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The development of internal dose calculation using Geant4

Research Project

Project/Area Number 17K16440
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

Hiroaki Akasaka  神戸大学, 医学部附属病院, 特命助教 (20707161)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGeant4 / 放射線治療 / ナノ粒子 / 放射線治療計画装置 / ROS / フリーラジカル / がん / シミュレーション / GEANT4 / GEANT4-DNA / 活性酸素 / 放射線治療学
Outline of Final Research Achievements

Geant4-DNA was installed on a PC as a simulation environment setting, and code was written in C + + so that full Monte Carlo simulation and detection of reactive oxygen species accompanying radiation could be performed. Using this simulation environment, we evaluated and examined the difference between the amount of reactive oxygen species generated and the difference between the applied dose and the actual measurement. In the situation of the actual geometry, the density of the nanoparticles was too low, and the effect of the nanoparticles was not recognized in the reactive oxygen species and the applied dose. Dosimeters were used to measure the absolute dose and were compared with the calculations within the simulation. As a result, matching of actual measurement and simulation succeeded. In the future, I would like to move on to calculation of dose distribution using this coefficient.

Academic Significance and Societal Importance of the Research Achievements

本研究では、生物学的なアプローチと物理学的なアプローチ(シミュレーション)を併用することにより、正確に腫瘍が付与される放射線の線量を同定することが可能となる。シミュレーションを用いることにより、様々な状況に対して臨機応変に対応でき、身体のありとあらゆる腫瘍が付与される実際の線量の同定が可能となる。我々は本研究課題において、放射線増感剤と放射線を併用したときの腫瘍組織が付与される実際の線量を実験室レベルで推測することに成功した。生物学的・物理学的な背景も踏まえて処方線量を決定することは、より安全かつ治療効果の高い放射線治療を患者に提供できるようになるので、倫理面から考えてもその意義が大きい。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (22 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Amelioration of Radiation Enteropathy by Dietary Supplementation With Reduced Coenzyme Q102019

    • Author(s)
      Shimizu Yasuyuki、Mukumoto Naritoshi、Idrus Nelly、Akasaka Hiroaki、Inubushi Sachiko、Yoshida Kenji、Miyawaki Daisuke、Ishihara Takeaki、Okamoto Yoshiaki、Yasuda Takahiro、Nakahana Makiko、Sasaki Ryohei
    • Journal Title

      Advances in Radiation Oncology

      Volume: 4 Issue: 2 Pages: 237-245

    • DOI

      10.1016/j.adro.2019.01.006

    • NAID

      120006811120

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gold Nanoparticle-Incorporated Molecularly Imprinted Microgels as Radiation Sensitizers in Pancreatic Cancer2019

    • Author(s)
      Yoshida Aoi、Kitayama Yukiya、Kiguchi Kentaro、Yamada Takuya、Akasaka Hiroaki、Sasaki Ryohei、Takeuchi Toshifumi
    • Journal Title

      ACS Applied Bio Materials

      Volume: 2 Issue: 3 Pages: 1177-1183

    • DOI

      10.1021/acsabm.8b00766

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150?MeV proton beam2019

    • Author(s)
      Abdul Rashid Raizulnasuha、Zainal Abidin Safri、Khairil Anuar Muhammad Afiq、Tominaga Takahiro、Akasaka Hiroaki、Sasaki Ryohei、Kie Katahira、Abdul Razak Khairunisak、Pham Binh. T.T.、Hawkett Brian S.、Carmichael Mary-Ann、Geso Moshi、Rahman Wan Nordiana
    • Journal Title

      OpenNano

      Volume: 4 Pages: 100027-100027

    • DOI

      10.1016/j.onano.2018.100027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique.2018

    • Author(s)
      Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
    • Journal Title

      Journal of Radiation Research

      Volume: 印刷中 Issue: 3 Pages: 316-326

    • DOI

      10.1093/jrr/rry009

    • NAID

      120006477549

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical log data analysis for assessing the accuracy of the CyberKnife fiducial-free lung tumor tracking system2018

    • Author(s)
      Nakayama Masao、Nishimura Hideki、Mayahara Hiroshi、Nakamura Masaki、Uehara Kazuyuki、Tsudou Shinji、Harada Aya、Akasaka Hiroaki、Sasaki Ryohei
    • Journal Title

