Developing Novel Physical Therapy for Enhancing Peripheral Nerve Regeneration by Low-Intensity Pulsed Ultrasound
Project/Area Number |
17K13052
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Rehabilitation science/Welfare engineering
|
Research Institution | Kyoto University |
Principal Investigator |
Ito Akira 京都大学, 医学研究科, 助教 (50762134)
|
Project Period (FY) |
2017-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 超音波 / 物理療法 / 末梢神経 / 理学療法 / リハビリテーション / 三次元動作解析 / 再生 / 低出力超音波パルス / 末梢神経再生 |
Outline of Final Research Achievements |
We investigated the effect of a low-intensity pulsed ultrasound therapy on the regeneration of the peripheral nerve in rats. We found that 140 mW/cm2 intensity of the ultrasound enhanced the regeneration most and increased the number of regenerated axons and the thickness of the myelin sheath compared to those of control group. In addition, we suggested that the suppression of the nerve growth inhibitor gene expression would be, in part, attributed to this effects.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究では、実験動物を用いた手法を用いて末梢神経再生にとって適切な超音波刺激強度を明らかにした。さらに末梢神経再生を促進する超音波治療の作用メカニズムを一部解明していることから、超音波を用いた末梢神経再生治療における基盤的な知見を加えるものとして意義深いと考えられる。また、本研究では新たに三次元動作解析手法を用いた運動機能評価システムを確立した。運動機能評価は治療効果判定の重要な指標となることから、今後の研究においても有用と考えらえる。
|
Report
(3 results)
Research Products
(25 results)
-
-
-
-
-
-
-
[Journal Article] Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model2017
Author(s)
Iijima H, Ito A, Nagai M, Tajino J, Yamaguchi S, Kiyan W, Nakahata A, Zhang J, Wang T, Aoyama T, Nishitani K, Kuroki H
-
Journal Title
Osteoarthritis and Cartilage
Volume: 印刷中
Issue: 6
Pages: 964-975
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
[Presentation] Disruptive Effect of Simulated Microgravity on Circadian Activity Rhythm of Rats and Intensity-Dependent Counter Effect of Intermittent Centrifugation2017
Author(s)
J. Tajino, A. Ito, M. Nagai, S. Yamaguchi, H. Iijima, W. Kiyan, A. Nakahata, J. Zhang, T. Wang, T. Aoyama, H. Kuroki
Organizer
第52回日本理学療法学術大会
Related Report
-
-
-
-
[Presentation] 変形性膝関節症に対する間葉系幹細胞治療におけるリハビリテーション: システマティックレビュー2017
Author(s)
飯島弘貴, 井所拓哉, 長井桃子, 伊藤明良, 太治野純一, 中畑晶博, 喜屋武弥, 張ジュエ, 王天舒, 黒木裕士, 青山朋樹
Organizer
第52回日本理学療法学術大会
Related Report
-
-
-
-
-