Maternal periodontal disease induce fetal failure and postnatal glucose intolerance

• Project/Area Number: 17K11982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Katagiri Sayaka 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60510352)
• Co-Investigator(Kenkyū-buntansha): 高橋 宏和 佐賀大学, 医学部, 講師 (20607783)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯周病 / 妊娠 / 低体重児出産 / 糖尿病

Outline of Final Research Achievements

Growing evidence indicates an association between periodontitis and delivery outcome; however, the mechanism is unclear. This study aimed to investigate the influence of Porphyromonas gingivalis (Pg) infection on delivery outcome.
In the human study, lower anti‐P. gingivalis IgG‐1 amounts are related to threatened preterm birth, while higher anti‐P. gingivalis IgG and IgG‐4 are related with small for gestational age in threatened preterm birth.
A bacteremia model mouse was created by intravenous injection of Pg to pregnant Slc: ICR mice. Pg infection during the third trimester caused low birth weight and inflammation in the placenta and umbilical cord.

Academic Significance and Societal Importance of the Research Achievements

早産・低体重児は新生児の疾病罹患率、死亡率を増加させる有害な病態である。また、胎児発育不全は出生後の予後が不良となることもあり、周産期死亡率や精神発達遅滞の発症率も高く、成人後も疾病罹患率が高いなど軽視できない病態である。
本研究はP. gingivalis感染が低出生体重児出産を引き起こすことヒトおよびマウスモデルで示した点が非常に興味深く、歯周病が早産・低体重児出産に影響を及ぼすメカニズム解明の一助となることが期待できる。

Research Products

• [Journal Article] The relationship between the anti-Porphyromonas gingivalis immunoglobulin G subclass antibody and small for gestational age delivery: a longitudinal study in pregnant Japanese women (2020)
  • Author(s): Ye Changchang、Kobayashi Hiroaki、Katagiri Sayaka、Miyasaka Naoyuki、Takeuchi Yasuo、Kuraji Ryutaro、Izumi Yuichi
  • Journal Title: International Dental Journal Volume: - Issue: 4 Pages: 296-302
  • DOI: 10.1111/idj.12548
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin-induced diabetic mice (2019)
  • Author(s): Ohtsu Anri、Takeuchi Yasuo、Katagiri Sayaka、Suda Wataru、Maekawa Shogo、Shiba Takahiko、Komazaki Rina、Udagawa Sayuri、Sasaki Naoki、Hattori Masahira、Izumi Yuichi
  • Journal Title: Oral Diseases Volume: 25(3) Issue: 3 Pages: 868-880
  • DOI: 10.1111/odi.13044
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Effects of Ultraviolet Light-Emitting Diodes with Different Wavelengths on Periodontopathic Bacteria In Vitro (2019)
  • Author(s): Aung Nay、Aoki Akira、Takeuchi Yasuo、Hiratsuka Koichi、Katagiri Sayaka、Kong Sophannary、Shujaa Addin Ammar、Meinzer Walter、Sumi Yasunori、Izumi Yuichi
  • Journal Title: Photobiomodulation, Photomedicine, and Laser Surgery Volume: 37 Issue: 5 Pages: 288-297
  • DOI: 10.1089/photob.2018.4514
  • Peer Reviewed
• [Journal Article] Evaluation of bone healing following Er:YAG laser ablation in rat calvaria compared with bur drilling (2018)
  • Author(s): Ohsugi Yujin、Aoki Akira、Mizutani Koji、Katagiri Sayaka、Komaki Motohiro、Noda Masahiro、Takagi Toru、Kakizaki Sho、Meinzer Walter、Izumi Yuichi
  • Journal Title: Journal of Biophotonics Volume: 12 Issue: 3
  • DOI: 10.1002/jbio.201800245
  • Peer Reviewed / Open Access
• [Journal Article] Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice (2018)
  • Author(s): Sasaki Naoki、Katagiri Sayaka、Komazaki Rina、Watanabe Kazuki、Maekawa Shogo、Shiba Takahiko、Udagawa Sayuri、Takeuchi Yasuo、Ohtsu Anri、Kohda Takashi、Tohara Haruka、Miyasaka Naoyuki、Hirota Tomomitsu、Tamari Mayumi、Izumi Yuichi
  • Journal Title: Frontiers in Microbiology Volume: 9 Pages: 2470-2470
  • DOI: 10.3389/fmicb.2018.02470
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Author Correction: Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism. (2018)
  • Author(s): Komazaki R, Katagiri S, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
  • Journal Title: Sci Rep. Volume: 12;8(1) Issue: 1 Pages: 4620-4620
  • DOI: 10.1038/s41598-018-23000-6
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Porphyromonas gingivalis infection in the placenta and umbilical cord in pregnant mice with low birth weight (2018)
  • Author(s): Udagawa Sayuri、Katagiri Sayaka、Maekawa Shogo、Takeuchi Yasuo、Komazaki Rina、Ohtsu Anri、Sasaki Naoki、Shiba Takahiko、Watanabe Kazuki、Ishihara Kazuyuki、Sato Noriko、Miyasaka Naoyuki、Izumi Yuichi
  • Journal Title: Acta Odontologica Scandinavica Volume: 15 Issue: 6 Pages: 1-9
  • DOI: 10.1080/00016357.2018.1426876
  • Peer Reviewed / Open Access
• [Presentation] Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolis. (2017)
  • Author(s): Katagiri S, Komazaki R, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y.
  • Organizer: The 103rd Annual Meeting of American Academy of Periodontology
  • Int'l Joint Research