Deciphering the bacterial cell division machinery using advanced imaging methods
Project/Area Number |
17K15694
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including mycology)
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Research Institution | Okinawa Institute of Science and Technology Graduate University |
Principal Investigator |
Soederstroem Bill 沖縄科学技術大学院大学, 構造細胞生物学ユニット, 研究員 (00773988)
|
Project Period (FY) |
2017-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | Drug development / Microscopy / Bacteriology / fluorescence / STED / FtsZ / Bacteria / Drug resistance |
Outline of Final Research Achievements |
Bacterial cell division was examined using high resolution fluorescence microscopy. In a combination of microscopy and nanofabrication approach were cells placed in a standing position and imaged. This change of perspective made it possible to achieve better resolution and, in that way, extract more information from each image. In a second step was cells reshaped into unnatural shapes like heart, stars and square to investigate how robust the cell division machinery is. We conclude that the cell division machinery is no sensitive to changes in the membrane geometry.
|
Academic Significance and Societal Importance of the Research Achievements |
Advancement of our general understanding of bacterial cell division has lead to better possibilities to develop new antibiotics.
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Report
(3 results)
Research Products
(12 results)