Chemopreventive effect of anti-allergy drug as drug-repositioning on pancreatic carcinogenesis
| Project/Area Number |
17K15666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HItoyuki Kato 名古屋市立大学, 医薬学総合研究院(医学), 助教 (80791293)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵癌 / 抗アレルギー薬 / 化学予防 / ロイコトリエン受容体拮抗薬 / ハムスター / ドラッグリポジショニング / 発癌抑制 / アレルギー / 膵発癌 / 腫瘍 |
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| Outline of Final Research Achievements |
Previous epidemiological study reported that incidence of pancreatic ductal carcinoma (PDAC) is low in patients who have allergy, in particular received treatment for long time. Thus, we hypothesized that anti-allergy drugs have chemopreventive effect against PDACs. In hamster PDAC model, only Montelukast (Mont), one of leukotriene antagonist, prevented pancreatic carcinogenesis in four drugs. As one mechanism, Mont modulate secretion from pancreatic stellate cells, and it may be involved in down-regulation of proliferation via Smad3 pathway.
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| Academic Significance and Societal Importance of the Research Achievements |
膵癌は治療抵抗性で、５年生存率の最も悪い固形癌の一つであるため、膵癌になる前予防するという化学予防という考え方も重要になる。さらに、近年ドラッグリポジショニングという考え方は安全性の担保された薬剤を用いるということで臨床応用につながる可能性は高い。その中で疫学調査を元に、ロイコトリエン受容体拮抗薬が膵発癌予防剤として有効であるとin vivoで証明出来たことは、同薬を膵発癌に対するドラッグリポジショニング薬として用いる臨床基盤として示す事が出来たことは意義深く、社会に対する還元力も高い。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses castration-resistant prostate cancer growth via regulation of apoptosis and autophagy.2019
Author(s)
Etani T, Naiki T, Naiki-Ito A, Suzuki T, Iida K, Nozaki S, Kato H, Yagayasu Y, Suzuki S, Kawai N, Yasui T, Takahashi S.
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Journal Title
J Clin Med.
Volume: 8
Issue: 4
Pages: 442-442
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Short-term detection of gastric genotoxicity using the DNA double-strand break marker γ-H2AX2019
Author(s)
Okabe A, Kiriyama Y, Suzuki S, Sakurai K, Teramoto A, Kato H, Naiki-Ito A, Tahara S, Takahashi S, Kuroda M, Sugioka A, Tsukamoto T.
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Journal Title
Journal of Toxicologic Pathology
Volume: 32
Issue: 2
Pages: 91-99
DOI
NAID
ISSN
0914-9198, 1881-915X
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic impact of TP53INP1 gene expression in estrogen receptor α-positive breast cancer patients.2019
Author(s)
Nishimoto M, Nishikawa S, Kondo N, Wanifuchi-Endo Y, Hato Y, Hisada T, Dong Y, Okuda K, Sugiura H, Kato H, Takahashi S, Toyama T
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Journal Title
Jpn J Clin Oncol
Volume: 49
Issue: 6
Pages: 567-575
DOI
Related Report
Peer Reviewed
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[Journal Article] An Autopsy Case of Pulmonary Tumor Thrombotic Microangiopathy Due to Rapidly Progressing Colon Cancer in a Patient with Type 2 Diabetes2018
Author(s)
Ohguchi H, Imaeda K, Hotta A, Kakoi S, Yasuda S, Shimizu Y, Hayakawa A, Mishina H, Hasegawa C, Ito S, Ogawa K, Yagi T, Koyama H, Tanaka T, Kato H, Takahashi S, Joh T.
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Journal Title
Internal Medicine
Volume: 57
Issue: 17
Pages: 2533-2539
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-09-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cyclohexanone curcumin analogs inhibit the progression of castration-resistant prostate cancer in vitro and in vivo.2018
Author(s)
Mapoung, S., Suzuki, S., Fuji, S., Naiki-Ito, A., Kato, H., Yodkeeree, S., Ovatlarnporn, C., Takahashi, S., Limtrakul, P.
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Journal Title
Cancer Science
Volume: 110
Issue: 2
Pages: 596-607
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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