA-nanosheets loaded with FGF-2 induce robust bone regeneration with controlled release in critical-sized mouse femoral defects2019

    • Author(s)
      Murahashi Yasutaka、Yano Fumiko、Nakamoto Hideki、Maenohara Yuji、Iba Kousuke、Yamashita Toshihiko、Tanaka Sakae、Ishihara Kazuhiko、Okamura Yosuke、Moro Toru、Saito Taku
    • Journal Title

      Acta Biomaterialia

      Volume: 85 Pages: 172-179

    • DOI

      10.1016/j.actbio.2018.12.031

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Necessary Factors to Achieve Deep Flexion for Asian Populations after Oxford Unicompartmental Knee Arthroplasty2019

    • Author(s)
      Taketomi Shuji、Yamagami Ryota、Kawaguchi Kohei、Nakazato Keiu、Tanaka Sakae、Inui Hiroshi
    • Journal Title

      The Journal of Knee Surgery

      Volume: Epub Issue: 03 Pages: 294-300

    • DOI

      10.1055/s-0039-1678539

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meniscal bearing dislocation while rolling over in sleep following Oxford medial unicompartmental knee arthroplasty2019

    • Author(s)
      Kawaguchi Kohei、Inui Hiroshi、Taketomi Shuji、Yamagami Ryota、Kono Kenichi、Nakazato Keiu、Kawata Manabu、Tanaka Sakae
    • Journal Title

      The Knee

      Volume: 26 Issue: 1 Pages: 267-272

    • DOI

      10.1016/j.knee.2018.10.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A cooperative support model for cancer therapy and employment balance: from focus-group interviews of health and business professionals2019

    • Author(s)
      TAKAHASHI Miho、UETAKE Chika、NAKAYAMA Naoko、EURA Akiko、YAMAGUCHI Natsumi、KAMEDA Yui、MUTO Go、ENDO Motoki、KAWAMATA Kayo、FUJII Tomoko、OKA Hiroyuki、MATSUDAIRA Ko
    • Journal Title

      Industrial Health

      Volume: 57 Issue: 1 Pages: 40-51

    • DOI

      10.2486/indhealth.2018-0089

    • NAID

      130007590478

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of the ‘One Stretch’ exercise on the improvement of low back pain in Japanese nurses: A large-scale, randomized, controlled trial2019

    • Author(s)
      Oka Hiroyuki、Nomura Takuo, et al.
    • Journal Title

      Modern Rheumatology

      Volume: Epub Issue: 5 Pages: 1-6

    • DOI

      10.1080/14397595.2018.1514998

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis2018

    • Author(s)
      Murahashi Yasutaka、Yano Fumiko、Kobayashi Hiroshi、Makii Yuma、Iba Kousuke、Yamashita Toshihiko、Tanaka Sakae、Saito Taku
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16475-16475

    • DOI

      10.1038/s41598-018-34830-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of gait parameters in a mouse model of surgically induced knee osteoarthritis.2018

    • Author(s)
      Makii Y, Asaka M, Setogawa S, Fujiki S, Hosaka Y, Yano F, Oka H, Tanaka S, Fukui N, Yanagihara D, Saito T.
    • Journal Title

      J Orthop Surg (Hong Kong).

      Volume: 26 Issue: 2 Pages: 2-2

    • DOI

      10.1177/2309499018768017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between anteroposterior stability and medial?lateral stability of the bi-cruciate stabilized total knee arthroplasty2018

    • Author(s)
      Inui Hiroshi、Taketomi Shuji、Yamagami Ryota、Kawaguchi Kohei、Nakazato Keiu、Tanaka Sakae
    • Journal Title

      The Knee

      Volume: 25 Issue: 6 Pages: 1247-1253

    • DOI

      10.1016/j.knee.2018.08.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical timing of anterior cruciate ligament reconstruction to prevent associated meniscal and cartilage lesions2018

    • Author(s)
      Taketomi S, Inui H, Yamagami R, Kawaguchi K, Nakazato K, Kono K, Kawata M, Nakagawa T, Tanaka S
    • Journal Title