      Practical Radiation Oncology

      Volume: 8 Issue: 2 Pages: 63-70

    • DOI

      10.1016/j.prro.2017.10.014

    • NAID

      120006873065

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of a Small Animal Irradiation System for Animal Experiments Using EBT3 Model GAFCHROMICTM Film2017

    • Author(s)
      YASUYUKI SHIMIZU, HIROAKI AKASAKA, DAISUKE MIYAWAKI, NARITOSHI MUKUMOTO, MASAO NAKAYAMA, TIANYUAN WANG, SAKI OSUGA, SACHIKO INUBUSHI, RYUICHI YADA, YASUO EJIMA, KENJI YOSHIDA, TAKEAKI ISHIHARA, RYOHEI SASAKI
    • Journal Title

      Kobe J. Med. Sci.

      Volume: 63

    • NAID

      120006380391

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of dual-energy CT to suppression of metal artefact caused by pedicle screw fixation in radiotherapy: a feasibility study using original phantom2017

    • Author(s)
      Wang Tianyuan、Ishihara Takeaki、Kono Atsushi、Yoshida Naoki、Akasaka Hiroaki、Mukumoto Naritoshi、Yada Ryuichi、Ejima Yasuo、Yoshida Kenji、Miyawaki Daisuke、Kakutani Kenichiro、Nishida Kotaro、Negi Noriyuki、Minami Toshiaki、Aoyama Yuuichi、Takahashi Satoru、Sasaki Ryohei
    • Journal Title

      Physics in Medicine & Biology

      Volume: 62 Issue: 15 Pages: 6226-6245

    • DOI

      10.1088/1361-6560/aa7d7f

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 呼吸同期IMRTにおけるInterplay Effectの検討2018

    • Author(s)
      椋本成俊、奥村圭祐、矢田隆一、赤坂浩亮、清水康之、大須賀彩希、中岡藍、西谷隆治、佐々木良平
    • Organizer
      第43回神戸放射線腫瘍懇話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In situステルス性獲得にもとづく長期血中滞留性金ナノ粒子内包分子インプリントナノゲルの創製2018

    • Author(s)
      北山 雄己哉, 山田 託也, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
    • Organizer
      第40回日本バイオマテリアル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 放射線治療のための金ナノ粒子内包分子インプリントポリマーナノゲルの開発2018

    • Author(s)
      北山 雄己哉, 山田 託也, 木口 健太朗, 吉田 碧衣, 赤坂 浩亮, 西村 勇哉, 五十嵐 一紀, 松本 有, 佐々木 良平, 竹内 俊文
    • Organizer
      第40回日本バイオマテリアル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Application of dual-energy CT to suppression of metal artifacts caused by spinal implant in radiotherapy2018

    • Author(s)
      Tianyuan Wang, Takeaki Ishihara, Atsushi Kono, Naoki Yoshida, Noriyuki Negi, Kenichiro Kakutani, Hiroaki Akasaka, Ryuichi Yada, Naritoshi Mukumoto, Daisuke Miyawaki, Kenji Yoshida, Ryohei Sasaki
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 還元型コエンザイムQ10の摂取形状による放射線防護効果の変化2018

    • Author(s)
      清水康之、 椋本成俊、宮脇大輔、犬伏祥子、 赤坂浩亮、矢田隆一、大須賀彩希、佐々木良平
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dosimetric accuracy of dose calculation algorithms for lung heterogeneity phantom2018

    • Author(s)
      Naritoshi Mukumoto, Ryuichi Yada, Keisuke Okumura, Hiroaki Akasaka, Yasuyuki Shimizu, Tianyuan Wang, Saki Osuga, Takaharu Nishitani, Yuichi Aoyama, Ryohei Sasaki
    • Organizer
      第115回日本医学物理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における悪性脳神経膠腫に対するIMRTの治療成績2018

    • Author(s)
      石原武明、妹尾悟史、赤坂浩亮、 椋本成俊、 井上由子、西川遼、 宮脇大輔、 吉田賢史、 佐々木良平、  篠山隆司、 田中一寛
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ガントリー取付式2次元検出器を用いたVMAT検証の可能性・3次元検出器と比較して2018

    • Author(s)
      椋本成俊、奥村圭祐、矢田隆一、赤坂浩亮、西谷隆治、佐々木良平
    • Organizer
      第116回日本医学物理学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肺不均質ファントムにおける線量計算アルゴリズム精度の検討2018

