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The measurement of acetaldehyde in human esophageal and gastric tissue and the effect of L-cysteine for reducing the incidence of esophageal and gastric cancers

Research Project

Project/Area Number 17K15917
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

Hatta Waku  東北大学, 大学病院, 助教 (30706932)

Research Collaborator Okata Hideki  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアセトアルデヒド / L-システイン / L-システイン製剤
Outline of Final Research Achievements

We enrolled 10 subjects with active acetaldehyde dehydrogenase-2*1/*1 genotype and 10 subjects with the inactive acetaldehyde dehydrogenase-2*1/*2 genotype. In this study using L-cysteine and placebo lozenges, saliva and blood were collected and esophageal and gastric tissue was obtained after drinking. Then, the acetaldehyde and ethanol concentrations were measured. The acetaldehyde concentration of the saliva was significantly lower in those taking L-cysteine than in those taking the placebo. Acetaldehyde in the esophageal tissue was detected only in those taking L-cysteine lozenges.

Academic Significance and Societal Importance of the Research Achievements

これまでにヒト生体内での食道組織からアセトアルデヒドを検出した報告はなく、本研究にてヒト生体内食道組織のアセトアルデヒドが初めて検出されたことは意義深い。L-システイン製剤投与例のみでアセトアルデヒドが検出されたことは意義深い結果である。これらより、食道組織へのアセトアルデヒドの曝露の経路として、これまでに最も有力と考えられてきた唾液の直接曝露とは異なる経路が存在する可能性が考えられた。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake2018

    • Author(s)
      Okata H, Hatta W, Iijima K, Asanuma K, Tsuruya A, Asano N, Koike T, Hamada S, Nakayama T, Masamune A, Shimosegawa T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 244 Issue: 4 Pages: 317-325

    • DOI

      10.1620/tjem.244.317

    • NAID

      130006712062

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

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