      J Orthop Sci

      Volume: 23 Issue: 3 Pages: 546

    • DOI

      10.1016/j.jos.2018.02.006

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of low back load with low back pain during static standing2018

    • Author(s)
      Hasegawa Tetsuya、Katsuhira Junji、Oka Hiroyuki、Fujii Tomoko、Matsudaira Ko
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: e0208877-e0208877

    • DOI

      10.1371/journal.pone.0208877

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between neck and shoulder discomfort?Katakori?and high somatizing tendency2018

    • Author(s)
      Fujimoto Yoh、Fujii Tomoko、Oshima Yasushi、Oka Hiroyuki、Tanaka Sakae、Matsudaira Ko
    • Journal Title

      Modern Rheumatology

      Volume: Epub Issue: 1 Pages: 1-6

    • DOI

      10.1080/14397595.2018.1551177

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology.2018

    • Author(s)
      Fujii Y, Kawase-Koga Y, Hojo H, Yano F, Sato M, Chung UI, Ohba S, Chikazu D.
    • Journal Title

      Stem Cell Res Ther

      Volume: 9 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s13287-018-0783-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between somatic symptom burden and health-related quality of life in people with chronic low back pain2018

    • Author(s)
      Fujii T, Oka H, Katsuhira J, Tonosu J, Kasahara S, Tanaka S, Matsudaira K
    • Journal Title

      PLoS One

      Volume: 13 Issue: 2 Pages: e0193208-e0193208

    • DOI

      10.1371/journal.pone.0193208

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disability due to knee pain and somatising tendency in Japanese adults2018

    • Author(s)
      Fujii T, Oka H, Katsuhira J, Tonosu J, Kasahara S, Tanaka S, Matsudaira K
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 19 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s12891-018-1940-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study)2018

    • Author(s)
      Oka H, Matsudaira K, Takano Y, Kasuya D, Niiya M, Tonosu J, Fukushima M, Oshima Y, Fujii T, Tanaka S, Inanami H
    • Journal Title

      BMC Complement Altern Med

      Volume: 18 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s12906-018-2087-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Relationship between Soft-Tissue Balance and Intraoperative Kinematics of Guided Motion Total Knee Arthroplasty2018

    • Author(s)
      Taketomi Shuji、Yamagami Ryota、Shirakawa Nobuyuki、Kawaguchi Kouhei、Tanaka Sakae、Inui Hiroshi
    • Journal Title

      The Journal of Knee Surgery

      Volume: 印刷中 Issue: 01 Pages: 091-096

    • DOI

      10.1055/s-0038-1636545

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Mouse Intervertebral Disc Degeneration Model by Surgically-Induced Instability2017

    • Author(s)
      Oichi T, Taniguchi Y, Soma K, Chang SH, Yano F, Tanaka S, Saito T
    • Journal Title

      Spine

      Volume: ― Issue: 10 Pages: 1-1

    • DOI

      10.1097/brs.0000000000002427

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Mouse Intervertebral Disc Degeneration Model by Surgically-Induced Instability2017

    • Author(s)
      Oichi T, Taniguchi Y, Soma K, Chang SH, Yano F, Tanaka S, Saito T
    • Journal Title

      Spine

      Volume: Epub

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sandwich-type PLLA-nanosheets loaded with BMP-2 induce bone regeneration in critical-sized mouse calvarial defects2017

    • Author(s)
      Huang KC, Yano F, Murahashi Y, Takano S, Kitaura Y, Chang SH, Soma K, Ueng SWN, Tanaka S, Ishihara K, Okamura Y, Moro T, Saito T
    • Journal Title

      Acta Biomater

      Volume: 59 Pages: 12-20

    • DOI

      10.1016/j.actbio.2017.06.041

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epidemiology and psychological factors of whiplash associated disorders in Japanese population2017

    • Author(s)
      Oka H, Matsudaira K, Fujii T, Tanaka S, Kitagawa T
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 29 Issue: 9 Pages: 1510-1513

