Role of CDKN1C in hypopharyngeal cancer

• Project/Area Number: 17K11414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Imai Takayuki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (80408583)
• Co-Investigator(Kenkyū-buntansha): 望月 麻衣 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 研究員 (40726303)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 頭頸部がん / 扁平上皮癌 / 頭頸部癌 / 頭頚部癌 / CD271 / CDKN1C / 細胞増殖 / 下咽頭癌

Outline of Final Research Achievements

Head and neck cancer is a common cancer worldwide and its incidense is slowly increasing in Japan. Previously we investigated the CD271-CDKN1C pathway in hypopharyngeal cancer, and in this study we newly established an anti-CD271 antibody for treatment. The antibody exerts ADCC activity and shows a tumor-reducing effect in vivo. These results demonstrate the feasibility of antibody treatiment targeting CD271.

Academic Significance and Societal Importance of the Research Achievements

私たちは頭頸部がんの新規治療法確立のために、がん幹細胞マーカーであるCD271に対する抗体を作成し、治療できるか検討した。その結果、担癌マウスにおいて抗体投与群では腫瘍縮小効果を得られた。今後はさらに改善を行い、実用化を目指す。

Research Products

• [Journal Article] Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271 (2020)
  • Author(s): Morita Shinkichi、Mochizuki Mai、Shibuya-Takahashi Rie、Nakamura-Shima Mao、Yamazaki Tomoko、Imai Takayuki、Asada Yukinori、Matsuura Kazuto、Kawamura Sadafumi、Yamaguchi Kazunori、Yasuda Jun、Sugamura Kazuo、Katori Yukio、Satoh Kennichi、Tamai Keiichi
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 39 Issue: 1 Pages: 6-11
  • DOI: 10.1089/mab.2019.0040
  • Peer Reviewed
• [Journal Article] Risk factors for cervical lymph node metastasis in endoscopically resected superficial hypopharyngeal cancers (2019)
  • Author(s): Imai Takayuki、Ito Shigemi、Oikawa Tomoyuki、Asada Yukinori、Matsumoto Ko、Miyazaki Takefumi、Yamazaki Tomoko、Satoh Ikuro、Noguchi Tetsuya、Matsuura Kazuto
  • Journal Title: Auris Nasus Larynx Volume: 46 Issue: 3 Pages: 424-430
  • DOI: 10.1016/j.anl.2018.09.005
  • NAID: 130007895065
  • Peer Reviewed
• [Journal Article] Enhanced Recovery After Surgery program with dexamethasone administration for major head and neck surgery with free tissue transfer reconstruction: initial institutional experience (2018)
  • Author(s): Imai Takayuki、Kurosawa Koreyuki、Yamaguchi Kayo、Satake Naoko、Asada Yukinori、Matsumoto Ko、Morita Sinkichi、Saijo Satoshi、Aoi Jiro、Fujii Keitaro、Kishimoto Kazuhiro、Goto Takahiro、Matsuura Kazuto
  • Journal Title: Acta Oto-Laryngologica Volume: 138 Issue: 7 Pages: 664-669
  • DOI: 10.1080/00016489.2018.1429651
  • Peer Reviewed / Open Access
• [Journal Article] Laryngeal function-preserving operation for T4a laryngeal cancer with vocal cord paralysis ? A case report (2018)
  • Author(s): Asada Yukinori、Kurosawa Koreyuki、Matsumoto Ko、Goto Takahiro、Katoh Kengo、Imai Takayuki、Saijo Shigeru、Matsuura Kazuto
  • Journal Title: Auris Nasus Larynx Volume: 45 Issue: 1 Pages: 194-199
  • DOI: 10.1016/j.anl.2017.03.012
  • Peer Reviewed
• [Journal Article] 唾液腺腫瘍の治療方針 (2018)
  • Author(s): 今井隆之，松浦一登
  • Journal Title: JHONS Volume: 34(4) Pages: 437-440
• [Journal Article] A Novel Funnel-Shaped Flap for Reconstruction Surgery after Total Laryngopharyngectomy with Total Glossectomy (2017)
  • Author(s): Kurosawa Koreyuki、Asada Yukinori、Matsumoto Ko、Imai Takayuki、Matsuura Kazuto、Goto Takahiro
  • Journal Title: Plastic and Reconstructive Surgery - Global Open Volume: 5 Issue: 9 Pages: e1504-e1504
  • DOI: 10.1097/gox.0000000000001504
  • Peer Reviewed
• [Journal Article] 下咽頭癌における癌幹細胞表面マーカーの同定とその機能解析 (2017)
  • Author(s): 今井隆之，望月麻衣，森田真吉，西條聡，玉井恵一，松浦一登
  • Journal Title: 頭頸部癌 Volume: 43 Pages: 339-344
  • NAID: 130006219673