Development of molecular markers for functional prognosis and treatment of posttraumatic acute kidney injury (AKI) tubular repair

• Project/Area Number: 17K11586
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: NASU Toru 和歌山県立医科大学, 医学部, 講師 (60393310)
• Co-Investigator(Kenkyū-buntansha): 上田 健太郎 和歌山県立医科大学, 医学部, 准教授 (20438279) ; 米満 尚史 和歌山県立医科大学, 医学部, 講師 (80382331)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 外傷 / 急性腎障害 / AKI / 予測分子マーカー / 尿細管 / CITED1 / 出血性ショック / 外傷後急性腎障害 / 脱分化 / 分子マーカー / 腎虚血再潅流モデル / 高エネルギー外傷

Outline of Final Research Achievements

After an injury or accident, a person may suffer from acute kidney injury (AKI), a disease in which the kidneys, the organs in the body that produce urine, fail to function properly, causing toxins to accumulate in the body and sometimes leading to a life-threatening condition. The disease can cause toxins to accumulate in the body, sometimes resulting in a life-threatening condition.
The purpose of my research is to find substances that are involved in the repair and treatment of the tubules in the kidneys. This will help prevent AKI after traumatic injuries and lead to the discovery of effective treatments and remedies.

Academic Significance and Societal Importance of the Research Achievements

臨床的検討により、外傷後急性腎障害の発症を予測する臨床因子として「病院前収縮期血圧」と「救急外来での乳酸値」が候補になることを発見しました。一方分子生物学的検討も行いましたが、こちらは未だ予測分子マーカーを同定するに至っていません。
ケガや事故などにより外傷を受けた後に、せっかくケガが治ってもAKIにより障害を残したり、命を落とす方がいます。この研究により、このような人をひとりでも減らすことに貢献できます。特に若い人や働き盛りの人がAKIにならないようにすることは、その人だけでなく、家族や社会を救うことにもつながります。

Research Products

• [Journal Article] Prediction of early acute kidney injury after trauma using prehospital systolic blood pressure and lactate levels: A prospective validation study (2022)
  • Author(s): Nasu Toru、Ueda Kentaro、Kawashima Shuji、Okishio Yuko、Kunitatsu Kosei、Iwasaki Yasuhiro、Kato Seiya
  • Journal Title: Injury Volume: 53 Issue: 1 Pages: 81-85
  • DOI: 10.1016/j.injury.2021.09.039
  • Peer Reviewed / Open Access
• [Journal Article] Prehospital Blood Pressure and Lactate are Early Predictors of Acute Kidney Injury After Trauma (2021)
  • Author(s): Nasu Toru、Ueda Kentaro、Kawashima Shuji、Okishio Yuko、Kunitatsu Kosei、Iwasaki Yasuhiro、Kato Seiya
  • Journal Title: Journal of Surgical Research Volume: 265 Pages: 180-186
  • DOI: 10.1016/j.jss.2021.03.037
  • Peer Reviewed
• [Presentation] Prehospital systolic blood pressure and lactate are early predictors of acute kidney injury after trauma: a prospective validation study. (2020)
  • Author(s): Nasu Toru
  • Organizer: American Society of Nephrology Kidney Annual Meeting
  • Int'l Joint Research
• [Presentation] 病院前収縮期血圧と乳酸値は外傷後の急性腎障害（AKI）の予測因子となり得る：前向き検証研究 (2020)
  • Author(s): 那須亨
  • Organizer: 第48回日本救急医学会総会・学術集会
• [Presentation] Lactate and prehospital blood pressure may be useful for the early prediction of acute kidney injury after trauma. (2019)
  • Author(s): 那須亨
  • Organizer: 36th ACEM
  • Int'l Joint Research
• [Presentation] 外傷後急性腎障害のリスク因子とドクヘリ搬送による予後の検討 (2019)
  • Author(s): 那須亨
  • Organizer: 第26回日本航空医療学会
• [Presentation] 外傷後急性腎障害のリスク因子と劇的救命例についての検討 (2019)
  • Author(s): 那須亨
  • Organizer: 第33回日本外傷学会
• [Presentation] 外傷後急性腎障害のリスク因子と劇的救命例についての検討 (2019)
  • Author(s): 那須亨
  • Organizer: 第３３回日本外傷学会
• [Presentation] A case of traumatic shock in which hepatic hemorrhaging was controlled and the patient’s life was saved using an Intra-Aortic Balloon Occlusion catheter. (2018)
  • Author(s): Toru NASU
  • Organizer: 2018EVT(EndoVascular resccucitation and Trauma Management)
  • Int'l Joint Research