Establishment of rat model in patellofemoral osteoarthritis and histopathological changes induced by mechanical load
| Project/Area Number |
17K13051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 変形性膝関節症 / 関節軟骨 / 滑膜 / 膝蓋下脂肪体 / 非荷重環境 / 組織学 / 膝蓋大腿関節 / 膝蓋大腿関節症 / 理学療法 / 基礎研究 / メカニカルストレス |
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| Outline of Final Research Achievements |
The purpose of this study was to examine the following three things histologically.; ①Establishment of osteoarthritis (OA) rat model in patellofemoral joint induced by MIA, ②Effect of joint loading on the progression of OA, ③Effect of unloading environment on joint compoenents.
As a result, this study revealed the following findings.; ① Intra-articular injection of MIA induced the typical histological changes in the patellofemoral joint, ② Joint unloading inhibits articular cartilage degeneration in knee joint, ③ Unloading environment caused disuse histological changes in the articular cartilage, however, it caused no critical histological changes to the synovial membrane or infrapatellar fat pad.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は「研究成果の概要」に述べた3つの点を組織学的に明らかにした。本研究で得られた新たな知見はいずれも理学療法分野で不足していた運動器における組織学的エビデンスを構築するものである。したがって、今後エビデンスに基づいた理学療法の確立に寄与するものであり、臨床上での治療に有益な知見であると考える。
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Report
(4 results)
Research Products
(6 results)
