The development of new multi-functional materials based on the ZnO/CuO nanocomposite
| Project/Area Number |
17K11712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
奥山 克史 朝日大学, 歯学部, 准教授 (00322818)
阿部 薫明 北海道大学, 歯学研究院, 助教 (40374566)
山本 洋子 大阪大学, 歯学研究科, 招へい教員 (60448107)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノコンポジット / 抗菌性 / バイオミネラリゼーション / マイクロビーム / 微量元素 / 象牙質劣化 / 金属ナノ粒子 / 再石灰化 / イオンビーム分析 / 象牙質接着 / ナノ粒子 / 抗菌作用 / フッ素 / 脱灰再石灰化 / PIXE/PIGE / PIXE/PIGE法 / ナノ材料 |
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| Outline of Final Research Achievements |
Dental materials that are antimicrobial and acid-resistant can inhibit bacterial colonization and demineralization, thereby preventing caries. Zinc and copper are well-known for their antibacterial effect, as is nanostructured ZnO/CuO composite. Minerals such as fluorine and calcium, can remineralize and demineralize teeth. Therefore, we developed novel fluoride-containing ZnO/CuO (ZCF) nanocomposites; to the best of our knowledge, these are the first nanocomposites of this kind. The ZCF nanocomposites were composed of 3D flower-like microstructures with diameters of approximately one μm. SEM-EDS analysis revealed that ZCF contained 47.5% Cu, 40.5% Zn, 6.7% F, and 5.9% Cl. Analysis by PIGE showed that ZCF nanocomposite contained 2553.6 ± 199.2 ppm fluorine. The control buffer enabled bacterial growth to 4×107 ± 9×106 CFU/mL, whereas ZCF showed no bacterial growth.
Thus, we developed novel fluoride-containing ZnO/CuO nanocomposites, which exhibited antibacterial effects.
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会への変化とともに根面う蝕は増加の一途をたどっており、さらに口腔内常在菌による誤嚥性肺炎の予防も重要な課題の一つである。したがって口腔内の細菌の増殖を抑制し象牙質の劣化を抑制する材料の開発は人の健康維持に重要である。亜鉛、銅、フッ素の元素を組み合わせることによって、イオン徐放性と抗菌性を持つ微粒子の開発に成功した。これらの微粒子は人に必須の微量元素の1つである亜鉛、銅、フッ素を用いて簡易に作製することが可能であることから、今後はさらなるバイオアクティビティの検討と共に広く臨床に応用される可能性が考えられる。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Antibacterial effect of a fluoride-containing ZnO/CuO nanocomposite2019
Author(s)
Matsuda Y, Okuyama K, Yamamoto H, Fujita M, Abe S, Sato T, Yamada N, Koka M, Sano H, Hayashi M, Sidhu SK, Saito T
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Journal Title
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
Volume: 458
Pages: 184-188
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Charge and controlled release of epigallocatechin gallate by glass ionomer cement containing nanoporous silica particles2017
Author(s)
K. Nakamura, K. Nakanishi, Y. Bando, A. Hasebe, A. Hyono, S. Abe, K. Shibata, Y. Yoshida, J. Iida, and Y. Yawaka
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Journal Title
Nano Biomedicine,
Volume: 9
Pages: 112-116
NAID
Related Report
Peer Reviewed / Open Access
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