    • Author(s)
      椋本成俊 、矢田隆一、奥村圭祐、江口力斗、赤坂浩亮、清水康之、大須賀彩希、西谷隆治、佐々木良平
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績2017

    • Author(s)
      吉田 賢史, 古川 順也, 宮脇 大輔, 石原 武明, 上薗 玄, 赤坂 浩亮, 西谷 隆治, 藤澤 正人, 佐々木 良平
    • Organizer
      日本放射線腫瘍学会小線源部会第19回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Assessment of adaptive radiation therapy with deformable image registration software2017

    • Author(s)
      Naritoshi Mukumoto, Ryuichi Yada, Yasuyuki Shimizu, Keisuke Okumura, Tianyuan Wang, Saki Osuga, Hiroaki Akasaka, Yuichi Aoyama, Ryohei Sasaki
    • Organizer
      AAPM 59th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of the applied voltage on the ion recombination correction factor using the two-voltage technique in FFF beams2017

    • Author(s)
      Ryuichi Yada, Naoki Hayashi, Naritoshi Mukumoto, Hiroaki Akasaka, Ryohei Sasaki
    • Organizer
      AAPM 59th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The process of the determination of Dosimetric leaf gap and Transmission for VMAT using TrueBeamTM STx2017

    • Author(s)
      Hiroaki Akasaka、Naritoshi Mukumoto、Ryuichi Yada、Tianyuan Wang、Yasuyuki Shimizu、Saki Osuga、Yuichi Aoyama、Ryohei Sasaki
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CT、MRIでの検討に基づく過酸化チタンナノ粒子を用いたTheranostic drugの基礎的検討2017

    • Author(s)
      赤坂浩亮、中山雅央、椋本成俊、荻野千秋、西村勇哉、森田健太、京谷勉輔、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 還元型コエンザイムQ10による腸管の有害事象軽減の検討2017

    • Author(s)
      清水康之、椋本成俊、赤坂浩亮、矢田隆一、王天縁、大須賀彩希、宮脇大輔、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] メタボロミクスにおける放射線消化管機能不全指標の解明2017

    • Author(s)
      大須賀彩希、犬伏祥子、赤坂浩亮、椋本成俊、清水康之、王天縁、宮脇大輔、吉田賢史、石原武明、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 金ナノ粒子との比較による過酸化チタンナノ粒子の放射線増感効果の有用性の検討2017

    • Author(s)
      中山雅央、赤坂浩亮、椋本成俊、荻野千秋、西村勇哉、森田健太、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Novel application of Dual Energy CT for the suppression of metal artifact in Radiotherapy2017

    • Author(s)
      王天縁、石原武明、吉田直基、角谷賢一朗、宮脇大輔、吉田賢史、赤坂浩亮、椋本成俊、矢田隆一、青山裕一、高橋哲、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] DIRソフトウェアを用いたAdaptive radiation therapyの検討2017

    • Author(s)
      椋本成俊、矢田隆一、清水康之、奥村圭祐、王天縁、大須賀彩希、赤坂浩亮、青山裕一、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭頸部領域における固定具を用いたCT画像とMR画像のRegistration精度評価2017

    • Author(s)
      奥村圭祐、椋本成俊、京谷勉輔、西谷隆治、表田真弓、赤坂浩亮、青山裕一、日下亜起子
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 2点電圧法を用いたFFFビームのイオン再結合補正係数の印加電圧の影響2017

    • Author(s)
      矢田隆一、椋本成俊、赤坂浩亮、青山裕一、村木勇太、安達由美子、佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 当院における低・中リスク前立腺癌に対するヨード永久刺入療法の治療成績2017

    • Author(s)
      吉田賢史, 古川順也, 宮脇大輔, 石原武明, 上薗玄, 赤坂浩亮, 西谷隆治, 藤澤正人, 佐々木良平
    • Organizer
      日本放射線腫瘍学会第30回学術大会
    • Related Report
      2017 Research-status Report
  • [Book] Radiotherapy, Chapter 13. A Comparison of Physical vs. Nonphysical Wedge Modalities in Radiotherapy2017

    • Author(s)
      Hiroaki Akasaka, Naritoshi Mukumoto, Masao Nakayama, Tianyuan Wang, Ryuichi Yada, Yasuyuki Shimizu, Saki Osuga, Yuki Wakahara, Ryohei Sasaki
    • Total Pages
      11
    • Publisher
      INTECH
    • ISBN
      9789535131496
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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