    • DOI

      10.1589/jpts.29.1510

    • NAID

      130006078015

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic psychosocial factors for disabling low back pain in Japanese hospital workers2017

    • Author(s)
      Yoshimoto T, Oka H, Katsuhira J, Fujii T, Masuda K, Tanaka S, Matsudaira K
    • Journal Title

      PLoS One

      Volume: 12 Issue: 5 Pages: e0177908-e0177908

    • DOI

      10.1371/journal.pone.0177908

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone-Patellar Tendon-Bone Autograft versus Hamstring Tendon Autograft for Anatomical Anterior Cruciate Ligament Reconstruction with Three-Dimensional Validation of Femoral and Tibial Tunnel Positions2017

    • Author(s)
      Inui Hiroshi、Yamagami Ryota、Shirakawa Nobuyuki、Kawaguchi Kohei、Nakagawa Takumi、Tanaka Sakae、Taketomi Shuji
    • Journal Title

      The Journal of Knee Surgery

      Volume: 31 Issue: 9 Pages: 866

    • DOI

      10.1055/s-0037-1615813

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] TRPV2 protects articular cartilage via lubricin induction2020

    • Author(s)
      Nakamoto H, Yano F, Saito T, et al
    • Organizer
      ORS 2020 Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ルブリシンは関節軟骨最表層細胞の分化を抑制し、関節軟骨の恒常性を維持する2019

    • Author(s)
      前之原悠司、矢野文子、齋藤琢、他
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] メカノセンサーTrpv2 はLubricin の誘導を介して関節軟骨を保護する2019

    • Author(s)
      中元秀樹、矢野文子、齋藤琢、他
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 膝関節軟骨欠損モデルを用いたマウス滑膜細胞の軟骨再生誘導能の検討2019

    • Author(s)
      三輪哲史、矢野文子、齋藤琢、他
    • Organizer
      第37回日本骨代謝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Taceは変形性関節症を促進的に制御する2019

    • Author(s)
      金子泰三、矢野文子、齋藤琢、他
    • Organizer
      第37回日本骨代謝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Runx3は関節軟骨に保護的に作用する2018

    • Author(s)
      永田向生、矢野文子、齋藤琢 他
    • Organizer
      第33回日本整形外科学会基礎学術集会、第36回日本骨代謝学会
    • Related Report
      2018 Research-status Report
  • [Presentation] I kappa B alphaキナーゼ阻害剤の関節内投与はNF-kappa Bの制御を介して変形性関節症モデルマウスの病態進行を抑制する2018

    • Author(s)
      村橋靖崇、矢野文子、齋藤琢 他
    • Organizer
      第33回日本整形外科学会基礎学術集会、第36回日本骨代謝学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Adamts17はmicrofibril形成を介してTGF-βシグナルを調整し、骨格成長に関与する2018

    • Author(s)
      尾市健、矢野文子、齋藤琢、他
    • Organizer
      第33回日本整形外科学会基礎学術集会、第36回日本骨代謝学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 関節軟骨の維持・変性を制御するシグナル群2018

    • Author(s)
      矢野文子、齋藤琢
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] β-cateninシグナルは関節軟骨最表層の維持に必須である2018

    • Author(s)
      玄 峰俊、矢野 文子、斎藤 琢
    • Organizer
      第31回日本軟骨代謝学会
    • Related Report
      2017 Research-status Report
  • [Presentation] β-cateninシグナルは関節軟骨最表層の維持に必須である2017

    • Author(s)
      玄 峰俊、矢野 文子、斎藤 琢
    • Organizer
      第35回日本骨代謝学会、第32回日本整形外科学会基礎
    • Related Report
      2017 Research-status Report
  • [Presentation] 関節軟骨最表層に発現する転写因子 HIF-2α は,関節軟骨の維持に不可欠である2017

    • Author(s)
      牧井 勇磨、矢野 文子、斎藤 琢
    • Organizer
      第35回日本骨代謝学会、第32回日本整形外科学会基礎
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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