Importance for the existence of mobile-genetic elements in cytotoxic Anginosus group streptococci
| Project/Area Number |
17K11615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TABATA Atsushi 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 講師 (10432767)
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| Co-Investigator(Kenkyū-buntansha) |
友安 俊文 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 准教授 (20323404)
長宗 秀明 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 教授 (40189163)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アンギノーサス群レンサ球菌 / Streptococcus anginosus / β溶血 / ストレプトリジンS / 可動性遺伝因子 / プラスミド / Toxin-antitoxin system / ファージ / アンギノーサス群連鎖球菌 / 口腔細菌学 |
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| Outline of Final Research Achievements |
Streptococcus anginosus subsp. anginosus is an opportunistic pathogen habitual in the oral cavity of human. Some of this species show cytotoxicity by producing the peptide-type toxin named streptolysin S. This study was conducted to investigate the presence of “mobile-genetic elements”, such as plasmids and bacteriophages, that may give the novel characteristics such as pathogenicity and/or antibiotic resistance, and to reveal the functions of these elements in the species. From the result of this study, the presence of plasmid and the induction of lysogenic phage was observed in the strain of S. anginosus subsp. anginosus, and their molecular characters were investigated based on the genetic information of these elements. The results shown in this study will provide the important information to discuss the real pathogenicity of human commensal S. anginosus subsp. anginosus strains and to enlighten the adequate oral health of human.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、ヒト口腔に常在するレンサ球菌であるStreptococcus anginosus subsp. anginosusの中に、可動性遺伝因子であるプラスミドや溶原ファージを保有する株が存在していることを明らかにした。細菌は、可動性遺伝子因子の獲得によって表現型が変化する可能性があり、ヒト口腔内に常在する日和見病原菌である本菌種において可動性遺伝因子の存在が確認されたことは、本菌の潜在的な病原性を議論する上で、また適切なオーラルケアを啓蒙する上でも、重要な知見であると考える。
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Report
(4 results)
Research Products
(8 results)
